Obesity clinical trials at University of California Health

56 in progress, 32 open to eligible people

Showing trials for

  • Mobile Health Intervention to Reduce Sweet Beverage Consumption in Latino Children

    open to eligible people ages 12 months to 59 months

    Sugar-sweetened beverage consumption is a major contributor to childhood obesity, caries, fatty liver disease, and Type 2 diabetes. Latino children are more likely to consume sugar-sweetened beverages (SSBs) and to suffer from all of the…

    at UCSF

  • See if an iPhone Weight Management App Can Help Promote Weight Loss in Adolescents and Young Adults After a Stem Cell Transplant

    open to eligible people ages 13-30

    This early phase I trial studies how well a behavioral weight loss intervention consisting of a smartphone application and coaching works for the promotion of weight loss in adolescents and young adults after a stem cell transplant. This study may…

    at UCLA

  • Obesity in Early Care and Education Settings

    open to eligible people ages 30 months and up

    Childhood obesity is a national epidemic that disproportionately burdens low income and ethnic minority populations. By preschool, nearly one-third of low income children are already overweight or obese, setting the stage for adverse health outcomes …

    at UCLA

  • Behavioral Weight Loss Intervention Utilizing Mobile Health Technology in Hematopoietic Stem Cell Transplant Patients

    open to eligible people ages 13-30

    Pilot study enrolling obese post HSCT (hematopoietic stem cell transplantation) patients at the hematology/oncology clinic at the Mattel Children's Hospital, University of California, Los Angeles. Parameters include percent over the 95th percentile…

    at UCLA

  • Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL

    open to eligible people ages 10-25

    This study is for older children, adolescents, and young adults with B-cell Acute Lymphoblastic Leukemia (B-ALL). Higher amounts of body fat is associated with resistance to chemotherapy in patients with B-ALL. Chemotherapy during the first month…

    at UCSF

  • Childcare Healthy Beverage Access, Food and Beverage Intake, and Obesity

    open to eligible people ages 2-105

    Interventions that promote water consumption in place of sugar-sweetened beverages have shown promise for preventing childhood obesity in schoolchildren. Yet to date, no studies have examined whether applying this approach in childcare centers could …

    at UCSF

  • Diet and Depression

    open to eligible people ages 18-80

    This study is a pilot open label crossover trial to assess the feasibility and acceptability of reducing ultra- processed foods (UPF) in a personalized manner from the diets of patients with major depressive disorder who eat a large percentage of…

    at UCSF

  • Dietary Intervention to Improve Kidney Transplant Outcomes

    open to eligible people ages 18 years and up

    Randomized controlled trial of a curriculum intervention teaching patients to eat a whole-food plant-based dietary pattern versus standard of care in kidney transplant recipients within the first few months of transplant

    at UC Davis

  • Metformin, a Drug Used to Treat Diabetes, vs Placebo

    open to eligible people ages 18 years and up

    Metformin is a drug used to treat patients with diabetes. The aim of this study is to examine the effect of Metformin along with a low-calorie diet on obese and/or overweight adults with an increased waist measurement. In addition, the study also…

    at UCLA

  • Families, Responsibility, Education, Support, and Health for Executive Function

    open to eligible people ages 8-12

    The pilot study will be a one group open-label treatment program and will be used to refine a parent-based behavioral treatment enhanced with executive-function training (PBT-EF) for children with comorbid overweight or obesity and Attention-Deficit …

    at UCSD

  • Family Functioning in Obesity Treatment for Mexican Americans

    open to eligible females ages 18-65

    Mexican American families share similar elevated risks for obesity and obesity-related conditions, such as type 2 diabetes. Because negative family interactions and relationships (e.g., poor communication, high conflict, low emotional closeness) are …

    at UCSD

  • Family Intervention to Prevent Childhood Obesity

    open to eligible people ages 2 years and up

    Consumption of sweetened beverages, media-viewing, and physical activity patterns are often established during early childhood, and family-based obesity interventions show effectiveness in shaping healthy behaviors and weight outcomes for young…

    at UCLA

  • Family, Responsibility, Education, Support, and Health for Families with a Child with Autism

    open to eligible people ages 6-12

    The objective of this proposed study is to collect initial efficacy data on a telehealth parent-based behavioral program for children with autism and overweight or obesity (PBT-A), compared with health education (HE).

