Stroke clinical trials at University of California Health
38 in progress, 21 open to eligible people
Milvexian in Participants After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack- LIBREXIA-STROKE
open to eligible people ages 40 years and up
The purpose of this study is to evaluate whether milvexian compared to placebo reduce the risk of recurrent ischemic stroke.
at UC Davis UC Irvine UCLA
Anticoagulation in ICH Survivors for Stroke Prevention and Recovery
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open to eligible people ages 18 years and up
Primary Aim: To determine if apixaban is superior to aspirin for prevention of the composite outcome of any stroke (hemorrhagic or ischemic) or death from any cause in patients with recent ICH and atrial fibrillation (AF). Secondary Aim: To…
at UC Davis UC Irvine UCLA UCSF
Comparing Different Rehabilitation Exercise Strategies for Improving Arm Recovery After Stroke
open to eligible people ages 18-84
The purpose of this research study is to measure the effect of participating in extra arm exercise in addition to standard rehabilitation exercises in the Acute Rehabilitation Unit. This study will compare two different ways to perform the extra arm …
at UC Irvine
Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis
open to eligible people ages 30 years and up
The primary goal of the trial is to determine if the experimental arms (rivaroxaban or ticagrelor or both) are superior to the clopidogrel arm for lowering the 1-year rate of ischemic stroke, intracerebral hemorrhage, or vascular death.
at UC Davis UC Irvine UCLA UCSD
ECoG BMI for Motor and Speech Control
open to eligible people ages 21 years and up
Test the feasibility of using electrocorticography (ECoG) signals to control complex devices for motor and speech control in adults severely affected by neurological disorders.
at UCSF
GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study
open to eligible people ages 18-70
This study will assess the safety and effectiveness of GORE® CARDIOFORM Septal Occluder in a post approval setting and evaluate the quality of operator education and training and transferability of trial experience to a post-market setting.
at UCSF
Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial
open to eligible people ages 18-80
The objective of the rFVIIa for Acute Hemorrhagic Stroke Administered at Earliest Time (FASTEST) Trial is to establish the first treatment for acute spontaneous intracerebral hemorrhage (ICH) within a time window and subgroup of patients that is…
at UC Davis UC Irvine UCLA UCSD UCSF
SEACOAST 1- SEdAtion With COllAteral Support in Endovascular Therapy for Acute Ischemic Stroke
open to eligible people ages 18-110
SEACOAST 1 is a prospective, randomized, blinded endpoint trial comparing collateral vigor and clinical outcomes, with different forms of GA in patients with acute ischemic stroke due to anterior circulation large vessel occlusion (LVO) undergoing…
at UCLA
Short-term And Longer-term Cognitive Impact Of Neurochecks
open to eligible people ages 55-100
The proposed research plan seeks to understand the impact of sleep disruption in the Neurological Intensive Care Unit (ICU) on older patients with acute brain injury (ABI). In current practice, the neurocritical care community performs frequent…
at UCSD
Sleep for Stroke Management and Recovery Trial
open to eligible people ages 18 years and up
The purpose of this study is to determine whether treatment of obstructive sleep apnea (OSA) with positive airway pressure starting shortly after acute ischemic stroke (1) reduces recurrent stroke, acute coronary syndrome, and all-cause mortality 6…
at UC Davis UC Irvine UCLA UCSD UCSF
Strategy for Improving Stroke Treatment Response
open to eligible people ages 18 years and up
SISTER is a Phase-II, prospective, randomized, placebo-controlled, blinded, dose finding trial that aims to determine the safety and preliminary efficacy of TS23, a monoclonal antibody against the alpha-2 antiplasmin (a2-AP), in acute ischemic…
at UCSD
Telerehabilitation Early After CNS Injury
open to eligible people ages 18 years and up
The goal of this clinical trial is to assess the safety and feasibility of providing extra doses of rehabilitation therapy for persons with a recent stroke, traumatic brain injury (TBI) and/or spinal cord injury (SCI). The therapy treatment targets…
at UCLA
Cognition and Imaging With Tigertriever
open to eligible people ages 18-75
The objective of the COGNITIVE Study is to evaluate whether successful reperfusion with Tigertriever is associated with cognitive benefit.
