for people ages 5 years and up (full criteria)
study started
completion around



Multi-center observational study to evaluate the histopathology and transcriptome of cutaneous lesions in patients with several different types of vasculitis.


This study employs a multi-center approach to evaluate cutaneous vasculitis across several forms of idiopathic vasculitis. Patients with cutaneous manifestations of vasculitis will be evaluated by teams of primary vasculitis care providers and Dermatologists in order to facilitate optimal selection of patients and sampling of lesions.

A punch skin biopsy at a site of active vasculitis will be the source of material for histopathologic and transcriptomic evaluation. The histopathology of cutaneous vasculitis will be characterized using a standardized approach.


Cryoglobulinemic Vasculitis (CV), Drug-induced Vasculitis, Eosinophilic Granulomatosis With Polyangiitis (EGPA), IgA Vasculitis, Isolated Cutaneous Vasculitis, Granulomatosis With Polyangiitis (GPA), Microscopic Polyangiitis (MPA), Polyarteritis Nodosa (PAN), Urticarial Vasculitis, Vasculitis, DIV, CSS, EGPA, HSP, GPA, MPA, PAN, Wegeners, Granulomatosis with Polyangiitis, Microscopic Polyangiitis, Systemic Vasculitis, Churg-Strauss Syndrome, Polyarteritis Nodosa, Vascular Skin Diseases


You can join if…

Open to people ages 5 years and up

  • Have a cutaneous lesion (purpuric macules, palpable purpura, retiform purpura, nodules, ulcers, or urticarial) believed to be related to active vasculitis
  • Have a suspected or confirmed diagnosis of:
  • Be willing and able to provide written informed consent (or assent for those under

You CAN'T join if...

  • You are less than five years old
  • Considered not to be a candidate for a biopsy or have a higher risk of developing an infection, bleeding, etc., from the biopsy, or a doctor believes that the risks for you participating in this study do not outweigh the potential benefit of learning information from your biopsy
  • You have a neutrophil count (type of white blood cell) less than 1500/mm3, platelet count less than 50,000/mm3, or a hemoglobin less than 7 g/dL
  • You have an uncontrolled disease that could prevent you from completing the study procedures
  • You have an active infection at or near the potential biopsy site, have poor circulation, or have bony prominence or other structure that would increase your risk of complications if you participated in this study
  • You are pregnant or nursing
  • You are not able to provide informed consent


  • University of California, Los Angeles accepting new patients
    Los Angeles California 90095 United States
  • Oregon Health & Science University completed
    Portland Oregon United States
  • University of Toronto Mount Sinai Hospital accepting new patients
    Toronto Ontario M5G 1X5 Canada


accepting new patients
Start Date
Completion Date
Peter Merkel
Related Info
Study Type
Expecting 50 study participants
Last Updated