This study is in progress, not accepting new patients

Open-Label Extension Study of BBP-418 (Ribitol) for LGMD2I/R9

a study on Limb-Girdle Muscular Dystrophy

Summary

Location
at UC Irvine
Dates
study started
study ends around

Description

Summary

This is an open-label extension (rollover) study designed to evaluate the long-term safety and efficacy of BBP-418 (ribitol) in participants with limb-girdle muscular dystrophy type 2I/R9 (LGMD2I/R9) who have previously participated in Study MLB-01-005 (Fortify).

Participants will receive BBP-418 administered orally at protocol-defined doses and schedules. The study will assess long-term safety through monitoring of adverse events, clinical laboratory evaluations, and other safety assessments. Efficacy will be evaluated using functional measures and other clinical endpoints relevant to LGMD2I/R9.

Participants will be followed for up to 36 months, with a final safety follow-up assessment conducted approximately 30 days after the last dose of study drug.

Official Title

An Open-Label Extension Study to Evaluate the Long-Term Safety and Efficacy of BBP-418 (Ribitol) in Participants With Limb-Girdle Muscular Dystrophy 2I/R9 (LGMD2I/R9)

Keywords

Limb-Girdle Muscular Dystrophy Type 2I (LGMD2I), LGMD2I/R9, Muscular Dystrophy, Limb-Girdle, Type 2I, Ribitol, BBP-418 (ribitol)

Eligibility

You can join if…

  • Completed Study MLB-01-005 on study drug through the final clinic visit (Month 36 or another qualifying end-of-study visit as determined by the Sponsor).
  • The participant (or parent/guardian) who signs the ICF understands the study procedures and agrees to participate in the study by giving informed consent (or assent, if <18 years of age).
  • Is willing and able to complete all study procedures according to the Schedule of Assessments.
  • A WOCBP or a nonsterile male participant must be willing to use an acceptable method of contraception from the time of consent through 30 days after the last dose of study drug in this study.

You CAN'T join if...

  • Has developed clinically significant concomitant disease that would, in the Investigator's opinion, be likely to unfavorably impact study participation, including:
    • Any significant concomitant medical condition, including psychiatric, cardiac, renal, pulmonary, hepatic, or endocrine disease other than that associated with LGMD2I/R9
    • Any other significant laboratory, vital sign, ECG abnormality, clinical history, or finding
  • Is pregnant (based on the Baseline / Day 1 pregnancy test result) and/or breastfeeding or planning to conceive children within the projected duration of the study through 30 days after the last dose of study drug in this study.
  • Has active suicidal ideation, defined as having a suicide ideation score of 4 (Active Suicidal Ideation with Some Intent to Act, without Specific Plan) or 5 (Active Suicidal Ideation with Specific Plan and Intent) on the C-SSRS at Baseline / Day 1.

Locations

  • University of California Irvine Medical Center
    Orange California 92868 United States
  • University of Colorado Hospital (UCH) - Anschutz Medical Campus
    Aurora Colorado 80045 United States

Details

Status
in progress, not accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
ML Bio Solutions, Inc.
ID
NCT07678775
Phase
Phase 3 Limb-Girdle Muscular Dystrophy Research Study
Study Type
Interventional
Participants
Expecting 107 study participants
Last Updated