The goal of this clinical trial is to learn whether home-based brain stimulation combined with virtual speech-language therapy can improve communication abilities in adults with logopenic variant primary progressive aphasia (lvPPA), a language disorder most often caused by Alzheimer's disease.
The main questions the study aims to answer are:
- Is combining remotely supervised transcranial direct current stimulation (tDCS) with virtual speech-language therapy feasible and acceptable for people with lvPPA?
- Does this combined treatment lead to improvements in communication compared to speech-language therapy with sham (placebo) stimulation?
- Do individual brain characteristics help predict who benefits most from this treatment?
Researchers will compare participants who receive active tDCS plus virtual speech-language therapy to participants who receive sham (placebo) tDCS plus virtual speech-language therapy to see if active brain stimulation enhances communication outcomes.
Participants will:
- Complete speech-language therapy sessions delivered by video visit.
- Receive either active or sham tDCS that is remotely supervised and completed at home.
- Complete language and cognitive testing before and after treatment.
- Undergo brain imaging and other assessments to help understand treatment response.
Investigating the Benefits of Remotely-Supervised Neuromodulation In Primary Progressive Aphasia
