COVID-19 clinical trials at University of California Health
47 in progress, 22 open to eligible people
Pilot rTMS Trial for Neuropsychiatric Symptoms of Long-COVID
open to eligible people ages 18 years and up
This is a pilot randomized trial of rTMS for symptoms of fatigue and brain fog, and other neuropsychiatric symptoms of Long-COVID (Post-COVID, post-acute sequelae of COVID-19 infection, PASC). Twenty participants diagnosed with Long-COVID and…
at UCLA
Immunosuppression Adjustment on COVID-19 Vaccination Response in Kidney Transplant Recipients
open to eligible people ages 18 years and up
Immunocompromised individuals, such as solid organ transplant (SOT) recipients are at high risk of COVID-19 associated complications and mortality. Retrospective studies so far have shown that a majority of SOT recipients did not develop appreciable …
at UC Davis
I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients
open to eligible people ages 18 years and up
The goal of this project is to rapidly screen promising agents, in the setting of an adaptive platform trial, for treatment of critically ill COVID-19 patients. In this phase 2 platform design, agents will be identified with a signal suggesting a…
at UC Davis UC Irvine UCSF
CArdiac REhabilitation for Building Exertional heArt Rate for Chronotropic Incompetence in Long COVID-19
open to eligible people ages 18 years and up
The goal of this proof-of-concept clinical trial is to determine whether cardiac rehabilitation improves exercise capacity and chronotropic (heart rate) response to exercise among people with Long COVID. The study will include individuals with…
at UCSF
Community-engaged Optimization of COVID-19 Rapid Evaluation and TEsting Experiences
open to all eligible people
Throughout the Coronavirus disease (COVID-19) pandemic, rates of COVID-19 have been persistently high in San Diego County's central and southern communities near the United States/Mexico border. These regions predominantly house Latino residents,…
at UCSD
Coronavirus Disease 2019 (Covid-19) Impact on Alcohol-related Liver Disease Patient Outcomes, Care and Alcohol Use
open to eligible people ages 18 years and up
The study consists of a randomized controlled trial evaluating the efficacy and feasibility of a stepped alcohol treatment using telemedicine on unhealthy alcohol use in patients with chronic liver disease receiving care in hepatology practices at…
at UCSF
Exercise in Child Health
open to eligible people ages 10-17
This study is a cooperative investigation funded by the NIH. The project is a collaboration among three major NIH Clinical Translational Science Awardees: 1) UCI (lead site with its affiliate CHOC), 2) Northwestern University (with its affiliate…
at UC Irvine
Imaging Immune Activation in COVID-19
open to eligible people ages 18 years and up
This is a single center, single arm exploratory imaging study involving up to two intravenous microdoses of [18F]F-AraG (the second tracer dose is optional) followed by whole-body PET-CT imaging in participants with convalescent COVID-19. Up to 80…
at UCSF
DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study
“Volunteer for research and contribute to discoveries that may improve health care for you, your family, and your community!”
open to all eligible people
This study will seek to enroll immunocompromised patients with Lower Tract parainfluenza infection. It also contains a sub-study to enroll patients with severe COVID-19.
at UC Davis UCLA UCSD
Long Haul COVID Rehabilitation & Recovery Research Program
open to eligible people ages 18-90
The purpose of the study is to assess the physiologic, immunologic, and mental health effects of a rehabilitation program on patients with Long Haul COVID (LHC).