at UCLA
Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
open to eligible people ages 18 years and up
The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke. The purpose of the study is to help doctors identify patients …
at UCLA UCSD
Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future
open to eligible people ages 18-100
Durable left ventricular assist devices (dLVAD) have been increasingly utilized since the mid to late 1990s, with an uptick of utility starting in 2010 following expanded indications for therapy to not only include a bridge to transplantation…
at UCSF
Neonatal Seizure Registry, GEnetics of Post-Neonatal Epilepsy
open to all eligible people
The NSR-GENE study is a longitudinal cohort study of approximately 300 parent-child trios from the Neonatal Seizure Registry and participating site outpatient clinics that aims to evaluate whether and how genes alter the risk of post-neonatal…
at UCSF
NOninVasive Intracranial PrEssure from Transcranial DoppLer Ultrasound Development of a Comprehensive Database of Multimodality Monitoring Signals for Brain-Injured Patients
open to eligible people ages 18 years and up
This is an observational study in neurocritical care units at University of California San Francisco Medical Center (UCSFMC), Zuckerberg San Francisco General Hospital (ZSFGH), UC Davis, and Emory University. In this study, the investigators will…
at UC Davis UCSF
Platelet Expression of FcγRIIa and Arterial Hemodynamics to Predict Recurrent Stroke in Intracranial Atherosclerosis
open to eligible people ages 30 years and up
An observational study to determine if individuals with increased platelet FcyRIIa will have a higher risk of ischemic events.
at UCLA
Somatic Dysfunction in Patients With Acute Cerebrovascular Disease
open to eligible people ages 18 years and up
The goals of this observational study are to test the reliability of a new, standardized physical examination method to identify motion problems within joints or groups of joints among adult asymptomatic volunteers and in patients hospitalized with…
at UC Davis
Stroke Recovery Initiative - Registry for Stroke Research Studies
open to eligible people ages 18 years and up
The Stroke Recovery Initiative is a nation-wide participant recruitment registry that connects people who have had a stroke with researchers who are working to develop new approaches to improve recovery after stroke.
at UCSF
Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials
open to eligible people ages 18 years and up
VERIFY will validate biomarkers of upper extremity (UE) motor outcome in the acute ischemic stroke window for immediate use in clinical trials, and explore these biomarkers in acute intracerebral hemorrhage. VERIFY will create the first multicenter, …
at UCLA UCSF
Test Asundexian for Preventing a Stroke Caused by a Clot in Participants After an Acute Ischemic Stroke or After a High-risk Transient Ischemic Attack, a So-called Mini Stroke
Sorry, in progress, not accepting new patients
Researchers are looking for a better way to prevent an ischemic stroke which occurs when a blood clot travelled to the brain in people who within the last 72 hours had: - an acute stroke due to a blood clot that formed outside the heart (acute…
at UC Irvine UCLA
AMPLATZER PFO Occluder Post Approval Study
Sorry, in progress, not accepting new patients
The purpose of this single arm, multi-center study is to confirm the safety and effectiveness of the AMPLATZER™ PFO Occluder in the post Approval Setting.
at UCLA UCSF
BCI-FES Therapy for Stroke Rehabilitation
Sorry, in progress, not accepting new patients
There are over 7 million stroke survivors in the US alone, with approximately 795,000 new cases annually. Despite the best available physiotherapy, 30-60% of stroke survivors remain affected by difficulty walking, with foot weakness often being the…
at UC Irvine
Determinants of the Effectiveness of Robot-assisted Hand Movement Training
Sorry, in progress, not accepting new patients
The investigators would like to investigate the effectiveness of somatosensory training for robot-assisted hand motor rehabilitation after stroke.
