for people ages 21-49 (full criteria)
Healthy Volunteers
healthy people welcome
study started
completion around
Principal Investigator
by Mary Rezk-Hanna, PhD (ucla)



In the United States, secondhand smoke is the third leading preventable cause of death. Flavored hookah (waterpipe) tobacco smoking, a highly social activity common in hookah bars, is a key source of SHS exposure. While smoke-free air laws have decreased exposure to secondhand smoke, the majority of laws do not include hookah smoking. Thus, as a social outlet for youth and young adults, hookah smoke exposure may harm non-smokers, including women of reproductive age or pregnant, hookah bar workers, children, and individuals with heart and lung disease. While more is known on the acute effects of active hookah smoking and the literature is emerging on active e-hookah vaping, little is known about the acute vascular effects of secondhand exposure to hookah smoke and aerosol. The study aims to examine the acute effects of secondhand exposure of hookah smoke and aerosol on endothelial and vascular function. Eligible volunteers will be invited to participate in a total of 3 study visits (2-3 hours each): e-hookah aerosol exposure, charcoal-heated hookah smoke exposure and smoke-free room air. Non-invasive blood pressure and blood flow measurements will be taken before and after the exposure sessions.

Official Title

Investigating the Secondhand Effects of Hookah Smoking and Vaping


Hookah Smoking, Secondhand Aerosol, Vascular Stiffness, Vaping, Combustible Hookah Smoke, Electronic Hookah Aerosol, Clean Room Air, Exposure to Combustible Hookah Smoke, Exposure to Electronic Hookah Aerosol, Exposure to Clean Air


You can join if…

Open to people ages 21-49

  • 21-49 years old
  • Never a smoker: do not use any tobacco products or nicotine delivery systems, including cigarettes, cigars (traditional and filtered), cigarillos, hookah, smokeless tobacco (i.e., loose snus, moist snuff, dip, spit, or chewing tobacco), pipe tobacco, snus pouches, dissolvable tobacco or vaping.
  • no evidence of cardiopulmonary disease by history/physical
  • blood pressure (BP) < 140/90 mmHg
  • resting heart rate (HR) < 100 bpm
  • BMI >18 or < 30kg•m2
  • no prescription medication
  • No exposure to environmental tobacco smoke for at least one week prior to the study date.

You CAN'T join if...

  • exhaled carbon monoxide >6 ppm
  • (+) pregnancy test
  • other conditions deemed unsafe to participate, such as breastfeeding


  • University of California, Los Angeles accepting new patients
    Los Angeles California 90095-8361 United States

Lead Scientist at University of California Health


accepting new patients
Start Date
Completion Date
University of California, Los Angeles
Study Type
Expecting 12 study participants
Last Updated