at UCLA
EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID
open to eligible people ages 18 years and up
The overarching goal of this study is to determine if baricitinib, as compared to placebo, will improve neurocognitive function, along with measures of physical function, quality of life, post-exertional malaise, effect of breathlessness on daily…
at UCSF
RECOVER-AUTONOMIC Platform Protocol
open to eligible people ages 18 years and up
This study is a platform protocol designed to be flexible so that it is suitable for a wide range of settings within health care systems and in community settings where it can be integrated into COVID-19 programs and subsequent treatment plans. This …
at UCSD
RECOVER-ENERGIZE Platform Protocol
open to eligible people ages 18 years and up
This is a platform protocol designed to be flexible so that it is suitable for a range of interventions and settings within diverse health care systems and community settings with incorporation into clinical COVID-19 management programs and…
at UCLA
RECOVER-SLEEP: Platform Protocol
open to eligible people ages 18 years and up
The platform protocol is designed to be flexible so that it is suitable for a range of study settings and intervention types. Therefore, the platform protocol provides a general protocol structure that can be shared by multiple interventions and…
at UCSF
Strategies and Treatments for Respiratory Infections & Viral Emergencies (STRIVE): Shionogi Protease Inhibitor (Ensitrelvir)
open to eligible people ages 18 years and up
Treatments are needed to improve outcomes among patients hospitalized for COVID-19, including direct-acting antiviral (DAA) agents to mitigate the pathology driven by ongoing viral replication. This trial will evaluate S-217622 (ensitrelvir), an…
at UC Davis UCLA UCSD UCSF
Strategies and Treatments for Respiratory Infections &Amp; Viral Emergencies (STRIVE): Immune Modulation Strategy Trial
open to eligible people ages 18 years and up
COVID-19 can trigger a dysregulated immune response, and previous studies have shown that immune modulation can improve outcomes in hospitalized patients. This trial is designed to determine whether intensification of immune modulation early in the…
at UC Davis UCLA UCSD UCSF
COVID-19 Outcome Prediction Algorithm
open to eligible people ages 18 years and up
Severe acute respiratory syndrome coronavirus 2-mediated coronavirus disease (COVID-19) is an evolutionarily unprecedented natural experiment that causes major changes to the host immune system. We propose to develop a test that accurately predicts…
at UCLA
KIDney Injury in Times of COVID-19 (KIDCOV)
open to eligible people ages 18 years and up
There is an unmet need to evaluate the impact of sub-clinical/mild COVID19 disease in the outpatient setting on prevalent and incident renal injury, as this data is currently unavailable. To capture the diversity of race/ethnic risk and COVID19…
at UCSF
Long-term Impact of Infection With Novel Coronavirus (COVID-19)
open to eligible people ages 18-100
LIINC is a study of volunteers who were previously infected with SARS-CoV-2 (also known as novel coronavirus or COVID-19) who have recovered from acute infection. The study is designed to provide a specimen bank of samples with carefully…
at UCSF
Neural and Cognitive Consequences of COVID-19 Survival
open to eligible people ages 18-70
The novel coronavirus SARS-CoV-2 infection, COVID, continues to rage throughout the world with 115,000,000 confirmed cases and over 2,500,000 deaths (as of Mar 3, 2021). This translates to millions of people surviving COVID19 infection. While the…
at UCSF
Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
open to eligible people ages 0-20
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The…
at UCLA
Researchers At UC San Diego Are Learning About the Benefits of Human Milk and How It Influences Infant and Child Health
open to eligible females ages 18 years and up
The purpose of the UCSD Human Milk Biorepository is to establish and maintain a repository of breast milk samples that can be used to learn more about how breast milk influences infant and child health.
at UCSD
T Follicular Helper (TFH)-Targeting Genetic Vaccine Strategy Designed to Induce Broad, Durable Immune Responses
Sorry, not yet accepting patients
The goal of this clinical trial is to test two investigational COVID-19 booster vaccines, called CoTend-s3BXBB and CoTend-BXBB, in healthy volunteers ages 40-64. The CoTend-s3BXBB vaccine includes a component called "s3", which was designed to…
at UC Davis UCLA UCSF
EB05 + SOC Vs. Placebo + SOC in Adult Hospitalized Patients with COVID-19
Sorry, currently not accepting new patients, but might later
COVID-19 patients who develop severe disease often develop acute respiratory distress syndrome (ARDS) as a result of a dysregulated immune response. This in turn stimulates a pro-inflammatory cascade ("cytokine storm") as well as emergency…
at UCSF
Positive Emotions With Long COVID-19
Sorry, in progress, not accepting new patients
This study is testing a new brief mindfulness practice for people suffering from long COVID-19 symptoms. People suffering from long COVID are particularly vulnerable to negative emotions, as they must also cope with the long-term uncertainty of…
at UC Davis
PET/CT Imaging in COVID-19 Patients
Sorry, accepting new patients by invitation only
This is a PET/CT study using the 18F-αvβ6-binding-peptide.The goal of this study is to evaluate this peptide in patients after infection with SARS CoV2.
