Summary

Eligibility
for people ages 18-100 (full criteria)
Location
at UC Davis
Dates
study started
completion around
Principal Investigator
by Ryan M Martin (ucdavis)

Description

Summary

This study plans to evaluate the time course of inflammation in the brain after a moderate to severe traumatic brain injury using positron emission tomography (PET) brain imaging. Patients will undergo PET scans of the brain at two weeks and two months after injury to measure neuro-inflammation. The results of the PET scans will be analyzed and correlated with the risk of post-traumatic epilepsy.

Official Title

Imaging of Glial Activation and Risk for Post-Traumatic Epilepsy

Details

The development of post-traumatic epilepsy (PTE) is associated with neurobiological, cognitive, psychological, and social consequences that are far-reaching for the patient. Despite our keen awareness of this significant public health issue, little is known regarding the biological mechanisms leading to PTE. One plausible mechanism is that unchecked neuroinflammation, a process that occurs in animal and human models of both traumatic brain injury (TBI) and epilepsy, leads to altered synaptic transmission and neuronal excitability. However, the direct relationship between neuroinflammation and PTE has been difficult to ascertain from pre-clinical studies as they may not accurately reflect the human condition, as few animal models can induce the progression of PTE without a pharmacological enhancer and are predominately limited to studies of mild-to-moderate TBI given high animal mortality rates from more severe injuries. Measurements of neuroinflammation in human TBI and epilepsy has also proven difficult without invasive monitoring or post-mortem evaluations, and measurements of inflammatory mediators in blood or serum may not meaningfully reflect the extent of neuroinflammation.

Encouragingly though, positron emission tomography (PET) can be used to measure the degree of in vivo glial activation in the central nervous system through radiotracer binding of the translocator protein (TSPO), serving as a surrogate of neuroinflammation. Minimally expressed in the uninjured brain, TSPO binding is increased in a number of brain disorders associated with neuroinflammation, including Alzheimer's disease, ischemic stroke, recurrent head trauma in football, brain metastases, TBI, and epilepsy, and is expressed predominately by activated microglia, the main mediators of neuroinflammation. Currently, no pre-clinical or clinical study has analyzed the relationship between glia activation, as measured by TSPO PET, and the risk for developing PTE. Accordingly, we plan to use [18F]DPA-714 to characterize neuro-inflammation following moderate-to-severe TBI in order to better understand the temporal time course of neuro-inflammation following injury and its potential role in epileptogenesis.

Keywords

Epilepsy, Post-Traumatic, neuroinflammation, activated microglia, TSPO, Traumatic Brain Injury, TBI, Positron emission tomography, Epilepsy, Post-Traumatic Epilepsy, [18F]DPA-714 Positron Emission Tomography Scan, Moderate to Severe Traumatic Brain Injury

Eligibility

You can join if…

Open to people ages 18-100

  • Acute Traumatic Brain Injury (TBI)
  • Age 18-100 are eligible
  • Glasgow Coma Scale (GCS) 3-13 without continuous sedation at time of enrollment
  • Ability to enroll within 72 hours of injury
  • Hemorrhagic contusional injuries to frontal and/or temporal lobes.
  • Polytrauma including long bone fractures, blunt trauma, abdominal trauma or similar will be allowed
  • Penetrating TBI if continuous electroencephalography (cEEG) is feasible and survival for 2 years is feasible, recognizing that MRI may not be feasible with some forms of penetrating trauma

You CAN'T join if...

  • Low-affinity TSPO binding profile
  • Ages 17 years or younger
  • Patients with diffuse axonal injury in the absence of hemorrhagic contusions or skull fracture, and isolated epidural hemorrhages that improve after evacuation
  • No planned continuous EEG monitoring during injury day 1-7
  • Inability to undergo MRI at 14 days (± 4 days) due to bullet, metal implant, or pacemaker
  • Pregnancy
  • Pre-existing Neurodegenerative Disorders
  • Pre-existing epilepsy/seizure disorder
  • Pre-existing dementia
  • Isolated anoxic brain injury
  • Incarceration present or pending
  • Devastating cervical spine injury

Location

  • University of California, Davis accepting new patients
    Sacramento California 95817 United States

Lead Scientist at University of California Health

  • Ryan M Martin (ucdavis)
    Associate Professor, Med: Neurological Surgery, School of Medicine. Authored (or co-authored) 8 research publications

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, Davis
ID
NCT03999164
Phase
Phase 1 Epilepsy Research Study
Study Type
Interventional
Participants
Expecting 30 study participants
Last Updated