Diabetes clinical trials at University of California Health
111 in progress, 52 open to eligible people
if the Study Drug Diamyd Can Preserve Insulin Production and Improve Glycemic Control in Patients Newly Diagnosed With Type 1 Diabetes
open to eligible people ages 12-28
The objective of DIAGNODE-3 is to evaluate the efficacy and safety of three intranodal injections of 4 μg of Diamyd compared to placebo, along with oral Vitamin D supplementation, to preserve endogenous beta cell function and influence glycemic…
at UCSD
Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events
open to eligible people ages 55 years and up
TRANSFORM is a prospective, randomized, open blinded endpoint (PROBE), event-driven, pragmatic trial in patients who are at increased risk for atherosclerotic cardiovascular (CV) disease but with no known symptomatic CV disease. The trial tests the…
at UCLA
VX-880 in Participants With Type 1 Diabetes
open to eligible people ages 18-65
This study will evaluate the safety, tolerability and efficacy of VX-880 infusion in participants with Type 1 diabetes (T1D) and impaired awareness of hypoglycemia (IAH) and severe hypoglycemia.
at UCSF
REACT in Subjects With Type 2 Diabetes Mellitus and Chronic Kidney Disease
open to eligible people ages 30-80
The purpose of this study is to assess the safety and efficacy (including durability) of up to 2 REACT injections given 3 months (+30 days) apart and delivered percutaneously into biopsied and non-biopsied contralateral kidneys in participants with…
at UC Davis
Acetazolamide in Persons with Type 1 Diabetes
open to eligible people ages 18 years and up
This is a dose finding trial where participants will receive escalating doses of acetazolamide, each for a 2-week dosing period followed by a 2-week washout period. The three doses examined will be open-label 62.5mg twice daily, 125mg twice daily,…
at UCSD
Achieving Chronic Care equiTy by leVeraging the Telehealth Ecosystem
open to eligible people ages 18 years and up
This study examines the impact of a multi-level intervention aiming to improve telehealth access for low-income patients managing chronic health conditions, such as hypertension and diabetes. The multi-level intervention includes clinic-level…
at UCSF
Bacteriophage Therapy in Patients With Diabetic Foot Osteomyelitis
open to eligible people ages 18-85
This is a phase IIa randomized trial designed to evaluate bacteriophage therapy in patients with diabetic foot osteomyelitis.
at UCLA
CGM in Kidney Transplant Recipients
“Volunteer for research and contribute to discoveries that may improve health care for you, your family, and your community!”
open to eligible people ages 18 years and up
The investigators want to study the impact CGM (continuous glucose monitoring) has on patients glycemic control as determined by time in range (TIR 70-180 mg/dL) in the Diabetic Kidney Transplant population.
at UC Davis
Combination Adjunctive Therapy to Address Multiple Metabolic Imbalances in Type 1 Diabetes
open to eligible people ages 18-70
This is a single site, double-blind, placebo-controlled, crossover trial to quantify the effects of combination adjunctive therapy on glycemic control, ketogenesis during insulinopenia, insulin resistance, and diabetes burden and quality of life.
at UCSD
Conscious Pregnancy: Supporting Maternal Cardiometabolic Health With Mindfulness
open to eligible females ages 18 years and up
A pilot randomized control trial (RCT) to examine the efficacy of a culturally tailored mindfulness intervention upon fasting cardiometabolic factors (including markers of glycemic control) and inflammatory gene expression in n=60 (n=30…
at UC Irvine
Continuous Glucose Monitoring in Dialysis Patients to Overcome Dysglycemia Trial
open to eligible people ages 18-99
This randomized controlled trial will investigate whether use of continuous glucose monitoring (CGM) vs. usual care with self-monitored blood glucose 1) enhances glycemic control, 2) reduces hypoglycemia risk, and 3) improves quality of life,…
at UC Irvine
Continuous Glucose Monitoring System Feasibility in Youth With T2D
open to eligible people ages 8-20
The primary scientific question of this proposal is to investigate whether youth with T2D will wear and interact with a continuous glucose monitor (CGM) system and whether this will influence behavior and management decisions. There will be 30…
at UCSF
Dementia and Diabetes Prevention Program
open to eligible people ages 60 years and up
This is a multicenter, randomized 2-arm clinical trial of two lifestyle interventions varying in intensity and format, in 400 older African American and non-Hispanic whites at increased risk of cognitive decline and dementia in the East San…
at UC Davis
DETERMINE: Detemir vs NPH
open to eligible people ages 18 years and up
The purpose of the study is to compare rates of neonatal hypoglycemia with maternal NPH vs determir use.
