for people ages 21-35 (full criteria)
Healthy Volunteers
healthy people welcome
study started
estimated completion
Principal Investigator
by Mary Rezk-Hanna (ucla)



In the United States, exposure to secondhand smoke accounts for greater than 35,000 deaths annually from cardiovascular disease in never-smokers. Electronic (e-) hookahs are a new category of vaping devices gaining popularity among youth. While more is known on the acute effects of active hookah smoking and the literature is emerging on active e-hookah vaping, virtually nothing is known about the acute cardiovascular effects of secondhand exposure to e-hookah aerosol. The study aims to examine the acute effects of secondhand exposure of e-hookah aerosol on endothelial and vascular function. Eligible volunteers will be invited to participate in a total of 2 study visits (2-4 hours each): exposure to e-hookah aerosol delivered by a hookah smoking/vaping machine, and for comparison, before and after clean air. Non-invasive blood pressure and blood flow measurements will be taken before and after the exposure sessions.

Official Title

Investigating Secondhand Effects of E-Hookah Aerosol


Hookah Smoking Secondhand Aerosol Vascular Stiffness Vaping e-hookah aerosol clean air Peripheral Endothelial Function Central Arterial Stiffness


You can join if…

Open to people ages 21-35

  • 21-35 years old
  • Never a smoker: do not use any tobacco products or nicotine delivery systems, including cigarettes, cigars (traditional and filtered), cigarillos, hookah, smokeless tobacco (i.e., loose snus, moist snuff, dip, spit, or chewing tobacco), pipe tobacco, snus pouches, dissolvable tobacco or vaping.
  • no evidence of cardiopulmonary disease by history/physical
  • blood pressure (BP) < 140/90 mmHg
  • resting heart rate (HR) < 100 bpm
  • BMI >18 or < 30kg•m2
  • no prescription medication
  • No exposure to environmental tobacco smoke for at least one week prior to the study date.

You CAN'T join if...

  • exhaled carbon monoxide >6 ppm
  • (+) pregnancy test
  • other conditions deemed unsafe to participate, such as breastfeeding


  • University of California, Los Angeles accepting new patients
    Los Angeles California 90095-8361 United States

Lead Scientist at University of California Health


accepting new patients
Start Date
Completion Date
University of California, Los Angeles
Study Type
Last Updated