Arthritis clinical trials at University of California Health
28 in progress, 15 open to eligible people
Ustekinumab or Guselkumab in Pediatric Participants With Active Juvenile Psoriatic Arthritis
open to eligible people ages 5-17
The purpose of this study is to evaluate the pharmacokinetics (PK), efficacy, safety and immunogenicity of ustekinumab and guselkumab in active juvenile psoriatic arthritis (jPsA).
at UCLA
Biofeedback Retention in Individuals With AKA
open to eligible people ages 18-70
More than two million Americans are currently living with a full or partial limb loss, and an additional 185,000 amputations occur each year. The majority of amputations occur in the lower limbs. There are many potential causes for amputation, but…
at UCSF
Bone Marrow Aspirate Concentrate (BMAC)Treatment for Knee Osteoarthritis
open to eligible people ages 45-75
The purpose of this study is to investigate the safety and effectiveness of bone marrow aspirate concentrate (BMAC) in patients with moderate to severe osteoarthritis of the knee. BMAC provides a rich source of mesenchymal stem cells (MSCs) and is a …
at UCSD
Omadacycline Randomized Treatment Given for Bone and Joint Infection
open to eligible people ages 18-85
The study design is a randomized, open-label, clinical trial of omadacycline vs Standard of Care (SOC) antibiotics for bone and join infection (BJI) treatment. Study participants will have their BJI regimen chosen by their treating physicians,…
at UCLA
Anti-inflammatory Diet in Rheumatoid Arthritis
open to eligible people ages 18 years and up
In a previous exploratory study, the investigators observed an effect on disease activity outcomes of anti-inflammatory diet. The investigators also observed change in microbiome and circulating metabolites. The current study will determine whether…
at UCSD
Elucidating Shared Mechanisms Contributing to NAFLD and PsA Disease Severity With Guselkumab Therapy
open to all eligible people
While many studies examine Nonalcoholic fatty liver disease (NAFLD), little is known about its progression to high-risk nonalcoholic steatohepatitis (NASH) in PsA patients. Shared disease mechanisms may explain the increased severity in PsA. This…
at UCSD
Nivolumab in Treating Patients With Autoimmune Disorders and Advanced, Metastatic, or Unresectable Cancer
open to eligible people ages 18 years and up
This phase Ib trial studies the side effects of nivolumab and to see how well it works in treating patients with autoimmune disorders and cancer that has spread to other places in the body or cannot removed by surgery. Immunotherapy with monoclonal…
at UC Davis
RA-PRO PRAGMATIC TRIAL
open to eligible people ages 18 years and up
The 2021 ACR RA treatment guideline, based on widely acknowledged low to moderate quality evidence, recommends switching to a non-tumor necrosis factor (TNFi) biologic (choose among existing medications, currently, rituximab, abatacept, tocilizumab, …
at UCLA
Rheumatoid Arthritis Shared Decision Making
open to eligible people ages 18 years and up
Shared decision making is the first overarching principle for the treat to target guidelines for rheumatoid arthritis (RA) and has been proposed as a potential mechanism to reduce health disparities, however there is little evidence to inform…
at UCSF
Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis
open to eligible people ages 18-70
This study will test the safety and effects of SBT777101 when given as a single dose to subjects with rheumatoid arthritis. It is the first study of this treatment being done in humans. Increasing dose levels will be given after the safety at lower…
at UCSF
Change in Disease Activity and Adverse Events of Oral Upadacitinib Compared to Subcutaneous Adalimumab in Adult Participants With Moderate to Severe Rheumatoid Arthritis
open to eligible people ages 18 years and up
Rheumatoid Arthritis (RA) is a chronic inflammatory disease causing pain, stiffness, swelling and loss of joint function. This study will assess how safe and effective upadacitinib is in treating RA when compared to adalimumab in adult participants…
at UCLA
Acthar in Rheumatoid Arthritis (RA) Related Flares
open to eligible people ages 18 years and up
This is a Rheumatoid Arthritis (RA) study. The purpose of this research study is to determine in RA flare, whether musculoskeletal ultrasound (MSUS) inflammatory scores and/or disease activity scores improve with Acthar treatment.
at UCLA
Defining the Molecular and Radiologic Phenotype of Progressive RA Interstitial Lung Disease
open to eligible people ages 18-90
A study to identify patients with Rheumatoid Arthritis - Associated Interstitial Lung Disease (RA-ILD) that are at the highest risk for progression. The goal of the investigators is to recruit a group of patients with RA-ILD and collect information…
at UCSF
Shoulder iD™ Primary Reversed Glenoid Outcomes Clinical Study
open to eligible people ages 18 years and up
The goal of the Shoulder iD™ Primary Reversed Glenoid Outcomes Clinical Study is to collect safety and performance data on the commercially available Shoulder iD™ Primary Reversed Glenoid device. The study will learn about standard device use in…
at UCSF
Stelara and Tremfya Pregnancy Exposure Registry OTIS Autoimmune Diseases in Pregnancy Project
open to eligible females
The purpose of the OTIS Autoimmune Diseases in Pregnancy Study is to monitor planned and unplanned pregnancies exposed to certain medications, to evaluate the possible teratogenic effect of these medications and to follow live born infants for one…
at UCSD
Adalimumab in JIA-associated Uveitis Stopping Trial
Sorry, in progress, not accepting new patients
The proposed study is a stratified, block-randomized, double-masked, controlled trial to determine the feasibility of discontinuing adalimumab treatment in patients with quiescent uveitis associated with juvenile idiopathic arthritis (JIA) or…
at UC Davis UCSF
CD40L Antagonism in Rheumatoid Arthritis (RA)
Sorry, in progress, not accepting new patients
The primary objective is to determine if the addition of a 12-week course of treatment with VIB4920 to TNFi treatment will result in improved clinical disease control in patients with RA who have had an inadequate response to a TNFi.