at UCLA
Developing and Testing a Self-Compassion Tool Kit to Improve the Care of Individuals With Type 2 Diabetes
open to eligible people ages 18 years and up
There is a high prevalence of anxiety and depression in patients with Type 2 Diabetes (T2D). While past studies demonstrate the potential therapeutic effect of mindfulness-based interventions in patients with T2D, little is understood about the mode …
at UCSD
Device Use Reimagined Through Education And Mentorship
open to eligible people ages 13-17
Diabetes technology, such as insulin pumps and continuous glucose monitoring devices, can help improve glucose control for people with type 1 diabetes (T1D), which keeps them at lower risk for diabetes complications, but many Latinx adolescents, who …
at UC Davis UCSF
Dietary Intervention to Improve Kidney Transplant Outcomes
open to eligible people ages 18 years and up
Randomized controlled trial of a curriculum intervention teaching patients to eat a whole-food plant-based dietary pattern versus standard of care in kidney transplant recipients within the first few months of transplant
at UC Davis
Dosimetry of Tc-99m-Tilmanocept
open to eligible people ages 18 years and up
This proposal will use kidney SPECT/CT of Tc-99m-tilmanocept to evaluate the mesangial changes seen in diabetics across the spectrum of kidney disease as well as persons with hypertensive kidney disease, the next most common cause of kidney disease…
at UCSD
Metformin, a Drug Used to Treat Diabetes, vs Placebo
open to eligible people ages 18 years and up
Metformin is a drug used to treat patients with diabetes. The aim of this study is to examine the effect of Metformin along with a low-calorie diet on obese and/or overweight adults with an increased waist measurement. In addition, the study also…
at UCLA
Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)
open to eligible people ages 18 years and up
The purpose of this study is to investigate the efficacy and safety of retatrutide compared with placebo in participants with Type 2 Diabetes and renal impairment, with inadequate glycemic control on basal insulin alone or a combination of basal…
at UCLA
Tirzepatide on Progression of Coronary Atherosclerosis Using MDCT
open to eligible people ages 40-80
A multi-center, randomized, double-blind, placebo-controlled, parallel-group phase IV Study evaluating the effects of tirzepatide on atherosclerotic plaque progression assessed by coronary computed tomography angiography (CCTA) in participants with…
at UCLA
EPPIC-Net: Novaremed Painful Diabetic Peripheral Neuropathy ISA
open to eligible people ages 18 years and up
The purpose of this study is to investigate the safety and efficacy of the current hard gelatin capsule formulation of NRD135S.E1 80 mg once daily in the treatment of PDPN when administered for 13 weeks.
at UCSD
EPPIC-Net: Platform Protocol to Assess Treatments for Painful Diabetic Peripheral Neuropathy
open to eligible people ages 18 years and up
This is a Platform Protocol to perform Phase II clinical trials in The Early Phase Pain Investigation Clinical Network (EPPIC-Net), under The Helping to End Addiction Long-termSM Initiative, or NIH HEAL InitiativeSM, related to the treatment of…
at UCSD
Tradipitant vs. Placebo in Idiopathic and Diabetic Gastroparesis
open to eligible people ages 18-70
To investigate the safety and efficacy of tradipitant versus placebo in relieving nausea and other symptoms of gastroparesis.
at UCSD
Bolus for Meals in a Closed-loop System
open to eligible people ages 13-19
This study aims to evaluate whether the use of an extended bolus will improve glucose control with high-fat high protein meals using a closed-loop system. The new knowledge gained from this study may provide a method to allow for the proper…
at UCSF
Fenofibrate for Prevention of DR Worsening
open to eligible people ages 18-80
This randomized trial will evaluate the effect of fenofibrate compared with placebo for prevention of diabetic retinopathy (DR) worsening through 6 years of follow-up in eyes with mild to moderately severe non-proliferative DR (NPDR) and no CI-DME…
at UC Davis UCSF
FrexalimAB in Preservation of Endogenous insULIN Secretion Compared to Placebo in adUlts and Adolescents on Top of inSulin Therapy (FABULINUS)
open to eligible people ages 12-35
This is a randomized, parallel group, double-blind Phase 2 study with a 52-week blinded extension evaluating the safety and efficacy of 3 dose levels of frexalimab in comparison with placebo in participants with newly diagnosed T1D on insulin…
at UCSF
Improving Islet Transplantation Outcomes With Gastrin for Type I Diabetes
open to eligible people ages 18-68
This clinical study will evaluate the safety and effectiveness of Gastrin treatment with islet transplantation to help patients with difficult to control type 1 diabetes make insulin again and improve blood sugar control. This study involves two…
at UCLA
Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes
open to eligible people ages 18 years and up
This research will help us to learn if the medicine called metformin reduces the risk of death, heart attacks, and/or strokes in Veterans who have pre-diabetes and heart or blood vessel problems.
