Mild Cognitive Impairment clinical trials at University of California Health
26 in progress, 17 open to eligible people
AAV2-BDNF Gene Therapy in Early Alzheimer's Disease and Mild Cognitive Impairment
open to eligible people ages 50-80
This is a first-in-human clinical trial to test whether a protein administered into the brain continuously by gene therapy, Brain-Derived Neurotrophic Factor (BDNF), will slow or prevent cell loss in the brains of people affected by Alzheimer's…
at UCSD
Senicapoc in Alzheimer's Disease
“Volunteer for research and contribute to discoveries that may improve health care for you, your family, and your community!”
open to eligible people ages 55-85
Development of novel disease-modifying therapies for Alzheimer's disease (AD) remains of paramount importance. This study will be a Phase II randomized clinical trial testing Senicapoc in patients with mild or prodromal AD. This will be a small…
at UC Davis
Accelerating Cognitive Gains From Digital Inverventions With Noninvasive Brain Stimulation
open to eligible people ages 60-85
The overall goal of this project is to collect pilot feasibility and early efficacy data showing improvements in cognition and wellbeing in adults with mild cognitive impairment (MCI) through a combination treatment of non-invasive brain stimulation …
at UCSF
Brain Health Virtual Reality Study
open to eligible people ages 50-85
The Interventions for Brain Health Virtual Reality Study is a NIH-funded clinical research trial at the University of California San Diego (UCSD) Health under the supervision of the study principal investigator Dr. Judy Pa. The overarching goal of…
at UCSD
Enhancing Attention and Wellbeing Using Digital Therapeutics
open to eligible people ages 60-99
The goals of the proposed research are to first determine the minimal and/or optimal dose of a digital intervention required for cognitive enhancement, and then to examine the impact of several potential moderators of treatment effects (i.e.,…
at UCSF
Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease
open to eligible people ages 50-90
The goal of this study is to investigate whether Low Intensity Focused Ultrasound Pulsation (LIFUP) targeting a part of the brain involved in memory will have an affect on brain activity and whether it may improve memory in people with Mild…
at UCLA
Music Improvisation Training on Cognitive Function in Older Adults
open to eligible people ages 60 years and up
This project will study the effects and mechanisms of a music improvisation training intervention on self-regulation of older adults with and without MCI. The investigator's overall hypothesis is that improvisation training will lead to improvements …
at UCSF
Network-targeted Theta-burst Stimulation for Episodic Memory Improvement in Mild Cognitive Impairment
open to eligible people ages 55-100
The purpose of this study is to see if stimulation of the brain can improve memory. The investigators will use a device called transcranial magnetic stimulation that can stimulate and activate a specific part of the brain that is important for…
at UCLA
Neurofeedback to Improve Working Memory in Mild Cognitive Impairment
open to eligible people ages 50-85
Mild cognitive impairment (MCI) has been identified as an early phase of Alzheimer's disease (AD), a neurodegenerative disorder expected to affect 13.9 million Americans by 2060. AD causes a progressive cognitive decline, including problems related…
at UCSD
Digital Interventions on Cognition, Wellbeing, Stress, and Sleep in Older Adults
open to eligible people ages 60-85
The goal of this proposed research is to collect pilot data to test the hypothesis that treatment with a novel form of closed-loop digital meditation (MediTrain) will lead to a greater magnitude of gains in cognitive abilities in patients with mild…
at UCSF
TabCAT Brain Health Assessment in Primary Care
open to eligible people ages 18 years and up
Efficient and user-friendly paradigms to detect cognitive impairment, including dementia are needed in primary care. The TabCAT Brain Health Assessment accurately detects cognitive impairment via an appealing tablet interface with automated scoring…
at UCSF
Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia
open to eligible people ages 55-89
Older adults at risk for dementia show a variety of cognitive deficits, which can be ameliorated by different cognitive training (CT) exercises. The best combination of CT exercises is unknown. The aim is to discover the most efficacious combination …
at UCSF
Wayfinding Intervention and Long-Term Memory
open to eligible people ages 60-85
Therapeutic treatment is yet available for declining memory, which is an impairment affecting the quality of life for many older adults and patients with cognitive impairment. Cognitive training with an immersive video game promises to drive…
at UCSF
Alzheimer's Disease Neuroimaging Initiative 4
open to eligible people ages 55-90
Since its launch in 2004, the overarching aim of the Alzheimer's Disease Neuroimaging Initiative (ADNI) Study has been to validate biomarkers for Alzheimer's disease (AD) clinical trials. ADNI4 continues the previously funded ADNI1, ADNI-GO, ADNI2,…
