This study is in progress, not accepting new patients

EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction

a study on Cardiovascular Disease Heart Attack Stroke Coronary Revascularization ST-Elevation Myocardial Infarction

Summary

Eligibility
for people ages 18-99 (full criteria)
Location
at UC Irvine UCLA
Dates
study started
study ends around

Description

Summary

The primary objective of this study is to evaluate the effectiveness of early treatment with evolocumab plus routine lipid management vs routine lipid management alone when administered in the acute setting to reduce myocardial infarction, ischemic stroke, arterial revascularization, and all-cause death in subjects hospitalized for an acute myocardial infarction (non-ST-segment elevation myocardial infarction [NSTEMI] and ST-segment elevation myocardial infarction [STEMI]).

Official Title

EVOLVE-MI: A Pragmatic Randomized Multicenter Trial of EVOLocumab Administered Very Early to Reduce the Risk of Cardiovascular Events in Patients Hospitalized With Acute Myocardial Infarction

Keywords

Cardiovascular Disease, Myocardial Infarction, Stroke, Coronary Revascularization, Acute Myocardial Infarction, Evolocumab, STEMI, NSTEMI, Heart Attack, Pragmatic, Cardiovascular Diseases, ST Elevation Myocardial Infarction, Non-ST Elevated Myocardial Infarction, Routine Lipid Management, Evolocumab + Routine Lipid Management

Eligibility

You can join if…

Open to people ages 18-99

  • Age greater than or equal to 18 years
  • Hospitalized for primary reason of NSTEMI or STEMI due to presumed atherosclerotic disease

You CAN'T join if...

  • Participants requiring invasive hemodynamic and/or vasopressor/inotropic support at the time of screening
  • Participants with elevated biomarkers of myocardial injury due to secondary/nonatherosclerotic etiology (eg, sepsis, atrial fibrillation, vasospasm, decompensated heart failure, uncontrolled hypertension, stress induced cardiomyopathy)

Locations

  • University of California Los Angeles
    Los Angeles 5368361 California 5332921 90095 United States
  • University of California-Irvine
    Orange 5379513 California 5332921 92868 United States
  • VA Greater Los Angeles Healthcare System
    Los Angeles 5368361 California 5332921 90073 United States
  • John Muir Health and Cardiovascular Institute
    Concord 5339111 California 5332921 94520 United States

Details

Status
in progress, not accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Amgen
Links
AmgenTrials clinical trials website
ID
NCT05284747
Phase
Phase 4 research study
Study Type
Interventional
Participants
About 6019 people participating
Last Updated