for people ages 12-19 (full criteria)
study started
estimated completion
Principal Investigator
by Robert S Venick, MD (ucla)Emily Perito, MD (ucsf)
Photo of Emily Perito
Emily Perito



The study's aim is to test a tailored telemetric intervention to reduce rejection incidence by improving medication adherence in a group of adolescent liver transplant recipients identified as nonadherent by a marker (the Medication Level Variability Index, MLVI).


This is a prospective, multi-center, randomized controlled trial. The study will be conducted in transplant centers in the United States and Canada. Estimated final sample size of 140 after attrition. Pediatric adolescent and young adult (age at enrollment ≥12 and < 20) transplant recipients will be eligible for participation in the study. Eligible participants will be randomly assigned to intervention or control group. An interim analysis to evaluate efficacy will be performed. Missing data will not be imputed for secondary analyses.


Transplant Intervention Adherence Telemetric Intervention


You can join if…

Open to people ages 12-19

  • The patient is ≥ 12 and < 20 years of age at enrollment.
  • ≥2.5 years after last liver transplantation.
  • Guardian's consent, adolescent assent at enrollment.
  • The patient is prescribed tacrolimus.
  • The patient's MLVI (SD of tacrolimus) was > 2 when calculated by the site for a period of 2 years prior to the review date

You CAN'T join if...

  • The patient has had transplant of an organ other than liver.
  • The patient is currently listed for any organ transplantation.
  • The patient is expected to transition to another service (e.g., adult clinic, another
  • hospital) during the two years of the study.
  • Pregnant patients.
  • A temporary exclusion: the patient is not medically stable or was hospitalized for >48 consecutive hours in the past three months.
  • Site PI, study PI, or Medical Monitor determines that the patient should not be a candidate for the intervention due to factors that are not covered in the above criteria.


  • Mattel Children's Hospital UCLA accepting new patients
    Los Angeles California 90095 United States
  • Benioff Children's Hospital UCSF accepting new patients
    San Francisco California 94107 United States
  • Children's Hospital Los Angeles accepting new patients
    Los Angeles California 90027 United States

Lead Scientists at University of California Health

  • Robert S Venick, MD (ucla)
    Professor of Clinical , Pediatrics. Authored (or co-authored) 73 research publications.
  • Emily Perito, MD (ucsf)
    Associate Professor, Pediatrics. Authored (or co-authored) 83 research publications. Research interests: pediatric liver transplantation · long-term outcomes after liver transplantation · clinical research · chronic pancreatitis · pancreatic insufficiency · metabolic liver disease · non-alcoholic fatty liver disease · pediatric gastroenterology · epidemiology.


accepting new patients
Start Date
Completion Date
Icahn School of Medicine at Mount Sinai
Official Website of The iMALT Study
Study Type
Last Updated