Summary

Eligibility
for people ages 40-80 (full criteria)
Healthy Volunteers
healthy people welcome
Location
at UCLA UCSF
Dates
study started
completion around
Principal Investigator
by Prescott Woodruff, MD (ucsf)Igor Barjaktarevic, MD (ucla)
Headshot of Prescott Woodruff
Prescott Woodruff

Description

Summary

SPIROMICS I and SPIROMICS II are observational studies of Chronic Obstructive Pulmonary Disease (COPD).

SPIROMICS I had two main aims: (1) To find groups of patients with COPD who share certain characteristics; (2) To find new ways of measuring whether or not COPD is getting worse and so provide new ways of testing whether a new treatment is working.

SPIROMICS II has three primary aims. Aim 1 is to define the natural history of "Smokers with symptoms despite preserved spirometry" and characterize the airway mucus abnormalities underlying this condition. Aim 2 is to determine the radiographic precursor lesion(s) for emphysema, and identify the molecular phenotypes underlying airway disease and emphysema. Aim 3 is to advance understanding of the biology of COPD exacerbations through analysis of predisposing baseline phenotypes, exacerbation triggers and host inflammatory response.

Official Title

Subpopulations and Intermediate Outcome Measures in COPD Study

Details

Keywords

COPD, Chronic Obstructive Pulmonary Disease, Chronic Bronchitis, Emphysema, Bronchitis, Obstructive Lung Diseases, Severe COPD, Mild/Moderate COPD

Eligibility

Locations

  • University of California at Los Angeles
    Los Angeles California 90095 United States
  • University of California at San Francisco
    San Francisco California 94143 United States

Lead Scientists at University of California Health

  • Prescott Woodruff, MD (ucsf)
    I. Mentoring in Translational Research II. The identification of molecular sub-phenotypes of asthma and COPD III. Mechanisms of airway inflammation and remodeling in lung diseases IV. Development of blood-based diagnostic tests for lung disease using genomic approaches V. Clinical Trials in asthma and COPD
  • Igor Barjaktarevic, MD (ucla)
    HS Associate Clinical Professor, Medicine. Authored (or co-authored) 184 research publications

Details

Status
in progress, not accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of North Carolina, Chapel Hill
Links
Study Website
ID
NCT01969344
Study Type
Observational
Participants
About 2981 people participating
Last Updated