Summary

for females ages 50-90 (full criteria)
at UCLA
study started
estimated completion
Helen Lavretsky (ucla)

Description

Summary

The purpose of this pilot study will be to test whether Kundalini yoga (KY) and Kirtan Kriya (KK) yogic meditation is superior to Memory Enhancement Training (MET) for improving cognitive functioning, health (including cardiovascular factors), and mood in women with high AD risk.

Details

Overall, the investigators anticipate recruiting 100 women (50 or older) with MCI and high Alzheimer's disease risk. Subjects will either receive: (1) MET class for 60 minutes per week; or (2) Kundalini yoga and "Kirtan Kriya" meditation class for 60 minutes per week. Assessments will be completed immediately after the interventions at 6 and 12 weeks and follow-up visits at week 24 and 48 to monitor the overall benefit of the intervention.

Keywords

Mild Cognitive Impairment Alzheimer's Disease Memory impairment Meditation Yoga Memory Training MCI Geriatric fMRI Cardiovascular risk Alzheimer Disease Cognitive Dysfunction Kundalini yoga and meditation

Eligibility

You can join if…

Open to females ages 50-90

  1. Amnestic MCI, as defined by a Clinical Dementia Rating Scale score of .5.
  2. High cardiovascular risk defined as at least one of the following:
  3. 7.5 percentile risk or higher using ASCVD risk calculator
  4. Myocardial Infarction more than 6 months ago
  5. Diabetes
  6. Taking medication for blood pressure > 140/90 blood pressure
  7. Taking medication for lyperlipidemia LDL >160
  8. Sufficient English proficiency and the 8th grade or higher reading level as determined by the word reading subtest of the Wide Range Achievement Test-IV (this criterion is necessary in order to ensure ability to participate in MET, which involves reading and writing and has a Flesch-Kinkaid school equivalency of 7th grade)
  9. Capacity to provide informed consent

You CAN'T join if...

  1. History of psychosis, bipolar disorder, alcohol/ drug dependence, or neurological disorder
  2. Recent (within three months) surgery, anticipated surgery within next year, or unstable medical condition
  3. Any disability preventing participation in MET or KK+KY (e.g., severe visual or hearing impairment)
  4. Insufficient English proficiency to participate in either MET or KK+KY
  5. Diagnosis of dementia
  6. Mini Mental Health Examination score of 23 or below
  7. Currently taking any psychoactive medication
  8. Participation in a psychotherapy that involves cognitive training
  9. Practice of Kundalini Yoga or Kirtan Kriya within the past year
  10. . Myocardial Infarction within the past 6 months

Location

  • UCLA Semel Institute accepting new patients
    Los Angeles California 90095 United States

Lead Scientist

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, Los Angeles
ID
NCT03503669
Study Type
Interventional
Last Updated