at UC Davis UC Irvine UCLA UCSD UCSF
Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
open to eligible people ages 18 years and up
The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke. The purpose of the study is to help doctors identify patients …
at UCLA UCSD
Longitudinal Early-onset Alzheimer's Disease Study Protocol
open to eligible people ages 40-64
The Longitudinal Early-onset Alzheimer's Disease Study (LEADS) is a non-randomized, natural history, non-treatment study designed to look at disease progression in individuals with early onset cognitive impairment. Clinical, cognitive, imaging,…
at UCLA UCSF
Remote Cognitive Assessment for Surgical Patients
open to eligible people ages 65-99
This is a pilot study to evaluate the use of remote cognitive testing to identify patients who may have cognitive vulnerability and may benefit from cognitive care pathways. Participants in this study are asked to complete a smartphone battery of…
at UCSF
Learn About the Safety of BIIB080 Injections and Whether They Can Improve Symptoms of Participants With Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD Dementia Between 50 to 80 Years of Age
Sorry, in progress, not accepting new patients
In this study, researchers will learn more about a study drug called BIIB080. The study will focus on participants with mild cognitive impairment or mild dementia due to AD. The main question researchers are trying to answer is if BIIB080 can slow…
at UCLA UCSD UCSF
Assessing and Improving the Durability of Compensatory Cognitive Training for Older Veterans
Sorry, accepting new patients by invitation only
Veterans have numerous risk factors (e.g., PTSD, TBI, cerebrovascular problems) for later-life cognitive and functional decline. Evidence supports the effectiveness of strategy-based cognitive rehabilitation therapies, including compensatory…
at UCSD
Epileptic Hippocampus in Alzheimer's Disease
Sorry, not yet accepting patients
The major goals of the study are to 1) characterize hippocampal activity in patients with mild cognitive impairment (MCI) due to Alzheimer's disease (AD) and AD who have suspected hippocampal epileptic activity based on scalp EEG recordings from IRB …
at UCLA
Metformin in Alzheimer's Dementia Prevention
Sorry, in progress, not accepting new patients
MAP will be a multisite phase II/III 1:1 randomized controlled trial (RCT) of long acting metformin (reduced mass Glucophage XR) vs. matching placebo in 326 men and women with early and late aMCI, without diabetes, not treated with metformin,…
at UC Irvine
Multi-domain Online Therapeutic Investigation Of Neurocognition (MOTION)
Sorry, in progress, not accepting new patients
The purpose of this study is to compare the effects of three on-line wellness interventions for improving physical and cognitive function and brain connectivity in adults who are at least 55 years old and are experiencing symptoms of memory and/or…
at UCLA UCSF
Digital Memory Notebook
Sorry, accepting new patients by invitation only
Compensatory aids (e.g., alarms, calendars) play an important supporting role when completing everyday tasks (e.g., appointments, medication management), and there is a growing body of scientific work suggesting that compensatory training improves…
at UC Davis
TREAD: Time Restricted Eating Intervention for Alzheimer's Disease
Sorry, not yet accepting patients
The goal of this clinical trial is to learn if restricting the time of eating to allow for prolonged fasting at night may reduce sleep disturbances, cognitive decay, and pathology in patients diagnosed with Mild Cognitive Impairment (MCI) or early…
at UCSD
Can (Optical Coherence Tomography) Pictures of the Retina Detect Alzheimer's Disease at Its Earliest Stages?
Sorry, accepting new patients by invitation only
Years before someone experiences the symptoms of Alzheimer's disease, a compound called amyloid beta (Aβ) builds up in the brain. Excess Aβ - directly or indirectly - causes many of the symptoms of Alzheimer's dementia. However, recent studies of…
at UC Davis
Living Alone in Old Age With Cognitive Impairment
Sorry, in progress, not accepting new patients
The purpose of this study is to better understand the experience of living alone in older age with cognitive impairment. We recruit adults 55+ living alone with cognitive impairment such as Alzheimer's disease or mild cognitive impairment. This…
at UCSF
Our lead scientists for Mild Cognitive Impairment research studies include Gil Rabinovici, MD Paula Desplats, PhD Adam Staffaroni, PhD Elena Portacolone, PhD MPH MBA David Ziegler, PhD Mario Mendez, MD, PhD Katherine Mun, MD Joel Kramer, PhD Linda L Chao, PhD Sarah Farias, PhD Katherine Possin, PhD Brett Meyer, MD Adam Gazzaley, MD/PhD John Olichney, MD Nanthia Suthana Odmara Barreto Chang, MD, PhD Fiza Singh Mark Tuszynski, M.D., Ph.D. Peter E Wais, PhD Susan Y Bookheimer, PhD Julene Johnson, PhD Jacqueline E Maye, PhD Judy Pa.
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