This study is not yet accepting patients

The Synergistic Effects of Menopause and HIV on Cardiovascular Disease Risk in Women

a study on HIV/AIDS Menopause Cardiovascular (CV) Risk Carotid Arteriosclerosis Body Composition Cardiovascular Disease Peripheral Artery Disease

Summary

Eligibility
for females ages 18 years and up (full criteria)
Location
at UCSF
Dates
study started
study ends around
Principal Investigator
by Rebecca Abelman, MD (ucsf)
Headshot of Rebecca Abelman
Rebecca Abelman

Description

Summary

Menopause is associated with the acceleration of many comorbidities, including cardiovascular disease. Whether HIV and menopause together increase cardiovascular disease risk is a key knowledge gap. The goal of this observational study is to address this knowledge gap by looking at the role of menopause on cardiovascular disease risk factors such as insulin resistance, hypertension, hyperlipidemia, and carotid atherosclerosis using previously collected data. The investigators will look at underlying causes for cardiovascular diseases worsening in menopausal women with HIV by looking at the role of increased inflammation in the body and whether this is altered by weight. The investigators achieve this by enrolling participants who are willing to undergo a whole body MRI.

Keywords

HIV, Menopause, Cardiovascular (CV) Risk, Carotid Arteriosclerosis, Body Composition, Carotid Artery Diseases, Whole body MRI

Eligibility

You can join if…

Open to females ages 18 years and up

  • 90 non-pregnant women with HIV (approximately 30 in each menopausal phase) from the San Francisco MWCCS site.

You CAN'T join if...

  • Women who are not virally suppressed (HIV RNA >200 copies/mL)
  • Women who are not on antiretroviral therapy
  • Women who have a history of hysterectomy or oophorectomy
  • Women who are receiving treatment for active cancer or tuberculosis

Location

  • University of California, San Francisco
    San Francisco California 94110 United States

Lead Scientist at University of California Health

  • Rebecca Abelman, MD (ucsf)
    Dr. Abelman is an Assistant Professor at the University of California San Francisco in the Division of Infectious Diseases at the San Francisco Veterans Affairs Health Care System. Her research is focused on sex differences in aging-related comorbidities in people living with HIV and the role of menopause on clinical outcomes in women with HIV.

Details

Status
not yet accepting patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT07284082
Study Type
Observational
Participants
Expecting 90 study participants
Last Updated