    at UCSD

  • Family, Responsibility, Education, Support, and Health for Food Responsiveness

    open to eligible people ages 7-12

    The objective of this proposed study is to compare Regulation of Cues (ROC), Family-Based Treatment (FBT), ROC+ nutrition education and reducing energy intake (ROC+) and a health education comparator (HE) for children with overweight or obesity who…

    at UCSD

  • Family, Responsibility, Education, Support, and Health for Latino Caregivers (FRESH-LC)

    open to eligible people ages 5-12

    The objective of this proposed study is to collect initial efficacy data on a telehealth family-based behavioral program for Latino children with overweight or obesity, which also includes additional caregiver support (PBT-AC), compared with health…

    at UCSD

  • Feasibility and Colorectal Benefits of Pulses Supplementation

    open to eligible people ages 30-80

    Beans are a forgotten staple food that shows promise in improving health. The goal of this study is to look at how bean supplementation affects metabolic and bowel health. In the long-term, the investigators believe this research will lead to a…

    at UC Davis

  • Healing Experiences of Adversity Among Latinos (HEALthy4You)

    open to eligible people ages 5-11

    Healing Experiences of Adversity Among Latinos (HEALthy4You) is a project funded by the California Initiative for the Advancement of Precision Medicine ("Advancing a Precision Population Health Approach to ACEs to Reduce Health Disparities"). The…

    at UCSD

  • Influence of Honey-flavored Yogurt on Low-grade Inflammation and Gut Health in Middle to Older Aged Women.

    “We are inviting women to participate in a research study to test the health benefits of honey-flavored yogurt!”

    open to eligible females ages 45-65

    A randomized, double-blind, crossover dietary intervention trial will test the effects of 4 weeks of daily honey-flavored yogurt intake on markers of inflammation (Th17 cytokines) and oxidative stress (NOX2, UA, RSNO) and associative changes with…

    at UC Davis

  • Metabolic and Bio-behavioral Effects of Following Recommendations in the Dietary Guidelines for Americans

    open to eligible females ages 35-64

    This study, at the Western Human Nutrition Research Center (WHNRC), will focus on whether or not achieving and maintaining a healthy body weight is the most important health promoting recommendation of the Dietary Guidelines for Americans (DGA).The…

    at UC Davis

  • Metabolic Health Improvement Program: Effects of a Workplace Sugary Beverages Sales Ban and Motivational Counseling

    open to eligible people ages 18 years and up

    The purpose of the study is to test the impact of a multilevel workplace intervention (hospital-wide sales ban on sugar-sweetened beverages (SSBs) and individual-level brief counseling) on employee health.

    at UCSF

  • Milk-Tot Study: Impact of Whole Versus Low-fat Milk on Child Health

    open to eligible people ages 23 months to 48 months

    In the U.S. it is recommended that children consume whole cow's milk (3.5% fat) from ages 1 to 2 years to support rapid early growth and brain development, and then at age 2 years transition to low-fat (1%) or non-fat milk to reduce saturated fat…

    at UC Davis

  • Pharmacologic Weight Loss as Adjunct Therapy for Ulcerative Colitis in Obese Patients

    open to eligible people ages 18-80

    Approximately 20-40% of patients with ulcerative colitis (UC) are obese. The investigators have demonstrated that obesity adversely impacts disease course in patients with UC, leading to higher risk of persistently active disease, surgery,…

    at UCSD

  • Pharmacotherapy in Conjunction With Lifestyle Counseling for Management of Weight Regain After Bariatric Surgery

    open to eligible people ages 18-70

    This is a randomized controlled trial employing a Sequential Multiple Assignment Randomized Trial (SMART) design to test whether pharmacotherapy, in conjunction with lifestyle counseling, can reverse weight regain after bariatric surgery.

    at UC Irvine

  • Probiotic Intervention Study

    open to eligible people ages 18-50

    The current standard of care for obesity is the optimal management of comorbid conditions such as diabetes and hyperlipidemia, and counseling on diet, weight loss, or increased physical activity programs. However, lifestyle, diet, and behavioral…

    at UCLA

  • Semaglutide Treatment in the Real-world for Fibrosis Due to NAFLD in Obesity and T2DM

    open to eligible people ages 40-79

    Conduct a community intervention study that will 1) validate a screening approach to identify patients at risk for advanced NAFLD in the obese or T2DM population, and 2) test whether semaglutide treatment is effective for the management of…

    at UCSD

  • Telenutrition for Individuals With SCI

    open to eligible people ages 20 years and up

    This study will provide nutrition counseling via FaceTime on an iPad to persons with traumatic spinal cord injury (SCI) who are overweight or obese and are at least one-year post-injury. Nutrition counseling may help participants to develop eating…

    at UCSF

  • Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)

    open to eligible people ages 45 years and up

    The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function. The trial will enroll adults with body mass index 27 kg/m^2 or…

    at UCLA

  • Continuous Glucose Monitors in Children and Adolescents With Obesity

    open to eligible people ages 10-21

    To study if continuous glucose monitors are feasible for use in children and adolescents with obesity.

