Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at UC Irvine UCSD
Dates
study started
estimated completion
Principal Investigator
by Susan O'Brien (uci)Michael Choi (ucsd)

Description

Summary

This study evaluates the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). CLL and SLL are types of blood cancer that begin in cells of the immune system. CLL/SLL and the medications used to treat these conditions may change the way vaccines work in a patient's body. The purpose of this study is to find out if patients with CLL/SLL make antibodies, or have an immune response, to the SARS-CoV-2 vaccines. Information gained from this study may help researchers better understand how effective the vaccines work in preventing COVID-19 (coronavirus disease 2019) in patients with CLL and SLL.

Official Title

Multicenter Evaluation of SARS-CoV-2 Vaccines in Patients With CLL/SLL

Details

OUTLINE: For patients who have not been vaccinated at the time of enrollment, they will undergo collection of blood samples prior to the first vaccine dose, just before the second vaccine dose, and then at 1, 6, and 12 months after the second vaccine dose. Patients' medical records are also reviewed. For patients enrolled after vaccination, they will undergo collection of blood samples at 1-4, 6, and 12 months after completing the vaccination series. After completion of study, patients are followed up every 6 months for 2 years.

Keywords

Chronic Lymphocytic Leukemia Small Lymphocytic Lymphoma Lymphoma Leukemia Leukemia, Lymphoid Leukemia, Lymphocytic, Chronic, B-Cell Biospecimen Collection Electronic Health Record Review

Eligibility

You can join if…

Open to people ages 18 years and up

  • Age >= 18 years
  • A diagnosis of chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL)

You CAN'T join if...

  • Any known history of prior SARS-CoV-2/COVID19 infection

Locations

  • UC Irvine Health/Chao Family Comprehensive Cancer Center accepting new patients
    Orange California 92868 United States
  • University of California San Diego not yet accepting patients
    San Diego California 92103 United States

Lead Scientists at University of California Health

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of Washington
ID
NCT04852822
Study Type
Observational
Last Updated