at UCLA UCSD
Janus Kinase (JAK) Inhibitors to Preserve C-Peptide Production in New Onset Type 1 Diabetes (T1D)
open to eligible people ages 12-35
A multi-center, placebo-controlled, double blind, 1:1:1 randomized control clinical trial testing two different JAK Inhibitors abrocitnib, ritlecitinib, and placebo in subjects with recent onset Stage 3 Type 1 Diabetes within 100 days of diagnosis.
at UCSF
More Fresh Fruit and Vegetable Prescription Program for Families with Type 2 Diabetes Mellitus
open to eligible people ages up to 18 years
Rady Children's Hospital San Diego (RCHSD), UCSD Division of Child and Community Health and the Center for Community Health, and Northgate Gonzalez (NG) Markets will collaborate to create a Produce Prescription Program (Fruit and Vegetable…
at UCSD
Precision Dosing of Metformin in Youth With T2D
open to eligible people ages 10-21
The purpose of this study to compare the typically prescribed dose of metformin (1000mg twice a day) with a higher dose of metformin (1350mg twice a day).
at UCSF
Cannabis Derivatives in Neuropathic Pain
open to eligible people ages 21 years and up
Chronic neuropathic pain (CNP) is disabling. Research on frontline treatments for CNP, shows inconsistent outcomes and dissatisfaction among Veterans. Veterans and clinicians have shown significant interest in cannabis derivatives (THC, CBD) for…
at UCSD
Quasi-Randomized Evaluation of the UCLA Next Day Clinic (NDC)
open to eligible people ages 18 years and up
The Next Day Clinic (NDC) is a quality improvement initiative that will be launched and operated by UCLA Health starting July 22, 2024. Its goals are to improve patient care and safety and to maximize cost effectiveness. The way it does this is by…
at UCLA
Supplemental Synchronous and Asynchronous Telehealth to Improve Glycemic Control for Pediatric Patients With Type 1 Diabetes
open to eligible people ages 5-18
This study will test the hypothesis that supplemental synchronous video visits and supplemental asynchronous remote monitoring can each significantly improve glycemic control for pediatric patients with uncontrolled type 1 diabetes over a 6 month…
at UC Davis
Rituximab-pvvr and Abatacept Vs Rituximab-pvvr Alone in New Onset Type 1 Diabetes
open to eligible people ages 8-45
The study is a two-arm, multicenter, double-blinded clinical trial testing sequential therapy with rituximab-pvvr followed by abatacept versus rituximab-pvvr alone in new onset T1D. The primary objective is to test whether the C-peptide response to…
at UCSF
Endoscopic Intestinal Re-Cellularization Therapy in Individuals With Type II Diabetes
open to eligible people ages 22-70
This study is designed to evaluate the safety and effectiveness of endoscopic intestinal re-cellularization therapy in individuals with type 2 diabetes (T2D) inadequately controlled on non-insulin glucose-lowering medications.
at UCLA
MiniMed™ 780G System with DS5 CGM in Children
open to eligible people ages 2-6
The purpose of this study is to evaluate the safety of the MiniMed 780G insulin pump used in combination with the DS5 CGM in type 1 pediatric subjects (2-6 years of age) in a home setting.
at UCSF
Semaglutide Treatment in the Real-world for Fibrosis Due to NAFLD in Obesity and T2DM
open to eligible people ages 40-79
Conduct a community intervention study that will 1) validate a screening approach to identify patients at risk for advanced NAFLD in the obese or T2DM population, and 2) test whether semaglutide treatment is effective for the management of…
at UCSD
Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD
open to eligible people ages 21-85
Skeletal muscle metabolic health is critical for mobility and an underrecognized target of metabolic acidosis in chronic kidney disease. Impaired muscle mitochondrial metabolism underlies poor physical endurance increasing the risk of mobility…
at UC Davis
SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN
open to eligible people ages 18 years and up
The purpose of this single-arm interventional study is to evaluate the long-term safety, efficacy, and durability of the Symplicity Spyral system in subjects treated with renal denervation. Additionally, long-term follow-up data will also be…
at UCSF
Starting Technology in At Risk Type 1 Diabetes Study
open to eligible people ages 18 years and up
Diabetes technology has revolutionized T1D management, disparities in technology access are evident among racial-ethnic minorities, patients with lower socioeconomic status and those with poorly controlled T1D (A1c>8.5%). In order to examine whether …
at UCLA
Time-Restricted Eating for Type II Diabetes: TRE-T2D
open to eligible people ages 18-75
This is a randomized clinical trial to assess the feasibility and efficacy of time-restricted eating (TRE) to improve glucose regulation and cardiovascular health of participants with type 2 diabetes mellitus (T2DM). Participants will be randomized…
at UCSD
Treatment With COMS One Device in Subjects With Diabetic Foot Ulcers
open to eligible people ages 22-90
The purpose of this clinical trial is to evaluate the safety and effectiveness of the treatment with the COMS One device in subjects with refractory diabetic foot ulcers (DFUs). The prospective randomized, double-blinded, sham-controlled trial is…
