Summary

Eligibility
for people ages 18-65 (full criteria)
Location
at UCSD
Dates
study started
completion around
Principal Investigator
by Jyoti Mishra, PhD (ucsd)
Headshot of Jyoti Mishra
Jyoti Mishra

Description

Summary

Repetitive Transcranial Magnetic stimulation (rTMS) is an FDA-approved therapy for treatment resistant depression (TRD) that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex (DLPFC) brain region. But studies of rTMS alone show remission rates of ~30%. Additionally, rTMS has not been shown to improve cognitive functioning that may be an independent factor predicting treatment success. This study will develop a novel multimodal treatment, which combines intermittent theta burst stimulation (iTBS) - a type of rTMS with digital mindfulness training to engage brain plasticity, enhance cognition and alleviate depression symptoms in individuals with TRD.

Details

This study aims to develop a novel multimodal treatment for treatment resistant depression (TRD), which combines intermittent theta burst stimulation (iTBS), a type of FDA-approved rTMS protocol, with digital mindfulness training. We propose that this multimodal treatment will suppress posterior Default Mode Network (pDMN) brain activity as measured with electroencephalography (primary outcome and neural target), as well as enhance cognition and alleviate depression symptoms in patients with TRD. The study will determine the optimal dose required for neural target engagement by the multimodal iTBS + digital mindfulness training relative to an active control training combined with iTBS.

Keywords

Depression, Treatment Resistant Depression, Major Depressive Disorder, Depressive Disorder, rTMS, mindfulness, Treatment-Resistant Depressive Disorder, Medi-TBS, Medi1-TBS, Medi2-TBS, Medi3-TBS

Eligibility

Location

  • University of California San Diego accepting new patients
    La Jolla California 92093 United States

Lead Scientist at University of California Health

  • Jyoti Mishra, PhD (ucsd)
    Dr. Mishra is trained in the computational, cognitive and translational neurosciences. She is the founder of the Neural Engineering & Translation Labs (NEATLabs) at UCSD. Her lab innovates digital technologies for scalable brain health mapping, monitoring and precision therapeutics.

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Diego
ID
NCT06399406
Phase
Phase 2 research study
Study Type
Interventional
Participants
Expecting 70 study participants
Last Updated