    at UCLA

  • Brown Adipose Tissue Activity in Response to Semaglutide Administered to Obese Subjects.

    open to eligible people ages 18 years and up

    Glucagon like peptide (GLP-1) agonists, such as liraglutide, exenatide, and semaglutide, have been increasingly used as a medication to address the current twin epidemics of diabetes and obesity. Their activities include increasing insulin…

    at UCLA

  • Ethnic Influences on Stress, Energy Balance and Obesity in Adolescents

    open to eligible females ages 13-17

    The study will examine the mechanisms linking race, stress and biobehavioral factors to energy balance and obesity in both natural and controlled environments in African-American and Caucasian adolescent females. A Hispanic/Latina cohort has…

    at UC Irvine

  • Inflammation, Diabetes, Ethnicity and Obesity Cohort

    open to eligible people ages 18-75

    Obesity affects over one third of US adults (>72 million, with BMI ≥30 kg/m2), and the proportion of US adults with BMI ≥40 kg/m2 has doubled in the last 20 years. Obesity is associated with increased mortality through its linkage to comorbidities…

    at UCSF

  • Metabolic Responses to Bariatric Surgery

    “Using tissue samples to better understand the metabolism and genetics of obesity”

    open to eligible people ages 18-55

    Research the genetic and biomechanical markers of human adipose tissue on patients with morbid obesity. Additional tissue/fluid collection is also gathered during the time of surgery.

    at UC Davis

  • Fenretinide Administered in Subjects With Obesity

    Sorry, currently not accepting new patients, but might later

    Many metabolic complications of obesity are a consequence of abnormal responses of the liver, muscle, and fat to insulin actions. Fenretinide may improve the effects of insulin, preventing metabolic complications.

    at UCSD

  • Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk

    Sorry, in progress, not accepting new patients

    The main purpose of this study is to determine safety and efficacy of orforglipron compared with insulin glargine in participants with type 2 diabetes and obesity or overweight at increased cardiovascular risk. The study will last approximately 2…

    at UCLA

  • Olive Oil Polyphenols and Cardiovascular Health Biomarkers

    Sorry, in progress, not accepting new patients

    The purpose of this research is to investigate whether consuming two different kinds of olive oil will change risk factors related to cardiovascular disease, including levels of good and bad cholesterol, levels of inflammation, and levels of gene…

    at UC Davis

  • Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity

    Sorry, in progress, not accepting new patients

    This study will investigate the effect of tirzepatide on the reduction of morbidity and mortality in adults living with obesity and provide additional evidence for the potential clinical benefits of tirzepatide in this population.

    at UC Irvine UCLA

  • ADRB3 Signaling Pathway in Human Adipose Tissue

    Sorry, in progress, not accepting new patients

    This study will examine the gene expression of the adrenergic Beta-3 receptor (ADRB3) regulation in human subcutaneous adipose tissue before and after treatment with mirabegron, an ADRB3 agonist. Gene expression will be compared across two groups,…

    at UCSD

  • Breast Cancer WEight Loss Study (BWEL Study)

    Sorry, in progress, not accepting new patients

    This randomized phase III trial studies whether weight loss in overweight and obese women may prevent breast cancer from coming back (recurrence). Previous studies have found that women who are overweight or obese when their breast cancer is found…

    at UC Davis UCSD UCSF

  • Determine How Consumption of Dairy Fat as Cheese Influences Inflammation-Phase 2

    Sorry, in progress, not accepting new patients

    Phase 2 of this study involves determining how consumption of cheese compared with a non-dairy cheese substitute influences inflammation over a six hour period.

    at UC Davis

  • Determine How Consumption of Dairy Fat Fractions Rich in Phospholipids and Proteins Influence Inflammation in the Fed State-Phase 1

    Sorry, in progress, not accepting new patients

    Phase 1 of this study involves determining how consumption of dairy fat fractions rich in milk fat globule membrane influences postprandial inflammation in participants with metabolic syndrome or obesity during a high dietary fat challenge in a…

    at UC Davis

  • Dissemination and Implementation of the Bright Bodies Intervention for Childhood Obesity

    Sorry, in progress, not accepting new patients

    This study will evaluate the effectiveness of the Bright Bodies intervention in improving body mass index (BMI) among 7-13 year-old children with obesity simultaneously with the impact of the implementation strategy on adoption, reach, fidelity,…

    at UCSF

  • Time-restricted Eating on Catecholamine-sensitivity of Adipose Tissue in Obese Adults

