for people ages 7-17 (full criteria)
Healthy Volunteers
healthy people welcome
study started
estimated completion
Principal Investigator
by Jane Kim (ucsd)



This study employs a cross-sectional design to profile the gut microbiome and urine metabolome in overweight/obese children with type 1 diabetes (T1D).


The investigators will obtain stool and urine samples from subjects aged 7-17 years in 4 groups: - Group 1: Obese or overweight children within 3 years of diagnosis of T1D - Group 2: Normal weight children within 3 years of diagnosis of T1D - Group 3: Obese or overweight children without T1D - Group 4: Normal weight children without T1D Type 1 diabetes will be defined according to American Diabetes Association criteria along with the presence of pancreatic autoantibodies (GAD65, ICA512, or insulin autoantibodies). Obese and overweight status will be defined by BMI >85th percentile for age and gender according to CDC criteria. All subjects will provide one-time stool and first morning urine sample. Overweight or obese subjects will additionally have a point of care blood glucose and hemoglobin A1c measurement to ensure that they do not have diabetes. The investigators will perform 16S rRNA sequencing of stool bacteria and mass spectrometry measurement of urine metabolites.


Obesity Overweight Type 1 Diabetes Mellitus Diabetes Mellitus Diabetes Mellitus, Type 1 Weight Gain No intervention


You can join if…

Open to people ages 7-17

  • Age 7 to 17 years
  • Diagnosis of diabetes will be defined by current American Diabetes Association criteria ° (fasting glucose > 126 mg/dl, 2 hour OGTT glucose > 200 mg/dl; random glucose > 200 with symptoms of hyperglycemia; or HbA1c > 6.5%)
  • Diabetes duration < 3 years
  • Presence of pancreatic autoimmunity (GAD65, ICA512, or insulin autoantibody positivity)
  • Adult caregiver willing to actively support study participation
  • Signed parental informed consent form and minor child informed assent form

You CAN'T join if...

  • Other significant organ system illness or condition (including psychiatric or developmental disorder) that, in the opinion of the investigator, would prevent participation


  • Rady Children's Hospital Endocrinology Department
    San Diego California 92123 United States

Lead Scientist at University of California Health


in progress, not accepting new patients
Start Date
Completion Date
University of California, San Diego
Study Type
Last Updated