at UCLA
Type 2 Diabetes and Blood Brain Barrier Improvement
open to eligible people ages 40-65
The majority of T2DM adults show thiamine (vitamin B1) deficiency which may contribute to impaired function. This study will examine patients with T2DM through brain MRI scans, cognition assessments, blood tests, and questionnaires. Our goal is to…
at UCLA
Commercial or Open Source Closed Loop Impact on Pregnancy Study
open to eligible females ages 18 years and up
The goal of this observational study is to better understand what happens when pregnant people with type 1 diabetes (T1D) use automated insulin delivery (AID) systems. The main questions this study aims to answer are: - What are the maternal and…
at UCSF
Designing Team Clinic for Youth with Type 2 Diabetes
open to eligible people ages 12-18
The goal of this clinical trial is to learn about if shared medical appointment is an acceptable way to deliver care to youth with type 2 diabetes. The main question[s] it aims to answer are: - Design four group activities centered around nutrition…
at UCSF
DFC 004 Biomarkers for Active Diabetic Foot Ulcers
open to eligible people ages 18 years and up
This study is a platform study designed to efficiently test multiple biomarkers to identify diabetic foot ulcers (DFUs) with a higher potential for healing versus not healing that ultimately could be applied at the point of care to drive…
at UCSF
Inflammation, Diabetes, Ethnicity and Obesity Cohort
open to eligible people ages 18-75
Obesity affects over one third of US adults (>72 million, with BMI ≥30 kg/m2), and the proportion of US adults with BMI ≥40 kg/m2 has doubled in the last 20 years. Obesity is associated with increased mortality through its linkage to comorbidities…
at UCSF
PS230005 Control-IQ 1.5 Post-Approval Study
open to eligible people ages 2-5
This 522 post-market surveillance study is a single-arm, decentralized prospective observational cohort study designed to collect safety data on Control-IQ technology v1.5 in children with type 1 diabetes ages 2 to <6 years old. Participants will…
at UCSD
TrialNet Pathway to Prevention of T1D
open to eligible people ages 2-45
Rationale: The accrual of data from the laboratory and from epidemiologic and prevention trials has improved the understanding of the etiology and pathogenesis of type 1 diabetes mellitus (T1DM). Genetic and immunologic factors play a key role in…
at UCLA UCSF
Type 1 Diabetes Extension Study
open to eligible people ages 8-35
This is a multi-center, prospective, non-interventional study that focuses on the long- term effects following participation in selected ITN new-onset Type1 Diabetes Mellitus studies with immunomodulatory agents (T1DM, T1D). This observational study …
at UCSF
Participants With Diabetic Retinopathy Without Center-involved Diabetic Macular Edema To Evaluate the Efficacy, Safety, and Pharmacokinetics of Ranibizumab Delivered Via the Port Delivery System Relative to the Comparator Arm
Sorry, in progress, not accepting new patients
Study GR41675 is a Multicenter, Randomized Study in Participants with Diabetic Retinopathy (DR) Without Center-Involved Diabetic Macular Edema (CI-DME) to Evaluate the Efficacy, Safety of the Port Delivery System with Ranibizumab (PDS) Relative to…
at UCLA
Shared Decision Making Intervention for Diabetes Prevention in Women With a History of Gestational Diabetes Mellitus
Sorry, in progress, not accepting new patients
Our goal is to test whether shared decision making for diabetes prevention can help women with a history of gestational diabetes mellitus (GDM) who are at high risk of developing type 2 diabetes (T2DM) increase weight loss and adoption of evidence…
at UCLA
Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk
Sorry, in progress, not accepting new patients
The main purpose of this study is to determine safety and efficacy of orforglipron compared with insulin glargine in participants with type 2 diabetes and obesity or overweight at increased cardiovascular risk. The study will last approximately 2…
at UCLA
Dulaglutide (LY2189265) 3.0 mg and 4.5 mg in Pediatric Participants With Type 2 Diabetes Mellitus (AWARD-PEDS PLUS)
Sorry, not currently recruiting here
The main purpose of this study is to evaluate additional dosing options for dulaglutide in pediatric participants with Type 2 Diabetes. Participation in this study will last about 8 months.
at UCLA UCSF
Oral Ladarixin in Recent Onset Type 1 Diabetes and a Low Residual β-cell Function
Sorry, in progress, not accepting new patients
Objectives The objective of this clinical trial is to assess whether ladarixin treatment has an effect to preserve β-cell function and delay the progression of T1D in adolescent and adult patients. The safety of ladarixin in the specific clinical…
at UCSD
Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes
Sorry, in progress, not accepting new patients
The purpose of the trial is to assess the efficacy and safety of tirzepatide to dulaglutide in participants with type 2 diabetes and increased cardiovascular risk.
