A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk

Open to people ages 45-80

• Have an Lp(a) ≥175 nmol/L
• Have established cardiovascular (CV) disease or are at risk for a first CV event
• Have angiographic evidence of coronary artery disease on screening CCTA
• If taking lipid-lowering medications, inclusive of statins or prescription strength niacin and PCSK9 inhibitors, these should be stable for 8 weeks

• Have had a major CV event less than 60 days before measurement of the Lp(a) level used for eligibility or uncontrolled high blood pressure at screening
• Have moderate to severe renal dysfunction
• Have severe heart failure
• Have a history of coronary artery bypass graft surgery (CABG)
• Have a planned coronary angiography, percutaneous coronary intervention (PCI), coronary artery bypass graft, or valvular intervention
• Have had a procedure to remove lipoproteins from the blood or received therapy specifically targeting Lp(a)
• Are unable to safely undergo CCTA due to medication intolerance, contrast allergies, or anatomical/technical factors