Summary

Eligibility
for people ages 18-100 (full criteria)
Location
at UCLA
Dates
study started
estimated completion
Principal Investigator
by Noah Kojima (ucla)

Description

Summary

The purpose of this protocol is to investigate the ability of pre-existing immunity by natural infection or vaccination to prevent infections by emerging SARS-CoV-2 variants.

Details

Several variants of the SARS-CoV-2 virus were identified in 2020 including the United Kingdom variant (known as 20I/501Y.V1, VOC 202012/01, or B.1.1.7), South Africa variant (known as 20H/501Y.V2 or B.1.35), and Brazil variant (known as P.1), with more variants still being discovered. There is concern that these variants, due to mutations in spike protein and receptor-binding domain of the spike protein, can be more infectious, lethal, and potentially escape the immune responses from vaccination or prior infection. Research is needed to understand the risks associated with currently known variants of SARS-CoV-2 as well as investigate if there is potential for new mutations to form that would allow SARS-CoV-2 variants to partially or entirely escape the immune mechanisms developed from vaccination and/or prior infection from the wild-type strain of SARS-CoV-2.

Keywords

COVID-19; Immunity COVID-19 No intervention

Eligibility

You can join if…

Open to people ages 18-100

  • People who have been fully vaccinated for COVID-19 2-12 weeks prior to enrollment or individuals <3 months post-COVID-19 infection.
  • Collection of samples for blood samples will be done only from healthy, nonpregnant adults who weigh at least 110 pounds.
  • Participants must be able to provide informed consent.

You CAN'T join if...

-Subjects considered vulnerable including children, pregnant women, nursing home residents, or other institutionalized persons, fetuses, prisoners, and persons without decisional capacity.

Location

  • Curative accepting new patients
    San Dimas California 91773 United States

Lead Scientist at University of California Health

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, Los Angeles
ID
NCT05171803
Study Type
Observational
Last Updated