Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at UC Davis UC Irvine UCSF
Dates
study started
completion around
Principal Investigator
by Antonio Frangieh, MD (uci)Sammy Elmariah, MD (ucsf)
Headshot of Sammy Elmariah
Sammy Elmariah

Description

Summary

To establish the safety and effectiveness of the Edwards PASCAL Transcatheter Valve Repair System in patients with degenerative mitral regurgitation (DMR) who have been determined to be at prohibitive risk for mitral valve surgery by the Heart Team, and in patients with functional mitral regurgitation (FMR) on guideline directed medical therapy (GDMT)

Official Title

Edwards PASCAL TrAnScatheter Valve RePair System Pivotal Clinical Trial (CLASP IID/IIF): A Prospective, Multicenter, Randomized, Controlled Pivotal Trial to Evaluate the Safety and Effectiveness of Transcatheter Mitral Valve Repair With the Edwards PASCAL Transcatheter Valve Repair System Compared to Abbott MitraClip in Patients With Mitral Regurgitation

Details

A prospective, multicenter, randomized, controlled pivotal trial to evaluate the safety and effectiveness of transcatheter mitral valve repair with the Edwards PASCAL Transcatheter Valve Repair System compared to Abbott MitraClip in patients with degenerative mitral regurgitation (DMR) who have been determined to be at prohibitive risk for mitral valve surgery by the Heart Team, and in patients with functional mitral regurgitation (FMR) on guideline directed medical therapy (GDMT)

Patients will be seen for follow-up visits at discharge, 30 days, 6 months, and annually through 5 years.

Keywords

Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation, Mitral Valve Insufficiency, Edwards PASCAL System, Abbott Mitraclip System, Edwards PASCAL System - CLASP IID, Abbott Mitraclip System - CLASP IID, Edwards PASCAL System - CLASP IIF, Abbott Mitraclip System - CLASP IIF

Eligibility

You can join if…

Open to people ages 18 years and up

  • Eighteen (18) years of age or older
  • Patient is able and willing to give informed consent and follow protocol procedures, and comply with follow-up visit requirements.
  • Patient is determined to be at prohibitive risk for mitral valve surgery by the heart team (CLASP IID cohort only).
  • Patient is on stable heart failure medications/Guideline Directed Medical Therapy (CLASP IIF cohort only)
  • Patient is determined to be a candidate for transcatheter mitral valve repair by the heart team for both PASCAL and MitraClip
  • Mitral regurgitation (3+ to 4+) by echo
  • Suitable valve and regurgitant jet morphology
  • Elevated corrected BNP > 400 pg/ml or corrected NT-pro BNP of > 900 pg/ml or heart failure hospitalization within the past 12 months (CLASP IIF cohort only)
  • LVEF ≥ 20% (and ≤ 50%; CLASP IIF cohort only)

You CAN'T join if...

  • Patient in whom a TEE is contraindicated or screening TEE is unsuccessful
  • Mitral valve anatomy which may preclude proper PASCAL or MitraClip access, use and/or deployment or sufficient reduction in mitral regurgitation
  • Patient with refractory heart failure requiring advanced intervention (i.e. left ventricular assist device, Status ≤5 heart transplantation) (ACC/AHA Stage D heart failure)
  • Clinically significant, untreated coronary artery disease
  • Recent stroke
  • Other severe valve disorders requiring intervention
  • Need for emergent or urgent surgery for any reason or any planned cardiac surgery within the next 12 months
  • Any prior mitral valve surgery or transcatheter mitral valve procedure (excluding chordal replacement or surgical annuloplasty repair)
  • Severe tricuspid regurgitation or tricuspid valve disease requiring surgery
  • Active rheumatic heart disease or rheumatic etiology for MR
  • Severe aortic stenosis or regurgitation
  • Known history of untreated, severe carotid stenosis
  • Recent deep vein thrombosis (DVT) or pulmonary embolism (PE)
  • Severe COPD
  • Pregnant or planning pregnancy within next 12 months. Note: Female patients of childbearing potential need to have a negative pregnancy test performed within 14 days prior to intervention and be adherent to an accepted method of contraception
  • Concurrent medical condition with a life expectancy of less than 12 months in the judgment of the Investigator
  • Patient is currently participating in another investigational biologic, drug or device clinical study where the primary study endpoint was not reached at time of enrollment
  • Other medical, social, or psychological conditions that preclude appropriate consent and follow-up, including patients under guardianship

Locations

  • UC Irvine accepting new patients
    Orange California 92868 United States
  • UC Davis Medical Center withdrawn
    Sacramento California 95817 United States
  • UC San Francisco accepting new patients
    San Francisco California 94143 United States
  • University of California, San Francisco accepting new patients
    San Francisco California 94143 United States
  • Sutter Medical Center-Sacramento accepting new patients
    Sacramento California 95618 United States
  • Kaiser Permanente San Francisco accepting new patients
    San Francisco California 94118 United States
  • Sutter Bay Area in progress, not accepting new patients
    San Francisco California 94109 United States
  • Cedars Sinai Medical Center accepting new patients
    Los Angeles California 90048 United States
  • PIH Health Good Samaritan Hospital accepting new patients
    Los Angeles California 90017 United States
  • St. Joseph Hospital accepting new patients
    Orange California 92868 United States

Lead Scientists at University of California Health

  • Antonio Frangieh, MD (uci)
    Associate Clinical Professor, Medicine, School of Medicine
  • Sammy Elmariah, MD (ucsf)
    Dr. Sammy Elmariah is an interventional cardiologist who specializes in caring for patients with heart valve disease, coronary artery disease, and adult congenital heart disease.

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Edwards Lifesciences
ID
NCT03706833
Study Type
Interventional
Participants
Expecting 1247 study participants
Last Updated