This study is not yet accepting patients

Stimulant and Polysubstance Use, Inflammation, and Sex Effects on Myocardial Disease in HIV

a study on HIV/AIDS Immunodeficiency

Summary

Eligibility
for people ages 30 years and up (full criteria)
Location
at UCSF
Dates
study started
study ends around
Principal Investigator
by Phyllis Tien, MD (ucsf)Elise Riley, PhD (ucsf)
Headshot of Phyllis Tien
Phyllis Tien
Headshot of Elise Riley
Elise Riley

Description

Summary

This observational research study is studying how substance use impacts scarring and inflammation of the heart. This study involves one study visit for a cardiac MRI.

Official Title

Stimulant and Polysubstance Use, Inflammation, and Sex Effects on Myocardial Disease in HIV (SPISE)

Keywords

HIV (Human Immunodeficiency Virus), HIV, cardiac MRI, stimulant use, Acquired Immunodeficiency Syndrome, Current Stimulant Use, Past Stimulant Use

Eligibility

You can join if…

Open to people ages 30 years and up

  • Participants with and without HIV enrolled in the MACS/WIHS Combined Cohort Study (MWCCS) Atlanta, Baltimore, Bronx, and San Francisco study sites

You CAN'T join if...

  • Standard contraindications to MRI
  • claustrophobia,
  • metal implants,
  • large body size (weight >350 lbs or abdominal sagittal diameter >70 cm),
  • pregnancy)
  • Gadolinium risk
  • severe or uncontrolled asthma,
  • visit day eGFR<45 ml/min/1.73 m2;
  • poor venous access
  • pregnancy or lactation

Locations

  • University of California, San Francisco
    San Francisco California 94115 United States
  • Emory University, School of Medicine
    Atlanta Georgia 30322 United States
  • Johns Hopkins University
    Baltimore Maryland 21218 United States
  • Albert Einstein College of Medicine
    The Bronx New York 10462 United States

Lead Scientists at University of California Health

  • Phyllis Tien, MD (ucsf)
    Dr. Tien is Professor of Medicine at the University of California, San Francisco, and Chief of the Infectious Diseases Division at the San Francisco VA Health Care System. Her research program investigates how chronic viral infections—particularly HIV and HCV—and their associated metabolic and immune perturbations drive long-term organ injury in adults, with a primary focus on women.
  • Elise Riley, PhD (ucsf)
    Trained as an infectious disease epidemiologist, Dr. Riley is interested in how clinical, biological, and behavioral factors converge to influence health. Her clinical and community-based research focuses on comorbidities and competing risks in very low-income populations, with an emphasis on housing instability and associated conditions.

Details

Status
not yet accepting patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT07461350
Study Type
Observational [Patient Registry]
Participants
Expecting 400 study participants
Last Updated