at UC Davis
Anti-SARS-CoV-2 Monoclonal Antibodies for Long COVID (COVID-19)
Sorry, in progress, not accepting new patients
Persistent viral infection with viral reservoirs and detection of circulating spike protein after the initial acute illness is one potential pathogenic mechanism for Long COVID. This mechanism may be able to be targeted by SARS-CoV-2 monoclonal…
at UCSF
Chinese Herbal Formula for COVID-19
Sorry, in progress, not accepting new patients
This is a multi-center, randomized, double-blind, placebo-controlled clinical trial to evaluate a 21-herb formula named modified Qing Fei Pai Du Tang (mQFPD) to treat COVID-19-positive outpatients with mild-to-moderate symptoms assigned to…
at UCLA UCSD
Cognitive Rehabilitation Therapy for COVID-19
Sorry, accepting new patients by invitation only
Cognitive dysfunction, psychiatric symptoms, functional impairment, and disability following COVID-19 negatively impact Veterans' community functioning and quality of life, contribute to significant human suffering, and are costly to VHA.…
at UCSD
COVID Protection After Transplant - Sanofi GSK (CPAT-SG) Study
Sorry, in progress, not accepting new patients
An open label, non-randomized pilot study in kidney transplant recipients who received a completed primary series and bivalent booster of mRNA based COVID-19 vaccine and have =<2500 U/mL SARS-CoV-2 S antibody concentration using the Roche Elecsys(R) …
at UCSD UCSF
IgPro20 in Post-COVID-19 POTS
Sorry, not currently recruiting here
This is a prospective, phase 3, multicenter, double-blind, randomized placebo-controlled study to investigate the efficacy, safety, and pharmacokinetics (PK) of repeat doses of IgPro20 in participants with post SARS-CoV-2 infection 2019 postural…
at UC Irvine UCSD
Ensitrelvir for Viral Persistence and Inflammation in People Experiencing Long COVID
Sorry, in progress, not accepting new patients
Persistent viral infection with viral reservoirs and detection of circulating spike protein after the initial acute illness is one potential pathogenic mechanism for Long COVID. This mechanism may be susceptible to antiviral therapy that blocks…
at UCSF
EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease
Sorry, not currently recruiting here
The purpose of this clinical trial is to learn about the safety, pharmacokinetics (pharmacokinetics helps us understand how the drug is changed and eliminated from your body after you take it), and efficacy (how well a study treatment works in the…
at UCLA
Getting Asian Americans INFORMED to Facilitate COVID-19 Testing and Vaccination
Sorry, in progress, not accepting new patients
This study develops and evaluates the "INdividual and Family-Oriented Responsive Messaging EDucation" (INFORMED) intervention in increasing knowledge about COVID-19 testing and decreasing decisional conflicts of getting tested for COVID-19. A 2-arm…
at UC Davis UCSF
Mushroom-based Product for COVID-19
Sorry, in progress, not accepting new patients
This is a multi-center, randomized, double-blind, placebo-controlled clinical trial to evaluate two polypore mushrooms, Fomitopsis officinalis and Trametes versicolor (FoTv), to treat COVID-19-positive outpatients with mild-to-moderate symptoms…
at UC Irvine UCLA UCSD
RCT of Mushroom Based Natural Product to Enhance Immune Response to COVID-19 Vaccination
Sorry, in progress, not accepting new patients
This is a randomized, double-blind, placebo-controlled clinical trial to evaluate the effect of two polypore mushrooms, Fomitopsis officinalis and Trametes versicolor (FoTv), for use as an adjunct to vaccination for COVID-19 in a general population…
at UCSD
Working Towards Empowered Community-driven Approaches to Increase Vaccination and Preventive Care Engagement
Sorry, accepting new patients by invitation only
This study will optimize, implement, and test the impact of our multicomponent health program that includes three primary implementation strategies (Cultural Weavers and co-creation, mHealth strategies using culturally meaningful text and voice…
at UCSD
Provide at Home Subcutaneous Administration of Pertuzumab and Trastuzumab Fixed-Dose Combination (PH FDC SC) for Patients With HER2-Positive Breast Cancer During the COVID-19 Pandemic
Sorry, not accepting new patients
This single arm, multicenter study provides the pertuzumab and trastuzumab fixed-dose combination formulation for subcutaneous injection (PH FDC SC) administered at home by a home health nursing provider for patients with human epidermal growth…
at UCSF
ASCO Survey on COVID-19 in Oncology (ASCO) Registry
Sorry, in progress, not accepting new patients
The American Society of Clinical Oncology (ASCO) Survey on Coronavirus 2019 (COVID-19) in Oncology Registry (ASCO Registry) aims to help the cancer community learn more about the patterns of symptoms and severity of COVID-19 among patients with…
at UCSF
Pregnancy In the CoRonavirus (COVID-19) pandEmic
Sorry, in progress, not accepting new patients
Prospective nationwide cohort study of pregnant women enrolled early in gestation and followed for Covid-19 exposure and infection, with follow up of obstetrical outcomes and infant development through the first year of life.