at UCLA UCSD
Learn How Well Finerenone Works and How Safe it is in Adult Participants With Non-diabetic Chronic Kidney Disease
Sorry, in progress, not accepting new patients
Researchers are looking for a better way to treat people who have non-diabetic chronic kidney disease (non-diabetic CKD). The trial treatment, finerenone, is being developed to help people who have long lasting kidney disease, also known as chronic…
at UCLA
Achieving Routine Intervention and Screening for Emotional Health
Sorry, not yet accepting patients
The purpose of this project is to evaluate the effectiveness of diabetes distress screening and intervention on patients with type 2 diabetes mellitus (T2DM).
at UCSF
Automated Insulin for Management of Intrapartum Glycemia
Sorry, not yet accepting patients
The goal of this clinical trial is learn if automated insulin delivery (AID) systems can be used for glucose management during labor/delivery for pregnant people with type 1 diabetes (T1D). The main questions this study aims to answer are - What are …
at UCSF
CGM for Management of Type 2 Diabetes in Pregnancy
Sorry, not currently recruiting here
The goal of this clinical trial is to learn if continuous glucose monitoring works better than self-monitoring of blood glucose (fingersticks) to treat type 2 diabetes in pregnancy. It will also learn about all risk factors (biologic, personal,…
at UCSD
Changing Health Through Food Support for Diabetes
Sorry, in progress, not accepting new patients
This is a pragmatic randomized controlled trial (RCT) of Changing Health through Food Support for Diabetes (CHEFS-DM). This pragmatic RCT will leverage Project Open Hand's (POH) real-world programs to test the impact of a six month medically…
at UCSF
Autologous Intravitreal Bone-marrow CD34+ Stem Cells for Retinopathy
“We hope to learn more about the safety and feasibility of using your own (autologous) stem cells extracted from your bone marrow.”
Sorry, in progress, not accepting new patients
This pilot study is to determine whether it would be safe and feasible to inject CD34+ stem cells from bone marrow into the eye as treatment for patients who are irreversibly blind from various retinal conditions.
at UC Davis
Closed Loop and Education for Hypoglycemia Awareness Restoration
Sorry, not yet accepting patients
The purpose of the CLEAR study is to determine the effect on counterregulatory responses (CRR) of intervening (by attempting to strictly avoid hypoglycemia) to improve awareness of hypoglycemic symptoms among adults with type 1 diabetes (T1D) who…
at UCSD
Cryoneurolysis for Painful Diabetic Neuropathy of the Foot
Sorry, not yet accepting patients
The study is a single-center, randomized, participant- and observer-masked, human-subjects, post-market clinical pilot study to investigate the use of ultrasound-guided percutaneous cryoneurolysis to treat diabetic neuropathy of the foot. A…
at UCSD
Daily Blood Glucose Trends in Patients at Risk for Diabetes
Sorry, not yet accepting patients
The goal of this study is to learn about the relationship between blood sugar, diet, stress, and metabolic parameters including waist circumference, body mass index (BMI), cholesterol levels and blood pressure in patients at risk for diabetes. The…
at UCLA
DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes
Sorry, not currently recruiting here
This is a non-inferiority patient-centered and pragmatic comparative-effectiveness pregnancy randomized controlled trial (RCT) with postpartum maternal and child follow-up through 2 years of 1,572 individuals with gestational diabetes mellitus (GDM) …
at UCSF
Dexcom G6 Continuous Glucose Monitoring in Hemodialysis
Sorry, in progress, not accepting new patients
This is a pilot study enrolling adult hemodialysis patients with diabetes recruited from the University of California Irvine Medical Center (UCIMC) who will undergo simultaneous measurement of glucose levels using 1) continuous glucose monitor (CGM) …
at UC Irvine
Diabetes Autoimmunity Withdrawn In New Onset and In Established Patients
Sorry, in progress, not accepting new patients
The study is a prospective, randomized, 52-week double-blind, placebo-controlled, multicenter trial in subjects with T1D followed by a 2-year safety follow-up.
at UCSD UCSF
Diabetic Retinopathy Screening Point-of-Care Artificial Intelligence
Sorry, accepting new patients by invitation only
This research study is being conducted to improve eye care by using artificial intelligence (AI) to make diabetic eye screenings faster and more accessible. AI technology mimics human decision-making, enabling computers and systems to analyze…
at UCSD
GRA in Patients With Type 1
Sorry, in progress, not accepting new patients
This study will examine the effects a Glucagon Receptor Antagonist (GRA), has on Insulin Sensitivity, Cardiovascular risks (CVD), and Ketone body formation in participants with Type 1 diabetes. The participants will complete blood tests, tests to…
at UCSD
DMR Using the Revita® in Subjects With Inadequately Controlled Type 2 Diabetes
Sorry, currently not accepting new patients, but might later
The Revita® system is being investigated to assess the efficacy of DMR versus Sham on improvement in Glycemic, Hepatic and Cardiovascular endpoints for patients with Type 2 Diabetes who are inadequately controlled on one or more glucose lowering…
at UCLA
Exercise Study Testing Enhanced Energetics of Mitochondria Video Integrated Delivery of Activity Training in CKD
“Adults ages 30-80 with Chronic Kidney Disease can participate in a new exercise study to help improve muscle function. See if you qualify!”
