Summary

for people ages 18 years and up (full criteria)
at UCLA
study started
estimated completion:
Janine Trevillyan (ucla)

Description

Summary

This is a small observational study aimed at observing differences in platelet function in HIV patients on abacavir versus tenofovir based anti-HIV drugs. There is some correlation between platelet activation and cardiovascular disease- this study will act as a pilot to see if platelet activation among abacavir users may explain the correlation between abacavir and cardiovascular disease in HIV positive patients. This study will enroll 44 participants total; 22 on abacavir-based treatment, 22 on tenofovir-based treatment. There is only one study visit which includes a blood draw, physical assessment, and review of medical history.

Official Title

Differences in Platelet Function in Patients on Abacavir Versus Tenofovir Based Antiretroviral Regimens

Keywords

Cardiovascular Diseases Platelet Aggregation, Spontaneous HIV/AIDS Blood Platelet Disorders Tenofovir Abacavir Platelet aggregation

Eligibility

You can join if…

Open to people ages 18 years and up

  • HIV positive
  • Stable antiretroviral regimen for > 3months containing either abacavir or tenofovir
  • Suppressed HIV viral load

You CAN'T join if...

  • Current cigarette smoking
  • Pre-existing platelet disorder
  • current or recent (last 6 months) antiplatelet therapy
  • pregnancy

Location

  • Clinical AIDS Research and Education Center accepting new patients
    Los Angeles California 90025 United States

Lead Scientist

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, Los Angeles
ID
NCT03081572
Study Type
Observational
Last Updated