Summary

Eligibility
for people ages 60-90 (full criteria)
Healthy Volunteers
healthy people welcome
Location
at UCLA
Dates
study started
estimated completion
Principal Investigator
by Nanthia Suthana (ucla)

Description

Summary

The purpose of this study is to see if stimulation of the brain can improve memory. The investigators will use a device called transcranial magnetic stimulation that can stimulate and activate a specific part of the brain that is important for memory. The study will enroll MCI and normal age matched control subjects with and without genetic risk for AD who will be randomly assigned to receive active or sham brain stimulation. 'Blinded' or 'sham-controlled' means that the subject will not know whether the treatment they receive is the active treatment or the non-active stimulation. In the 'sham' condition, the stimulator will turn on but will not actually be stimulating the target brain region.

Keywords

Cognitive Dysfunction Memory Disorders in Old Age Memory Disorders Active Theta Burst Stimulation

Eligibility

You can join if…

Open to people ages 60-90

  • 60-90 years of age
  • Willing to provide informed consent and participate in a longitudinal study
  • In good general health
  • MoCA (Montreal Cognitive Assessment Test) >25
  • Ability to read and write English fluently
  • Adequate visual and auditory acuity to allow neuropsychological testing
  • Screening laboratory/ECG without abnormalities that might interfere with the study
  • Diagnosis of mild neurocognitive disorder according to DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) criteria

You CAN'T join if...

  • Diagnosis of dementia
  • Active major psychiatric or neurologic disorders
  • Active alcohol or substance abuse
  • Recent (< 6 months) alcohol or substance abuse excluding nicotine or caffeine
  • Active or history of stroke, traumatic brain injury with loss of consciousness, or other neurologic disorder (e.g., Epilepsy, Huntington's disease, Parkinson's disease)
  • Not a native English Speaker
  • Not right handed based on self-report or evaluation based on a standard report
  • Has received TMS before (not TMS naïve)
  • Head trauma or systemic diseases affecting brain function
  • Uncontrolled hypertension or cardiovascular disease
  • Use of any memory-enhancing medication (e.g., memantine, cholinesterase inhibitor), supplement (e.g., ginkgo biloba), or psychotropic medication for treatment of depression, anxiety, or psychosis.
  • Current enrollment in a memory-enhancement study or course
  • Contraindication to the MRI including claustrophobia, metal in body, surgery within 60 days, certain implants or previous abnormal MRI results.

Location

  • University of California Los Angeles accepting new patients
    Los Angeles California 90024 United States

Lead Scientist at UC Health

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, Los Angeles
ID
NCT04558164
Study Type
Interventional
Last Updated