for males ages 45-80 (full criteria)
study started
estimated completion



This is a blinded and placebo-controlled study of topical testosterone replacement therapy (TRT) in symptomatic hypogonadal men with increased risk for cardiovascular (CV) disease.

Official Title

Testosterone Replacement Therapy for Assessment of Long-term Vascular Events and Efficacy ResponSE in Hypogonadal Men (TRAVERSE) Study


Hypogonadism Cardiovascular Diseases cardiovascular (CV) disease AndroGel testosterone replacement therapy (TRT) Testosterone Testosterone undecanoate Testosterone enanthate Testosterone 17 beta-cypionate Methyltestosterone


You can join if…

Open to males ages 45-80

  • Men between 45 and 80 years age
  • Participants with low serum testosterone concentrations (< 300 ng/dL) who exhibit at least one sign or symptom of hypogonadism and have evidence of cardiovascular (CV) disease or are at an increased risk for CV disease.

You CAN'T join if...

  • Participants with congenital or acquired hypogonadism for whom long-term therapy with placebo would not be medically appropriate
  • Participants with prostate specific antigen (PSA) > 3.0 ng/mL (or 1.5 if on 5-alpha reductase inhibitors)
  • Participants who have been treated with testosterone in the past 6 months and for whom testosterone therapy is contraindicated
  • Confirmed testosterone < 100 ng/dL
  • Body Mass Index (BMI) > 50
  • Hemoglobin A1c (HbA1C) > 11%
  • Hematocrit (Hct) > 50%
  • Estimated Glomerular Filtration Rate (eGFR) < 30 ml/min
  • History of deep vein thrombosis or pulmonary embolism or prostate cancer or heart failure (Class III and IV).


  • Olive View UCLA Medical Center /ID# 206131 accepting new patients
    Sylmar California 91342-1437 United States
  • Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center /ID# 170400 accepting new patients
    Torrance California 90502-2006 United States
  • "Comprehensive Oncology Centre" - Vratsa EOOD /ID# 168252 not yet accepting patients
    San Diego California 92161-0002 United States
  • Pacific Oaks Medical Group /ID# 170540 accepting new patients
    Beverly Hills California 90211 United States
  • Tower Urology /ID# 170330 accepting new patients
    Los Angeles California 90048 United States
  • Integrated Research Center, Inc. /ID# 170391 accepting new patients
    San Diego California 92117-4946 United States
  • Ritchken & First MD's /ID# 201341 accepting new patients
    San Diego California 92117-4946 United States
  • Anthony Mills, MD, Inc. /ID# 170571 accepting new patients
    West Hollywood California 90069-3701 United States
  • NewportNativeMD, Inc. /ID# 168110 accepting new patients
    Newport Beach California 92663 United States
  • Cedars-Sinai Medical Group (MGOE) /ID# 170383 not yet accepting patients
    Encino California 91436-2731 United States


accepting new patients
Start Date
Completion Date
Phase 4
Study Type
Last Updated