Summary

Eligibility
for females ages 18 years and up (full criteria)
Location
at UCSD
Dates
study started
completion around

Description

Summary

RATIONALE: Drugs used in chemotherapy, such as cisplatin, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known whether chemotherapy and radiation therapy are more effective when given with or without additional chemotherapy in treating cervical cancer.

PURPOSE: This randomized phase III trial is studying chemotherapy and pelvic radiation therapy to see how well they work when given with or without additional chemotherapy in treating patients with high-risk early-stage cervical cancer after radical hysterectomy.

Official Title

Phase III Randomized Study of Concurrent Chemotherapy and Pelvic Radiation Therapy With or Without Adjuvant Chemotherapy in High-Risk Patients With Early-Stage Cervical Carcinoma Following Radical Hysterectomy

Details

Keywords

Cervical Cancer, cervical adenocarcinoma, cervical adenosquamous cell carcinoma, cervical squamous cell carcinoma, stage IA cervical cancer, stage IB cervical cancer, stage IIA cervical cancer, Uterine Cervical Neoplasms, Paclitaxel, Carboplatin, cisplatin, intensity-modulated radiation therapy, Optional brachytherapy boost, Cisplatin/Radiation Therapy, Cisplatin/Radiation Therapy + Carboplatin/Paclitaxel

Eligibility

Locations

Details

Status
in progress, not accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Radiation Therapy Oncology Group
ID
NCT00980954
Phase
Phase 3 Cervical Cancer Research Study
Study Type
Interventional
Participants
About 236 people participating
Last Updated