Summary

for people ages 18-62 (full criteria)
healthy people welcome
at UCSF
study started
estimated completion
Aric A Prather, PhD(ucsf)

Description

Summary

This study will test the effect of race-based social rejection on polysomnography derived sleep outcomes and nocturnal cardiovascular psychophysiology in a sample of 80 African Americans and 80 Caucasian Americans. The investigators will test group differences on these outcomes as well as within subjects by testing impact of rejection compared to a non-rejection control night in the sleep laboratory.

Official Title

The Effects of Social Experiences on Sleep and Cardiovascular Functioning

Details

African Americans (AA) are disproportionally burdened by cardiovascular disease compared to Caucasian Americans (CA). Poor sleep, which is more common among AA, may serve as an important pathway in understanding these disparities. Race-based rejection has been cross-sectionally related to poor sleep and negative cardiovascular outcomes. To test the links between social experiences and sleep, participants will spend two nights in the sleep laboratory. One night will be a control night where participants complete low arousal tasks prior to bedtime. On a second night, the investigators will randomize 80 AA and 80 CA to either race-based social rejection (i.e., being rejected by an out-group member) or same-race social rejection prior to bedtime to test the causal influences of race-based rejection on objective sleep parameters, measured using polysomnography, and nocturnal cardiovascular functioning. The investigators will test group differences on these outcomes as well as within subjects by testing impact of rejection compared to a non-rejection control night in the sleep laboratory. The order of the control and rejection task night will be counterbalanced.

Keywords

Sleep Blood Pressure heart stress Social rejection

Eligibility

You can join if…

Open to people ages 18-62

  • Age: 18 to 62 years old
  • Self-identified as African American/Black or Caucasian American/White
  • English speaking, able to provide consent
  • Self-reported bedtime between 10PM and 12AM for 5/7 nights for the past 3 months (stability to be confirmed by sleep diary and wrist actigraphy).
  • Self-reported sleep duration between 6.5 and 8.5 hours for 5/7 nights for the last month (duration to be confirmed by actigraphy and sleep diary)

You CAN'T join if...

  • Body mass index of 40 or above
  • Participants at high risk for obstructive sleep apnea, based on "high risk" score from the STOP-Bang.
  • Medical or psychiatric condition, as assessed by self-report and clinical interview that affect sleep and/or cardiovascular functioning, including doctor diagnosed arrhythmia, hypertension, congestive heart failure, major depression, bipolar disorder, post-traumatic stress disorder.
  • Medication use that is likely to affect sleep and/or cardiovascular functioning, including antidepressants, anxiolytic or soporific medication, and beta-blockers.

Location

  • University of California, San Francisco accepting new patients
    San Francisco California 94118 United States

Lead Scientist

  • Aric A Prather, PhD (ucsf)
    Associate Professor, Psychiatry. Authored (or co-authored) 64 research publications

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT03937973
Study Type
Interventional
Last Updated