This study is not yet accepting patients

Personalized Accelerated Intermittent Theta Burst Stimulation for Post-Acute Suicidal Ideation

a study on Depression Suicidal Ideation

Summary

Eligibility
for people ages 15 years and up (full criteria)
Dates
study started
study ends around

Description

Summary

The goal of this clinical trial is to learn if a fast-acting brain stimulation treatment called transcranial magnetic stimulation (TMS) can help people with depression and suicidal thoughts. The treatment is non-invasive (does not involve surgery or medications), is given over 5 days, and uses brain imaging (MRI) to guide which part of the brain to target. This study tests whether this treatment is a helpful and practical option for patients who recently went to the hospital for suicidal thoughts and were sent home.

We want to see if:

  1. This treatment is feasible and acceptable to patients
  2. It can reduce depression and suicidal thoughts
  3. It can lower the chance of returning to the hospital
  4. It affects daily functioning (school, work, relationships)

All participants will undergo 5-days of TMS treatment within 1 week of leaving the hospital. All participants will complete MRI brain scans before and after treatment. They will return for check-ups after 1 week and 4 weeks.

Keywords

Major Depressive Disorder (MDD), Suicidal Ideation, TMS, MDD, transcranial magnetic stimulation, Major Depressive Disorder

Eligibility

You can join if…

Open to people ages 15 years and up

  • English speaking
  • Able to provide informed consent
  • ≥ 15 years old
  • Discharged within the past week from the ED for chief complaint of SI
  • MDD criteria per the Mini International Neuropsychiatric Interview (MINI)

You CAN'T join if...

  • Unable to consent (due to medical condition, psychosis, substance use, etc)
  • Active use of benzodiazepines or medications that would interfere with treatment with TMS as per PI discretion
  • Active substance use or severe substance use that in the opinion of the PI would interfere with study participation
  • Untreated, active psychosis
  • Female patient who is breastfeeding, pregnant or who is planning a pregnancy during the study
  • Dementia as documented in medical records
  • Bipolar disorder as determined by the MINI
  • Contraindications to receiving TMS and/or MRI as determined by screening questionnaires
  • Participation in any clinical study with exposure to any investigational treatment or product within the previous 30 days, or plan on concurrent participation in other studies.

Details

Status
not yet accepting patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, Davis
ID
NCT07025720
Study Type
Interventional
Participants
Expecting 25 study participants
Last Updated