A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer

Open to females ages 18 years and up

Cohort 1:

• Have histologically confirmed Stage I to III Estrogen Receptor positive (ER+), human epidermal growth factor receptor 2 negative (HER2-) invasive breast carcinoma with Ki-67 at least 10%
• Be willing and able to provide pre- and on-treatment tumor samples.
• Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
• Be able to swallow capsules or tablets.
• Be premenopausal women.
• If of childbearing potential must use 1 highly effective method of non-hormonal contraception while receiving study treatment and for the duration specified in protocol.
• Have adequate organ function.

Cohort 2:

• Have a diagnosis of ER+, HER2- early-stage, resected, invasive breast cancer without evidence of distant metastasis
• Have undergone definitive loco-regional therapy.
• Have received at least 4.5 years of any adjuvant endocrine therapy (ET), or at least 2 years of adjuvant ET with no additional ovarian suppression planned.
• Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
• Be able to swallow capsules or tablets.
• Be premenopausal women
• If of childbearing potential must use 1 highly effective method of non-hormonal contraception while receiving study treatment and for the duration specified in protocol.
• Have adequate organ function.

Cohort 1:

• Have bilateral invasive metastatic, occult primary, or inflammatory breast cancer.
• Have had prior bilateral oophorectomy or ovarian ablation.
• Have a serious medical condition
• Had major surgery within 28 days prior to randomization.
• Have a history of other cancer (except non melanoma skin cancer, Stage I uterine cancer, or carcinoma in situ of the cervix or other in situ cancer), unless in complete remission with no therapy for a minimum of 1 year.
• Plan to receive concurrent neoadjuvant therapy with any other non-protocol anticancer therapy.
• Have had any prior therapy for an invasive or non-invasive breast cancer.
• Have had prior radiotherapy to the ipsilateral chest wall for any malignancy.
• Have received prior anti-estrogen therapy, including for osteoporosis or prevention of breast cancer.
• Have had prior treatment with any Gonadotropin-releasing hormone (GnRH) agonist within 12 months prior to randomization.
• Receiving current exogenous reproductive hormone therapy

Cohort 2:

• Have ovarian cyst(s) greater than (>) 1 centimeter (cm) at screening.
• Have metastatic occult primary, or inflammatory breast cancer.
• Have had prior bilateral oophorectomy or ovarian ablation.
• Have a serious medical condition
• Had major surgery within 28 days prior to randomization.
• Have a history of other cancer (except non melanoma skin cancer or carcinoma in situ of the cervix or other in situ cancer), unless in complete remission with no therapy for a minimum of 1 year.
• Completed or discontinued prior adjuvant ET >6 months prior to screening.
• Have received prior therapy with any selective estrogen receptor degrader (SERD).
• Receiving current exogenous reproductive hormone therapy.