Summary

Eligibility
for people ages 21 years and up (full criteria)
Healthy Volunteers
healthy people welcome
Location
at UCSF
Dates
study started
completion around
Principal Investigator
by Gregory M Marcus, MD, MAS (ucsf)
Headshot of Gregory M Marcus
Gregory M Marcus

Description

Summary

Despite recreational cannabis now being legal in 23 states, where more than 100 million Americans reside, studies on the actual health effects are limited. This study is a randomized trial, where each participant will be instructed to consume or avoid cannabis on randomly assigned days during a 14-day monitoring period. The goal of this study is to answer the question:

"Does cannabis use increase the frequency of 'early' and abnormal heart beats?"

During the 14-day period, participants will wear an external heart monitor, a glucose monitor, and a fitness tracker to track heart rhythm, glucose levels, step counts, and sleep health. Participants will use a mobile app or a text messaging service for daily instructions/reminders on cannabis use, and short surveys. The investigators ask that participants smoke or vape cannabis at least once on days they are instructed to consume cannabis. Compelling evidence of heart and other health effects would be important to the clinical care of our patients.

Official Title

Marijuana and Acute Risk of Arrhythmia- Joint Abstinence and Exposure

Details

This study is designed as a case-crossover randomized trial, where each participant will be instructed to consume or avoid inhaled cannabis on randomly assigned days during a 14-day monitoring period. Participants will be asked to smoke or vape cannabis at least once on days they are instructed to consume cannabis. Participants will also wear an external electrocardiographic (ECG) monitor, a continuous glucose monitor, and a fitness tracker for up to two weeks while utilizing a mobile application or text messaging service to receive daily instructions/reminders on cannabis use, and short surveys. The investigators will compare participant self-report of cannabis consumption, glucose monitoring, fitness levels, sleep health, and heart rhythm data in order to better understand the relationship between acute cannabis consumption and heart rhythm changes. A total of 100 participants will be enrolled at the UCSF study site.

Keywords

Premature Atrial Contractions, Premature Ventricular Contractions, Cannabis, Marijuana, Weed, Arrhythmias, Cardiac Ectopy, PACs, PVCs, Heart Rhythm, Premature Birth, Ventricular Premature Complexes, Atrial Premature Complexes, Randomized instructions

Eligibility

You can join if…

Open to people ages 21 years and up

  1. Are age 21 or older
  2. Have a smartphone
  3. Are able to use the Eureka mobile application and Mosio text messaging software
  4. Have inhaled cannabis in the past month and on at least four different days in the same week in the past year
  5. Are willing to consume and abstain from inhaled cannabis for no more than two consecutive days as instructed over the 14-day trial period

You CAN'T join if...

  1. Currently pregnant or trying to get pregnant
  2. Have a medical reason to avoid cannabis
  3. Are unwilling to avoid all forms of cannabis consumption on days instructed to abstain from cannabis
  4. Are currently taking anti-arrhythmic medications
  5. Have a history of atrial fibrillation or heart failure
  6. Have congenital heart disease
  7. Have an implantable cardioverter-defibrillator or pacemaker
  8. Have had a previous cardiac ablation procedure

Locations

  • UCSF Medical Center at Parnassus accepting new patients
    San Francisco California 94143 United States
  • UCSF Medical Center at Mission Bay accepting new patients
    San Francisco California 94158 United States

Lead Scientist at University of California Health

  • Gregory M Marcus, MD, MAS (ucsf)
    Dr. Gregory Marcus is a specialist in the treatment of arrhythmias, including mapping and catheter ablation for atrial fibrillation, supraventricular tachycardias and ventricular arrhythmias. He is also an expert in pacemaker, biventricular device and defibrillator implantation. RESEARCH Dr. Marcus is Associate Chief of Cardiology for Research at UCSF Health. He is also an Ass…

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT06021613
Study Type
Interventional
Participants
Expecting 100 study participants
Last Updated