    Sorry, in progress, not accepting new patients

    In a randomized controlled trial, the investigators intend to measure the health impact of time-restricted eating (TRE) in obese patients (body mass index (BMI) ≥ 30 kg/m2), who habitually eat for more than 14 hours every day. Patients will be…

    at UCSD

  • Negative Affect in Individuals With Binge Eating Episodes

    Sorry, in progress, not accepting new patients

    Binge-eating is characterized by recurrent episodes of eating large amounts of - typically high calorie - foods, eating much more rapidly than normal and until feeling uncomfortably full, as well as feeling disgusted with oneself, depressed, or…

    at UCSD

  • Futuros Fuertes 2.0

    Sorry, not yet accepting patients

    The goal of this study is to evaluate the impact of a primary care based intervention to promote optimal feeding, screen time and sleep practices among low-income Latino infants and toddlers. Infants and caregivers will receive brief health…

    at UCSF

  • Goals for Reaching Optimal Wellness: GROWell

    “We're looking for healthy pregnant people to participate in a mobile health program”

    Sorry, in progress, not accepting new patients

    Despite the negative consequences to maternal-child health from women gaining too much weight during pregnancy, up to 62% of overweight and obese women gain more pregnancy weight than is recommended. This project will establish the efficacy of Goals …

    at UC Davis

  • Mechanistic and Clinical Outcomes of a Surgical Innovation Aimed At Minimizing GERD Associated with VSG (INNOVATE-VSG)

    Sorry, not yet accepting patients

    This is a two-site randomized clinical trial aiming to test whether a modified investigational bariatric surgical procedure can improve gastroesophageal reflux disease (GERD) after sleeve gastrectomy.

    at UC Irvine UCSD

  • Methylglyoxal (MGO) Lowering Cocktail to Reduce Appetite in Obese Individuals

    Sorry, not yet accepting patients

    Mechanisms that drive addiction to sugar rich foods are a major driving factor in the pathogenesis of obesity, which has become one of the most significant health care burdens. The molecular underpinnings of these hedonic mechanisms that drive…

    at UCSF

  • Extension Study of Setmelanotide

    Sorry, accepting new patients by invitation only

    This is an open-label extension study designed to evaluate the long-term safety and tolerability of continued setmelanotide treatment in male and female patients ≥2 years of age who have completed or transitioned from a previous study with…

    at UCSD

  • Semaglutide to Reduce Atrial Fibrillation Burden

    Sorry, currently not accepting new patients, but might later

    Atrial fibrillation (AF) is the most common arrhythmia worldwide. AF is associated with obesity and the co-morbidities of obesity, including hypertension and obstructive sleep apnea (OSA) which increase left atrial (LA) size and decrease LA…

    at UCSF

  • Solutions for Hunger and Regulating Eating

    Sorry, in progress, not accepting new patients

    The objective of this proposed study is to collect efficacy data on ROC+ compared to an active comparator (AC) and to Behavioral Weight Loss (BWL) for participants who are high in Food Responsiveness.

    at UCSD

  • Teaching Kitchen Multisite Trial

    Sorry, accepting new patients by invitation only

    This TK-MT is an interactive year-long program that teaches culinary skills, nutrition education, mindfulness, and stress reduction, promotes movement, and optimizes behavior change through health coaching strategies. The purpose of this study is to …

    at UC Irvine UCLA

  • Test Whether Time-restricted Eating Coupled with a Healthy Diet is Beneficial in Liver Cancer Patients

    Sorry, not yet accepting patients

    This is a feasibility study that will collect data to assess the potential effect of a nutritional intervention designed to improve liver metabolism. This prospective single-site trial will enroll adult patients undergoing liver-directed therapies…

    at UCSD

  • Cognitive Impairment, Obesity, and the Effects of Bariatric Surgery

    Sorry, accepting new patients by invitation only

    Study is designed to screen psychological cognitive baseline and retention/improvement after weight loss surgery.

    at UC Davis

  • El Sendero: Pathways to Health Study

    Sorry, accepting new patients by invitation only

    This project will continue to follow two birth cohorts of mother-infant Latino dyads through a series of new assessments at age 6y, with an emphasis on examining the the role early nutritional exposures, exposures to environmental toxins, and social …

    at UCSD

  • Natural Sugars in Breast Milk on Healthy Infant Growth and Development

    Sorry, in progress, not accepting new patients

    This study will investigate the effects of breastfeeding and breastmilk composition on infant gut microbiome development as well as obesity and cognitive outcomes. Breast milk contains certain natural sugars that can promote the growth of 'good'…

    at UCSD

  • Underlying Mechanisms of Obesity-induced Obstructive Sleep Apnea

    Sorry, accepting new patients by invitation only

    Obesity is a common risk factor for the development of obstructive sleep apnea. However, not all subjects with obesity develop obstructive sleep apnea. This study will attempt to determine the mechanistic drivers between obesity and obstructive…

    at UCSD

Our lead scientists for Obesity research studies include .

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