Summary

Eligibility
for people ages 0-24 (full criteria)
Location
at UCSF
Dates
study started
completion around
Principal Investigator
by Alexis Melton, MD (ucsf)

Description

Summary

This study will validate a previously developed pediatric prognostic biomarker algorithm aimed at improving prediction of risk for the later development of chronic graft-versus-host disease (cGvHD) in children and young adults undergoing allogeneic hematopoietic stem cell transplant.

By developing an early risk stratification of patients into low-, intermediate-, and high-risk for future cGvHD development (based upon their biomarker profile, before the onset of cGvHD), pre-emptive therapies aimed at preventing the onset of cGvHD can be developed based upon an individual's biological risk profile.

This study will also continue research into diagnostic biomarkers of cGvHD, and begin work into biomarker models that predict clinical response to cGvHD therapies.

Official Title

Biomarker Verification in Pediatric Chronic Graft-Versus-Host Disease: Applied Biomarkers to Minimize Long Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) / Pediatric Transplantation & Cellular Therapy Consortium (PTCTC)

Details

Keywords

Chronic Graft-versus-Host-Disease, Leukemia, Allogeneic Hematopoietic Stem Cell Transplantation, Blood Cancer, Non-Malignant Hematologic and Lymphocytic Disorder, cGvHD, HSCT, L-aGvHD, Biomarkers, Blood, Pediatric, Adolescent, Hematopoietic Stem Cell Transplant, Late acute Graft-versus-Host Disease, Hematologic Neoplasms, Bronchiolitis Obliterans Syndrome, Hematologic Diseases, Graft vs Host Disease, Allogeneic HSC Transplant recipients

Eligibility

Locations

  • University of California San Francisco accepting new patients
    San Francisco California 94158 United States
  • Oregon Health & Science University Knight Cancer Institute accepting new patients
    Portland Oregon 97239-3098 United States

Lead Scientist at University of California Health

  • Alexis Melton, MD (ucsf)
    Volunteer Associate Clinical Professor, Pediatrics, School of Medicine. Authored (or co-authored) 26 research publications

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of British Columbia
ID
NCT04372524
Study Type
Observational
Participants
Expecting 350 study participants
Last Updated