for people ages 18-80 (full criteria)
at UC Davis
study started
completion around
Principal Investigator
by Oyebimpe O Adesina, MD, MS (ucdavis)



A prospective study to determine how low bone mineral density and/or vertebral compression fractures associate with pain in adults with sickle cell disease

Official Title

Association Between Low Bone Density, Vertebral Fractures, and Pain in Sickle Cell Disease


The investigators hypothesize that adults with sickle cell disease (SCD) and low bone density and/or vertebral compression fractures on a dual X-ray absorptiometry (DXA) scan (adjusted for age, sex, SCD genotype, relevant labs, presence of osteonecrosis, and SCD-modifying therapies) will report more severe pain than those with normal bone density or no vertebral fractures. The Adult Sickle Cell Quality of Life Measurement System (ASCQ-Me) is a validated patient-reported outcome measure of physical, mental, and social health in adults with SCD. This cross-sectional observational study involves obtaining a baseline DXA scan, vertebral fracture analysis (VFA) and pain assessment using ASCQ-Me pain impact scores. The investigators plan to recruit 50 adults with SCD followed at University of California Davis Medical Center between Nov 2022- Oct 2023, and anticipate enrolling 4-6 adults with SCD per month. The study endpoints are listed below:

  • To determine the association between bone density Z-scores and ASCQ-Me pain impact scores in a prospective cohort of adults with SCD
  • To study the association between Spine Deformity Index scores (SDI, a proxy for vertebral fracture analysis) and ASCQ-Me pain impact scores in a prospective cohort of adults with SCD
  • To assess the correlation between baseline hematological and biochemical laboratory parameters (including bone biomarkers), bone density, and/or vertebral fractures in a prospective cohort of adults with SCD

The investigators' goal is to complete primary data analysis by Mar 2024. As an exploratory endpoint, 1cc of serum and 5cc of urine will be collected from each study participant once (at baseline), after an overnight fast, for bone biomarker analyses.


Sickle Cell Disease, Sickle Cell Anemia, Low Bone Density, Osteoporosis, Osteopenia, Vertebral Fracture, Vertebral Compression, Osteonecrosis, Ischemic Necrosis, Avascular Necrosis, low bone mass, Metabolic Bone Diseases, Necrosis, Spinal Fractures, Dual-energy X-ray absorptiometry, Vertebral fracture analysis


You can join if…

Open to people ages 18-80

  • Age 18-80 years with SCD (any genotype, confirmed by hemoglobin electrophoresis or high performance liquid chromatography)
  • Ability to provide written informed consent
  • Ability to lay on a DXA scanner
  • Negative urine pregnancy test for women of childbearing potential at study entry

You CAN'T join if...

  • Pregnant women
  • Adults unable to consent
  • Individuals who are not yet adults (infants, children, teenagers)
  • Prisoners
  • Hospitalizations (any cause) within 2 weeks of study entry


  • UC Davis Comprehensive Cancer Center
    Sacramento California 95817 United States

Lead Scientist at University of California Health

  • Oyebimpe O Adesina, MD, MS (ucdavis)
    Assistant Professor, Hematology and Oncology, School of Medicine. Authored (or co-authored) 10 research publications


in progress, not accepting new patients
Start Date
Completion Date
University of California, Davis
Study Type
About 53 people participating
Last Updated