Sorry, in progress, not accepting new patients
Skeletal muscle dysfunction (sarcopenia) is an under-recognized target organ complication of CKD with substantial adverse clinical consequences of disability, hospitalization, and death. Sarcopenia in this proposal is defined by impaired metabolism…
at UC Davis
Fully Closed Loop At Home (FCL@Home)
Sorry, in progress, not accepting new patients
Protocol Overview/Synopsis This study will be conducted at 3 sites, with each site performing a session with up to 6 participants with a lower HbA1c (<8.0%) in one of 3 age categories (26-60, 18-25, or 14-17 years) followed by a session of up to 6…
at UCSF
Glucagon Rescue of Insulin-Induced Hypoglycemia in Adults With Type 1 Diabetes Treated With Volagidemab
Sorry, not currently recruiting here
This trial is designed to evaluate the effect of glucagon receptor antagonism by volagidemab (once weekly) on glucose recovery from hypoglycemia after treatment with glucagon in adults with type 1 diabetes. After informed consent, Screening…
at UCSD
Team Clinic for Type 2 Diabetes (TCT2)
Sorry, not yet accepting patients
The goal of this clinical trial is to learn if shared medical appointment is an acceptable way to deliver care to youth with type 2 diabetes. The main question[s] it aims to answer are: - Is shared medical appointments an acceptable care delivery…
at UCSF
Islet Cell Transplant for Type 1 Diabetes
Sorry, in progress, not accepting new patients
City of Hope National Medical Center, located in Duarte, CA, is hosting a clinical study on islet cell transplantation, an experimental procedure being evaluated as a treatment for patients with type 1 diabetes. Islet cell transplantation involves…
at UCLA
Islet Transplantation With Recipient T-Reg Cells or Deceased Donor Vertebral Bone Marrow Therapy
Sorry, not yet accepting patients
The goal of this clinical trial is to learn if patients who have brittle type 1 diabetes receiving an islet transplantation will have better control of their sugars if they also receive one of 2 types of immune cells along with the islet transplant. …
at UCSF
Pancreatic Islets and Parathyroid Gland Co-transplantation for Treatment of Type 1 Diabetes
Sorry, in progress, not accepting new patients
The primary objective is to test the hypothesis that co-transplantation of allogeneic PTG with adult pancreatic islets (derived from same deceased donor) in the IM site in people with Type 1 diabetes with functioning kidney and/or liver transplants…
at UCSF
Personalized Comprehensive Diabetes Support for Children With Newly Diagnosed Type 1 Diabetes
Sorry, accepting new patients by invitation only
The goal of this clinical trial is to learn if access to a diabetes coach improves quality of life (QOL) for families of children with newly diagnosed type 1 diabetes. The main questions it aims to answer are: 1. Determine if there are beneficial…
at UC Davis
RAY121 in Immunological Diseases (RAINBOW Trial)
Sorry, not currently recruiting here
This Phase 1b basket trial will investigate the safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity and preliminary efficacy of RAY121, a inhibitor of classical complement pathway, after multiple dose administration in patients…
at UC Irvine
Plant-Focused Nutrition in Patients With Diabetes and Chronic Kidney Disease
Sorry, accepting new patients by invitation only
In this pilot clinical trial, the investigators will recruit and randomize 120 patients with diabetes mellitus and chronic kidney disease (CKD/DM) stages 3 to 5 to a patient-centered and flexible Plant-Focused Nutrition in Diabetes (PLAFOND) diet…
at UC Irvine UCLA
AT-001 in Patients With Diabetic Cardiomyopathy
Sorry, in progress, not accepting new patients
This is a multicenter, randomized, placebo-controlled, 2-part study to evaluate the safety and efficacy of AT-001 in adult patients (N=675) with Diabetic Cardiomyopathy at high risk of progression to overt heart failure.