at UCSF
Insignia™ Hip Stem Outcomes Study
Sorry, in progress, not accepting new patients
The objective of this study is to evaluate the safety and effectiveness of the Insignia™ Hip Stem for global market access and post-market clinical follow-up up to 10 years postoperative.
at UCSF
Long Term Extension Study to Assess the Safety and Efficacy of Filgotinib in Adults With Rheumatoid Arthritis
Sorry, in progress, not accepting new patients
The primary objective of this study is to evaluate the long-term safety and tolerability of filgotinib in participants who have completed one of the parent studies of filgotinib in rheumatoid arthritis (RA).
at UCSD
Multidisciplinary Approach for Treat To Target In Rheumatoid Arthritis
Sorry, not yet accepting patients
This research will evaluate a multifaceted patient-centered intervention in a sample of socioeconomically disadvantaged Hispanic adults with rheumatoid arthritis (RA) that capitalizes on a partnership between the extended rheumatology healthcare…
at UCLA
Pharmacodynamics of GNSC-001 Intra-articular Injection for Knee Osteoarthritis
Sorry, in progress, not accepting new patients
The goal of this clinical study is to determine if a single injection of 1 or more dose levels of adeno-associated virus (AAV) gene therapy (GNSC-001) is safe and tolerated compared to placebo in participants with painful osteoarthritis (OA) of the…
at UCSD
Zimmer Trabecular Metal Total Ankle PMCF
Sorry, in progress, not accepting new patients
The primary objective of this study is to obtain implant survivorship and clinical outcome data for commercially available Zimmer Trabecular Metal Total Ankle implants used in primary or revision total ankle arthroplasty. The assessment will include …
at UC Davis
Zr-89 Cimzia PET Imaging Rheumatoid Arthritis
Sorry, currently not accepting new patients, but might later
This is a single center exploratory imaging study investigating the initial application of zirconium-89 Deferoxamine B Certolizumab pegol (89Zr-DFO-CZP) PET in patients with rheumatoid arthritis. Patients with active symptoms of RA or signs on…
at UCSF
Multi-Centre Study in Patients Undergoing Total Hip Arthroplasty With the Smith+Nephew CATALYSTEM™ Primary Hip System
Sorry, accepting new patients by invitation only
A Multi-Center Study in Patients Undergoing Total Hip Arthroplasty with the Smith+Nephew CATALYSTEM™ Primary Hip System. The purpose of the study is to assess safety and performance of the CATALYSTEM™ and to support product approval in global…
at UCSF
Apremilast Pregnancy Exposure Registry
Sorry, in progress, not accepting new patients
The purpose of the Apremilast Pregnancy Exposure Registry is to monitor planned and unplanned pregnancies exposed to apremilast and to evaluate the safety of this medication relative to specified pregnancy outcomes, and to evaluate potential effects …
at UCSD
Clinical and Molecular Characterization of Axial Psoriatic Arthritis (PsA), A Pilot Study
Sorry, accepting new patients by invitation only
Objectives: To identify a candidate set of biomarkers specific to AxPsA. Overview: Clinical and imaging characterization of PsA patients will be combined with extensive molecular assessment of both liquid and tissue compartments to identify…
at UCSD
OTIS Cimzia Pregnancy Registry
Sorry, in progress, not accepting new patients
The purpose of the OTIS Autoimmune Diseases in Pregnancy Study is to monitor planned and unplanned pregnancies exposed to certain medications, to evaluate the possible teratogenic effect of these medications and to follow live born infants for five…
at UCSD
Outcomes Study of the Trabecular Metal (TM) Reverse Shoulder System
Sorry, in progress, not accepting new patients
The objectives of this study are to obtain survival and outcome data on the Trabecular Metal Reverse Shoulder System when used in primary or revision reverse total shoulder arthroplasty.
at UCSF
Our lead scientists for Arthritis research studies include Drew Lansdown, MD Christina Chambers, PhD, MPH Veena K Ranganath, M.D., M.S. Monica Guma, MD, PhD Nisha Acharya Loren G. Miller, MD, MPH Richard Souza Robert Flavell George A Karpouzas, MD Kenneth Kalunian, MD Surbhi Singhal.
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