Summary

Eligibility
for females ages 18 years and up (full criteria)
Location
at UCSF
Dates
study started
study ends around
Principal Investigator
by Effie Ioannidou, DDS, MDS (ucsf)Laura Jelliffe-Pawlowski, PhD (ucsf)
Headshot of Effie Ioannidou
Effie Ioannidou

Description

Summary

Many pregnant people don't get the dental care they need, even though it's safe and important. The CHEER Study offers free dental check-ups, cleanings, and supplies to help participants take care of their teeth and gums during pregnancy. The purpose of this research study is to compare two types of noninvasive oral health interventions to evaluate their effectiveness. We want to learn if one method is more effective in supporting oral health and improving pregnancy outcomes. There are two aims of this study:

Aim 1: To evaluate whether a structured oral health intervention reduces periodontal inflammation during pregnancy and postpartum in pregnant people with indicators of periodontal disease.

Aim 2: To assess whether a structured oral health intervention is associated with changes in oral health behaviors or birth outcomes in pregnant people with periodontal disease.

Official Title

Closing Health Equity Through Empowering Oral Health for Maternal Wellness

Details

The Closing Health Equity through Empowering Oral Health for Maternal Wellness (the CHEER Oral Health in Pregnancy Study) aims to address significant oral health disparities experienced by pregnant individuals, particularly those from low-income and minority communities in California.

Oral health is a critical yet often overlooked component of prenatal care. Existing evidence suggests that periodontal disease is associated with adverse pregnancy outcomes, such as preterm birth and low birth weight. However, many pregnant individuals in California do not receive adequate oral health services, especially those from historically marginalized communities. The CHEER Project aims to address this gap by implementing an intervention that is scalable, community-engaged, and grounded in evidence-based education.

This study will generate novel data on the impact of oral health education and behavior modification, delivered through accessible messaging and product use, on periodontal inflammation and disease status, and microbiome profiles. It will also explore potential downstream effects on perinatal outcomes. The study aligns with public health priorities to improve maternal wellness, health equity, and the integration of dental and medical care.

There are two study aims:

Aim 1: To evaluate whether a structured oral health intervention reduces periodontal inflammation during pregnancy and postpartum in pregnant people with indicators of periodontal disease.

Aim 2: To assess whether a structured oral health intervention is associated with changes in oral health behaviors or birth outcomes in pregnant people with periodontal disease.

Keywords

Gingivitis, Dental Health, Pregnancy, Pregnancy Outcomes, Randomized Controlled Trial, Periodontal Disease, Gum Disease, Periodontal Diseases, Gingival Diseases, Enhanced Care, Enhanced Care +

Eligibility

You can join if…

Open to females ages 18 years and up

  1. Pregnant individuals aged 18 years or older with indications of periodontal diseases (gingivitis or mild periodontitis, moderate to severe periodontitis)
  2. Less than 20 weeks pregnancy at time of enrollment
  3. Has dental insurance (Medi-Cal or private coverage)
  4. Willing and able to provide informed consent
  5. Planning to receive ongoing prenatal care at study-affiliated clinics
  6. Access to a mobile phone for receiving text messages

You CAN'T join if...

  1. Presence of systemic diseases or medical conditions that require antibiotic prophylaxis for dental procedures
  2. Current immunosuppressive therapy/use of anti-inflammatory medications
  3. Receipt of active periodontal treatment within the past 6 months
  4. Complete edentulism (no natural teeth)
  5. Unable to read and write English
  6. Less than 9th grade education
  7. Enrollment in another oral interventional study

Location

  • UCSF Dental Center
    San Francisco California 94143 United States

Lead Scientists at University of California Health

  • Effie Ioannidou, DDS, MDS (ucsf)
    Dr. Effie Ioannidou is a clinician scientist with training in Periodontology. Her research addresses clinical and translational questions on the anti-inflammatory effect of periodontal interventions in systemic health and chronic kidney disease. She has recently led a multicenter team of investigators to explore systemic antibiotic prescribing patterns in combination with periodontal therapy.
  • Laura Jelliffe-Pawlowski, PhD (ucsf)

Details

Status
not yet accepting patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT07377344
Study Type
Interventional
Participants
Expecting 160 study participants
Last Updated