at UC Irvine UCLA UCSD
Contezolid Acefosamil and Contezolid Compared to Linezolid Administered Intravenously and Orally to Adults With Moderate or Severe Diabetic Foot Infections (DFI)
Sorry, not currently recruiting here
This is a Phase 3, multicenter, randomized, double-blind, safety and efficacy study of contezolid acefosamil (IV)/contezolid (PO) compared with linezolid (IV and PO) administered for a total of 14 to 28 days in adult subjects with moderate or severe …
at UCLA
Siplizumab in T1DM
Sorry, in progress, not accepting new patients
This is a multicenter, Phase Ib, open-label, siplizumab dose-finding study in individuals aged 8-45 years with a Type 1 diabetes mellitus (T1DM) diagnosis. within 18 months of V0. Participants will be randomized 1:1:1:1 to one of four possible…
at UCSF
STOP-T1D Low-Dose (ATG)
Sorry, in progress, not accepting new patients
A multi-center, placebo-controlled, double blind, 2:1 randomized control clinical trial testing low-dose ATG vs. placebo in subjects with a 2 year 50% risk of progression to stage 3 T1D.
at UCSF
Strategies for Improving Linkage-to-Care After Eye Disease Screening
Sorry, not yet accepting patients
The goal of this randomized, parallel-group, controlled trial is to compare methods of enhancing linkage-to-care for participants in the Village Integrated Eye Worker II (VIEW II) trial who are referred to the eye hospital following eye disease…
at UCSF
Student Pharmacist Non-Pharmacological Intervention on Type 2 Diabetes Management in Older Asian Adult Populations
Sorry, not yet accepting patients
This study is being done to assess the impact of student pharmacist involvement on blood glucose control through non-pharmacological interventions in people of Asian and Asian descent over the age of 50 with type 2 diabetes. This study team is…
at UCSF
Understand Risk Information to Support and Empower
Sorry, accepting new patients by invitation only
The aim of this trial is to test components of a digital health outreach intervention to promote uptake of postpartum screening and lifestyle programs for diabetes prevention among patients with gestational diabetes (GDM). The outreach intervention, …
at UC Davis
Suppression of Endogenous Glucose Production by Injectable HDV-Insulin Lispro: A Dose Response Study in Human Subjects With Type 1 Diabetes
Sorry, not yet accepting patients
Single-center, double-blind, random-sequence study assessing the HDV dose-response relationship to Endogenous Glucose Production (EGP), Free Fatty Acids (FFA) and Glucose Disposal Rate (GDR) during a euglycemic clamp procedure following overnight…
at UCSD
SYNERGY PLUS: Evaluation of Next Generation Sensors (NGS) and Algorithm in Patients with Type 1 and Type 2 Diabetes
Sorry, not yet accepting patients
The purpose of this study is to find out how well a new continuous glucose monitor works for people with diabetes. This study will test the performance of the study sensor(s) for 7-14 days of wear in patients who are 11-80 years old with type 1 or…
at UCSF
T-UP: Engaging Vulnerable Students in Diabetes Prevention
Sorry, in progress, not accepting new patients
The goal of this study is to enhance reach and uptake of diabetes prevention among young adults, with a focus on recruiting underserved and high-need students who face additional challenges, including food and financial insecurity. The specific aims …
at UCLA
Teplizumab in Pediatric Stage 2 Type 1 Diabetes
Sorry, in progress, not accepting new patients
The purpose of this study is to assess the safety and pharmacokinetics (PK) of teplizumab in participants with Stage 2 type 1 diabetes who are <8 years of age.
at UCSF
THC Effects on Glucose in Type 2 Diabetes
Sorry, not yet accepting patients
This study will examine the effects THC has on Glucose Metabolism and Endothelial Functioning in participants with Type 2 Diabetes. The participants will complete blood tests and tests to measure energy expenditure, CVD risks, and glucose…
at UCSD
Lifestyle Education About Nutrition for Diabetes (Legend) Study
Sorry, in progress, not accepting new patients
This study is being completed to compare two dietary approaches for participants with type 2 diabetes. This research will test whether a very low-carbohydrate or a plate-method diet better improves outcomes for blood glucose control and body…
at UCSF
Time Restricted Eating in Patients with Microalbuminuria
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This is a clinical trial to assess how time-restricted eating (TRE) may improve kidney health and filtration patients with type 2 diabetes and increased protein content in their urine. All participants will be participating in TRE in which they…
at UCSD
Treatment of Type I Diabetes by Islet Transplantation Into the Gastric Submucosa Study Protocol
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The goal of this trial is to gain initial clinical experience regarding the safety and efficacy of treating type I diabetes in people who have received a kidney transplant by transplanting islets into a new transplant site in the stomach…
at UCSF
UCLA Health Patient Health Maintenance Outreach Text Message
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This is a prospective randomized clinical trial evaluating how behaviorally-informed outreach text messages impact patient engagement with primary care. This prospective randomized control trial is being implemented in conjunction with UCLA Health's …
