Summary

Eligibility
for people ages 22-70 (full criteria)
Location
at UCSF
Dates
study started
completion around
Principal Investigator
by Andrew Krystal, MD, MS (ucsf)
Headshot of Andrew Krystal
Andrew Krystal

Description

Summary

Neurons are specialized types of cells that are responsible for carrying out the functions of the brain. Neurons communicate with electrical signals. In diseases such as major depression this electrical communication can go awry. One way to change brain function is using electrical stimulation to help alter the communication between groups of neurons in the brain.

The purpose of this study is to test a personalized approach to brain stimulation as an intervention for depression. The study researchers will use a surgically implanted device to measure each individual's brain activity related to his/her depression. The researchers will then use small electrical impulses to alter that brain activity and measure whether these changes help reduce depression symptoms. This study is intended for patients with major depression whose symptoms have not been adequately treated with currently available therapies.

The device used in this study is called the NeuroPace Responsive Neurostimulation (RNS) System. It is currently FDA approved to treat patients with epilepsy. The study will test whether personalized responsive neurostimulation can safely and effectively treat depression.

Official Title

Closed-Loop Deep Brain Stimulation for Treatment-Resistant Depression

Details

Keywords

Major Depressive Disorder, Depression, Treatment-resistance, Deep brain stimulation, Closed-loop, Biomarker, Responsive neurostimulation, Brain surgery, Depressive Disorder, Stimulation-ON, Stimulation-OFF

Eligibility

Location

  • University of California, San Francisco accepting new patients
    San Francisco California 94143 United States

Lead Scientist at University of California Health

  • Andrew Krystal, MD, MS (ucsf)
    Dr. Krystal is the Ray and Dagmar Dolby Distinguished Professor in the Departments of Psychiatry and Neurology, Vice-Chair for Research in the Department of Psychiatry, Director of the Dolby Family Center for Mood Disorders, Director of the UCSF Interventional Psychiatry Program and Co-Director of the TMS & Neuromodulation Clinic.

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Andrew Krystal
ID
NCT04004169
Study Type
Interventional
Participants
Expecting 12 study participants
Last Updated