Diet and Depression

a study on Depression Weight Gain Obesity Metabolic Syndrome

Eligibility: for people ages 18-80 (full criteria)
Location: at UCSF
Dates: study started June 2024
completion around December 2026
Principal Investigator: by D. Nyasha Chagwedera, MD, PhD (ucsf)Andrew Krystal, MD, MS (ucsf)

D. Nyasha Chagwedera

Andrew Krystal

Description

Summary

This study is a pilot open label crossover trial to assess the feasibility and acceptability of reducing ultra- processed foods (UPF) in a personalized manner from the diets of patients with major depressive disorder who eat a large percentage of UPF.

Official Title

Assessing the Feasibility and Acceptability of the Reduction of Ultra-processed Foods From the Diets of a Subset of Patients With Depression - A Pilot Open Label Crossover Trial.

Details

There is a need for additional treatment or augmentation strategies for people who have depression. Epidemiological and observational studies show that an increased consumption of ultra-processed food (UPF) is associated with an increased risk of developing depression. This study will test the hypothesis that that reducing UPF intake from the diets of patients with major depressive disorder who eat a large percentage of UPF is a feasible and acceptable intervention.

Keywords

Depression, Major Depressive Disorder, Weight Gain, Obesity, Metabolic Syndrome, Ultra-processed Food, Diet, Depressive Disorder, Reduction of Ultra-processed foods

Eligibility

You can join if…

Open to people ages 18-80

18-80 year olds (inclusive), all race/ethnic groups
Willing to not change psychotropic medication or psychotherapy regimen during the study
Willing and able to come to UCSF for in person visits two times
Ability to speak and read English and answer participant surveys

You CAN'T join if...

Psychiatric hospitalization in past 3 months
Active suicidal ideation with intent and plan or scoring a 3 or higher on the Columbia suicide severity rating scale (C-SSRS)
In a current severe mood state when entering the study that would prohibit compliance with study visits or dietary program
Known GI abnormalities or known GI medical problems (diarrhea, chronic intestinal disease, toxic megacolon, ileum) or known swallowing or chewing disorders or issues
Anticipating or planning any major changes in physical activity or sleep during the study
Pregnant or planning to be pregnant during the study
Breastfeeding or planning to breastfeed during the study

Location

University of California, San Francisco accepting new patients
San Francisco California 94107 United States

Lead Scientists at University of California Health

D. Nyasha Chagwedera, MD, PhD (ucsf)
RESIDENT PHYSICIAN, Psychiatry, School of Medicine. Authored (or co-authored) 4 research publications. Research interests: Cardiometabolic Psychiatry · Ultra-processed foods · Diet and Depression
Andrew Krystal, MD, MS (ucsf)
Dr. Krystal is the Ray and Dagmar Dolby Distinguished Professor in the Departments of Psychiatry and Neurology, Vice-Chair for Research in the Department of Psychiatry, Director of the Dolby Family Center for Mood Disorders, Director of the UCSF Interventional Psychiatry Program and Co-Director of the TMS & Neuromodulation Clinic.

Details

Status: accepting new patients
Start Date: June 2024
Completion Date: December 2026 (estimated)
Sponsor: University of California, San Francisco
ID: NCT06252701
Study Type: Interventional
Participants: Expecting 15 study participants
Last Updated: September 2024