at UC Irvine
EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction
Sorry, in progress, not accepting new patients
The primary objective of this study is to evaluate the effectiveness of early treatment with evolocumab plus routine lipid management vs routine lipid management alone when administered in the acute setting to reduce myocardial infarction, ischemic…
at UC Irvine UCLA
Focal Cerebral Arteriopathy Steroid Trial
Sorry, accepting new patients by invitation only
This comparative effectiveness trial (CET) in children with suspected focal cerebral arteriopathy (FCA) presenting with arterial ischemic stroke (AIS) or transient ischemic attack (TIA) will compare the use of early corticosteroid treatment (Arm A)…
at UCSF
Hand Rehabilitation Study for Stroke Patients
Sorry, in progress, not accepting new patients
The purpose of this study is to find out what are the best settings for applying electrical nerve stimulation over the skin for the short-term improvement of hand dysfunction after a stroke. The ultimate goal is to some day design an effective…
at UCSF
Infliximab Therapy for Dolichoectactic Vertebrobasilar Aneurysms
Sorry, accepting new patients by invitation only
Patients harboring dolichoectactic vertebrobasilar (DVB) aneurysms are at risk of suffering SAH, ischemic stroke, and/or brainstem compression and many patients are not offered invasive treatment due to the futility of existing surgical methods.…
at UCSF
MIND: Artemis in the Removal of Intracerebral Hemorrhage
Sorry, in progress, not accepting new patients
The primary objective of this multicenter randomized controlled study is to compare the safety and efficacy of minimally invasive hematoma evacuation with the Artemis Neuro Evacuation Device to best medical management for the treatment of…
at UCLA
Reducing Blood Pressure in Patients With High Cardiovascular Risk in the Safety-Net
Sorry, not currently recruiting here
BP-REACH is a study of a team-based (pharmacist and health coach) program for lowering blood pressure for people with a prior stroke or heart attack in the Los Angeles Department of Health Services public healthcare system. The goal of this clinical …
at UC Irvine UCLA
Telerehabilitation in the Home After Stroke
Sorry, not yet accepting patients
The purpose of this research study is to evaluate whether telerehabilitation targeting arm movement, when added to usual care, improves arm function and reduces global disability after stroke, compared to usual care alone. Patients with arm weakness …
at UCLA
Transcranial Direct Current Stimulation for Treatment of Acute Ischemic Stroke
Sorry, not yet accepting patients
Many patients with acute ischemic stroke are ineligible for currently available standard treatments (clot-busting medication, also known as intravenous thrombolytic or mechanical removal of a clot), and many are non-responders, resulting in a low…
at UCLA UCSF
Cardiovascular Health Study (CHS)
Sorry, in progress, not accepting new patients
To determine the extent to which known risk factors predict coronary heart disease and stroke in the elderly, to assess the precipitants of coronary heart disease and stroke in the elderly, and to identify the predictors of mortality and functional…
at UC Davis
VQm PHM on Pulmonary Health Parameters for ICU
Sorry, not yet accepting patients
The goal of this observational study is to compare pulmonary health parameter measurements from the VQm PHM™ to existing clinical measurements. The main questions it aims to answer are: - Confirm the performance of non-invasive pulmonary health…
at UC Davis
Neonatal Seizure Registry - Developmental Functional EValuation
Sorry, in progress, not accepting new patients
The NSR-DEV study is a longitudinal cohort study of around 280 Neonatal Seizure Registry participants that aims to evaluate childhood outcomes after acute symptomatic neonatal seizures, as well as examine risk factors for developmental disabilities…
at UCSF
Treatment With Endovascular Intervention for STroke Patients With Existing Disability
Sorry, not currently recruiting here
TESTED will compare the risks and benefits of endovascular thrombectomy (EVT) to medical management (no EVT) in ischemic stroke patients who have a blockage in one of the large blood vessels in the brain and have a moderate-to-severe disability…
at UCLA
Vascular Events In Surgery patIents cOhort evaluatioN - Cardiac Surgery
Sorry, in progress, not accepting new patients
Worldwide over 2 million adults (>30,000 Canadians) undergo heart surgery annually. Although heart surgery provides important survival benefits, it is associated with potential major complications such as death, stroke, and heart attack. There is…
at UCLA
Our lead scientists for Stroke research studies include Jason Hinman, MD, PhD Karunesh Ganguly, MD, PhD Calvin H. Hirsch, MD May Nour, MD, PhD Heather J Fullerton, MD, MAS David Reinkensmeyer, Ph.D Mersedeh Bahr Hosseini, MD Steven C. Cramer, MD Katherine Mun, MD Latisha K. Sharma, MD Michael Su, MD Sammy Elmariah, MD Jamie Labuzetta An Do, MD Alejandra Casillas, MD Kwan Ng Satoshi Tateshima, MD Hannah C Glass, MDCM, MAS David Liebeskind Radoslav Raychev, MD Eric H. Yang, MD Daniel Cooke Jeffrey Saver, MD Royya Modir, MD Alan Yee, D.O. Alon Avidan, MD, MPH Anthony S. Kim, MD, MAS.
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