Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at UCLA
Dates
study started
completion around

Description

Summary

This is a Phase 2 randomized, double-blind, placebo-controlled, multicenter study evaluating the efficacy and safety of AK117 or placebo, combined with azacitidine in patients with newly diagnosed higher-risk myelodysplastic syndromes (HR-MDS).

Official Title

A Randomized, Double-blind, Placebo-controlled, Multicenter Phase 2 Study of AK117/Placebo in Combination With Azacitidine in Patients With Newly Diagnosed Higher-risk Myelodysplastic Syndromes

Keywords

Higher-risk Myelodysplastic Syndromes, Preleukemia, Myelodysplastic Syndromes, Syndrome, Azacitidine

Eligibility

You can join if…

Open to people ages 18 years and up

  • Age ≥ 18 years old at the time of enrolment.
  • Eastern Cooperative Oncology Group (ECOG) performance status score of 0 to 2.
  • Expected life expectancy ≥ 3 months.
  • Newly diagnosed HR-MDS, according to the 2016 World Health Organization (WHO) classification with the presence of < 20% blasts in bone marrow or peripheral blood; Overall IPSS-R score ≥ 3.5.
  • Ability to undergo the study-required bone marrow sample collection procedures.
  • Suitable venous access for the study-required blood sampling (i.e., including PK and immunogenicity).
  • Female patients of childbearing age must have negative serum pregnancy test results before randomization or per region-specific guidance documented in the informed consent and a negative urine pregnancy test on the day of first dose prior to dosing.
  • Female patients of childbearing potential having sex with an unsterilized male partner must agree to use a highly effective method of contraception from the beginning of screening until 180 days after the last dose of the study treatment.
  • Unsterilized male patients having sex with a female partner of childbearing potential must agree to use an effective method of contraception from the beginning of screening until 180 days after the last dose of study treatment.

You CAN'T join if...

  • MDS evolving from a pre-existing myeloproliferative neoplasm (MPN), myelodysplastic/myeloproliferative neoplasms (MDS/MPN).
  • Prior treatment with Cluster of Differentiation (CD) 47 or Signal-regulatory protein alpha (SIRPα)-targeting agents.
  • Concurrently participating in another interventional clinical study, unless it is an observational (non-interventional) clinical study or during the follow-up period of an interventional study.
  • Patients who previously diagnosed with another malignancy and have any evidence of residual disease.
  • Known allergy to any component of any study drug; known history of severe hypersensitivity to other monoclonal antibodies.
  • Patients with any psychiatric or social factor which the investigator deems may interfere with the patient's ability to comply with the requirements of the study.
  • Patients with current hypertension with systolic blood pressure ≥ 160 mmHg or diastolic blood pressure ≥ 100 mmHg after oral antihypertensive therapy.
  • Patients with known cardiopulmonary disease defined as unstable angina, clinically significant arrhythmia, congestive heart failure (New York Heart Association Class III or IV), decompensated cirrhosis, nephrotic syndrome, uncontrolled metabolic disorders.
  • Patients who are breastfeeding or plans to breastfeed during the study.
  • Other conditions where the investigator considers the patient inappropriate for enrollment.

Locations

  • UCLA Ronald Reagan Medical Center accepting new patients
    Los Angeles California 90095 United States
  • Rocky Mountain Cancer Centers accepting new patients
    Aurora Colorado 80012 United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Akeso
ID
NCT06196203
Phase
Phase 2 Myelodysplastic Syndrome Research Study
Study Type
Interventional
Participants
Expecting 90 study participants
Last Updated