at UCSF
COVID-19 Recovered Volunteer Research Participant Pool Registry
Sorry, in progress, not accepting new patients
This is a prospective observational registry of COVID-19 recovered patients who are no longer symptomatic. This Registry is intended to serve as a pool of individuals that can participate in studies associated with serological testing,…
at UCLA
Immunologic Response Following COVID-19 Vaccination in Children, Adolescents, and Young Adults With Cancer
Sorry, in progress, not accepting new patients
This study evaluates immunologic response following COVID-19 vaccination in children, adolescents, and young adults with cancer. Vaccines work by stimulating the body's immune cells to respond against a specific disease. The immune response produces …
at UCSF
Treatment Protocol: Remdesivir (RDV; GS-5734) for the Treatment of SARS-CoV2 (CoV) Infection (COVID-19)
Sorry, not accepting new patients
The primary objective of this study is to provide expanded access of remdesivir (RDV) for the treatment of severe acute respiratory syndrome coronavirus (SARS-CoV2) infection.
at UCSF
Innovative Support for Patients with SARS-COV2 Infections (COVID-19) Registry (INSPIRE)
Sorry, in progress, not accepting new patients
The Innovative Support for Patients with SARS COV-2 Infections Registry (INSPIRE) study is a CDC-funded COVID-19 project to understand the long-term health outcomes in recently tested adults, both negative and positive, who have suspected COVID…
at UCLA UCSF
NCI COVID-19 in Cancer Patients, NCCAPS Study
Sorry, in progress, not accepting new patients
This study collects blood samples, medical information, and medical images from patients who are being treated for cancer and have a positive test for SARS CoV-2, the new coronavirus that causes the disease called COVID-19. Collecting blood samples, …
at UC Davis UC Irvine UCLA UCSD UCSF
Long-term Impact of COVID on Children and Families
Sorry, in progress, not accepting new patients
This is a combined retrospective and prospective, longitudinal, observational meta-cohort of individuals age 0-25 years who will enter the cohort with and without SARS-CoV-2 infection at varying stages before and after infection. Individuals with…
at UCSD UCSF
Long-term Impact of COVID-19 in Adults (RECOVER)
Sorry, in progress, not accepting new patients
This is a combined retrospective and prospective, longitudinal, observational meta-cohort of individuals who will enter the cohort with and without SARS-CoV-2 infection and at varying stages before and after infection. Individuals with and without…
at UCSF
Our lead scientists for COVID-19 research studies include Helen Lavretsky, MD, MS Steven Deeks, MD Pam Taub, MD Michael J Peluso, MD Heather Huddleston, MD Aric Prather Arash Naeim, MD, PhD Nicole Stadnick Minnie Sarwal, M.D., Ph.D. Andrew Shubov, MD Javier E Lopez, MD Laura Esserman, MD Timothy Henrich, MD Mandana Khalili, M.D. Louise Laurent, MD/PhD George W. Lim, MD William W Stringer, MD Jaime Deville Janice Y Tsoh, PhD Mario C. Deng, MD Julie L. Sutcliffe, Ph.D Stuart Cohen, MD Aileen X Wang, MD Kara Chew, MD, MS Dan Cooper Judith M Ford, PhD Kathleen D Liu, MD.
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