at UCLA
UCLA Health Patient Health Maintenance Text Reminder
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This is a prospective randomized clinical trial evaluating how behaviorally-informed outreach text message reminders impact patient engagement with primary care. This prospective randomized control trial is being implemented in conjunction with UCLA …
at UCLA
UCLA Health Patient Health Maintenance Text Reminder July 2023
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This is a prospective randomized clinical trial evaluating how behaviorally-informed outreach text message reminders impact patient engagement with primary care. This prospective randomized control trial is being implemented in conjunction with UCLA …
at UCLA
UCLA Health Patient Health Maintenance With Interactive Text Reminder
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This is a prospective randomized clinical trial evaluating how behaviorally-informed outreach text message reminders impact patient engagement with primary care. This prospective randomized control trial is being implemented in conjunction with UCLA …
at UCLA
Wearable Sensors To Understand Low Blood Sugar in Type 1 Diabetes
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This is a single-site study using wearable sensor technology (CGM and smartwatch) to better explain low blood sugars in patients living with type 1 diabetes. Up to 20 participants with T1D will wear a continuous glucose monitor (CGM) and a…
at UCSD
AI Ready and Exploratory Atlas for Diabetes Insights
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The study will collect a cross-sectional dataset of 4000 people across the US from diverse racial/ethnic groups who are either 1) healthy, or 2) belong in one of the three stages of diabetes severity (pre-diabetes/diet controlled, oral medication…
at UCSD
Cardiovascular Health Study (CHS)
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To determine the extent to which known risk factors predict coronary heart disease and stroke in the elderly, to assess the precipitants of coronary heart disease and stroke in the elderly, and to identify the predictors of mortality and functional…
at UC Davis
Elucidation of Breast Milk Composition and Structure Over the First Year of Lactation: UC Davis Lactation Study
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This observational study is designed to determine how sugars, lipids and proteins in breast milk vary among mothers; is affected by maternal diet, health and microbiota and vary over the course of lactation. Additionally, the study is designed to…
at UC Davis
HLA Demographics Study in Adults With Type 1 Diabetes
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This is a study to evaluate the HLA-DRB1*04:01 genotype in adults that have been diagnosed with type 1 diabetes
at UCSF
MIRACLE of LIFE Study
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The goal of this observational study is to develop and validate cell-free RNA-based biomarkers for predicting a variety of adverse pregnancy outcomes in a pregnant person population. The main question it aims to answer are: 1. Can cell-free…
at UCSD
Predicting Diabetic Retinopathy From Risk Factor Data and Digital Retinal Images
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The objective of this study is to compare the results of a deep learning approach to diabetic retinopathy assessment with results from (1) an in-person examination with an ophthalmologist, and (2) the assessments of optometrists involved in a…
at UCLA
Recent-Onset Type 1 Diabetes Extension Study Evaluating the Long-Term Safety of Teplizumab (PROTECT Extension)
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The purpose of this non-interventional extension study is to continue to collect long-term safety and other clinical data for an additional 42 months in participants who completed the PROTECT study.
at UCSF
Diabetes Prevention Program Outcomes Study AD/ADRD Project
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The DPPOS AD/ADRD project will address the overarching question: What are the determinants and the nature of cognitive impairment among persons with pre-diabetes (PreD) and type 2 diabetes (T2D), who are a high-risk group for cognitive impairment…
at UCLA UCSD
Our lead scientists for Diabetes research studies include Crystal Zhou, PharmD Calvin H. Hirsch, MD Steven D. Mittelman, MD, PhD Pam Taub, MD Kyung Rhee, MD, MS, MA Karen L Lindsay, RD, PhD Tannaz Moin, MD,MBA,MSHS Matthew A Budoff, MD Jeremy Pettus, MD Jenise C Wong, MD, PhD Shylaja Srinivasan, MD, MAS Vincent L. Rowe, MD Michael Conte, MD Delphine Tuot Susan D Brown, PhD Edward C Chao, DO Nicole Stadnick, PhD Susanna s Park, MD PhD Javier Lopez, MD Rajesh Kumar, PHD David Kunkel Schafer Boeder, MD Carlito Lebrilla, PhD Laya Ekhlaspour, MD Sammy Elmariah, MD, MPH Karol Watson, MD, PhD Rohit Loomba Baback Roshanravan, MD Vijiya Surampudi, MD Rodney Gabriel Stephen Gitelman Lauren Wisk, PhD Jeremy Keenan, MD, MPH Peter Stock, MD, PhD David K Johnson, PhD Stephanie Crossen, MD, MPH Ashley Miller, MD Suneil Koliwad, MD,PhD Lauren E Gyllenhammer, PhD Carl Hoh, MD Helen Raybould, PhD Richard K. Leuchter, MD Andrew M Posselt, MD, PhD Bart Weimer, PhD Nathaniel Schuster, MD Christina S. Han, MD Estelle M. Everett, MD Adarsh M. Thaker, MD Nasim Sobhani, MD Dianne S. Cheung, MD, MPH.
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