Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at UCSD
Dates
study started
completion around

Description

Summary

The purpose of this study is to assess the objective response rate (ORR) of immunotherapy-based combination therapy and to assess the safety and tolerability of immunotherapy-based combination therapy.

Official Title

A Phase II, Open-label, Platform Study, to Evaluate Immunotherapy-based Combinations in Participants With Advanced Non-Small Cell Lung Cancer

Keywords

Advanced Non-Small Cell Lung Cancer, Domvanalimab, Zimberelimab, Quemliclustat, Anti-TIGIT antibody, Anti-PD-1 antibody, Lung Neoplasms, Non-Small-Cell Lung Carcinoma, Docetaxel, Platinum-Based Doublet, A1: Domvanalimab + Zimberelimab, A2: Domvanalimab + Zimberelimab, A3: Quemliclustat + Zimberelimab, B1: Quemliclustat + Zimberelimab + Platinum Doublet Chemotherapy, B2: Domvanalimab + Zimberelimab + Platinum Doublet Chemotherapy, B3: Domvanalimab + Quemliclustat + Zimberelimab + Platinum Doublet Chemotherapy, B4: Domvanalimab + Zimberelimab + Platinum Doublet Chemotherapy, B5: Domvanalimab + Zimberelimab + Platinum Doublet Chemotherapy, C1: Quemliclustat + Zimberelimab + Docetaxel, C2: Domvanalimab + Zimberelimab + Docetaxel

Eligibility

Locations

  • University of California San Diego (UCSD) accepting new patients
    La Jolla California 92093 United States
  • Medical Oncology Associated, PS (dba Summit Cancer Centers) accepting new patients
    Spokane Washington 99208 United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Gilead Sciences
ID
NCT05676931
Phase
Phase 2 research study
Study Type
Interventional
Participants
Expecting 400 study participants
Last Updated