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Stroke clinical trials at University of California Health

42 in progress, 21 open to eligible people

Showing trials for
  • Milvexian in Participants After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack- LIBREXIA-STROKE

    open to eligible people ages 40 years and up

    The purpose of this study is to evaluate whether milvexian compared to placebo reduce the risk of recurrent ischemic stroke.

    at UC Davis UC Irvine UCLA

  • Test Asundexian for Preventing a Stroke Caused by a Clot in Participants After an Acute Ischemic Stroke or After a High-risk Transient Ischemic Attack, a So-called Mini Stroke

    open to eligible people ages 18 years and up

    Researchers are looking for a better way to prevent an ischemic stroke which occurs when a blood clot travelled to the brain in people who within the last 72 hours had: - an acute stroke due to a blood clot that formed outside the heart (acute…

    at UC Davis UC Irvine UCLA

  • Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

    “Volunteer for research and contribute to discoveries that may improve health care for you, your family, and your community!”

    open to eligible people ages 18 years and up

    Primary Aim: To determine if apixaban is superior to aspirin for prevention of the composite outcome of any stroke (hemorrhagic or ischemic) or death from any cause in patients with recent ICH and atrial fibrillation (AF). Secondary Aim: To…

    at UC Davis UC Irvine UCLA UCSF

  • Comparing Different Rehabilitation Exercise Strategies for Improving Arm Recovery After Stroke

    open to eligible people ages 18-84

    The purpose of this research study is to measure the effect of participating in extra arm exercise in addition to standard rehabilitation exercises in the Acute Rehabilitation Unit. This study will compare two different ways to perform the extra arm …

    at UC Irvine

  • Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis

    open to eligible people ages 30 years and up

    The primary goal of the trial is to determine if the experimental arms (rivaroxaban or ticagrelor or both) are superior to the clopidogrel arm for lowering the 1-year rate of ischemic stroke, intracerebral hemorrhage, or vascular death.

    at UC Davis UC Irvine UCLA UCSD

  • ECoG BMI for Motor and Speech Control

    open to eligible people ages 21 years and up

    Test the feasibility of using electrocorticography (ECoG) signals to control complex devices for motor and speech control in adults severely affected by neurological disorders.

    at UCSF

  • GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study

    open to eligible people ages 18-70

    This study will assess the safety and effectiveness of GORE® CARDIOFORM Septal Occluder in a post approval setting and evaluate the quality of operator education and training and transferability of trial experience to a post-market setting.

    at UCLA UCSF

  • Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial

    open to eligible people ages 18-80

    The objective of the rFVIIa for Acute Hemorrhagic Stroke Administered at Earliest Time (FASTEST) Trial is to establish the first treatment for acute spontaneous intracerebral hemorrhage (ICH) within a time window and subgroup of patients that is…

    at UC Davis UC Irvine UCLA UCSD UCSF

  • SEACOAST 1- SEdAtion With COllAteral Support in Endovascular Therapy for Acute Ischemic Stroke

    open to eligible people ages 18-110

    SEACOAST 1 is a prospective, randomized, blinded endpoint trial comparing collateral vigor and clinical outcomes, with different forms of GA in patients with acute ischemic stroke due to anterior circulation large vessel occlusion (LVO) undergoing…

    at UCLA

  • Short-term And Longer-term Cognitive Impact Of Neurochecks

    open to eligible people ages 55-100

    The proposed research plan seeks to understand the impact of sleep disruption in the Neurological Intensive Care Unit (ICU) on older patients with acute brain injury (ABI). In current practice, the neurocritical care community performs frequent…

    at UCSD

  • Sleep for Stroke Management and Recovery Trial

    open to eligible people ages 18 years and up

    The purpose of this study is to determine whether treatment of obstructive sleep apnea (OSA) with positive airway pressure starting shortly after acute ischemic stroke (1) reduces recurrent stroke, acute coronary syndrome, and all-cause mortality 6…

    at UC Davis UC Irvine UCLA UCSD UCSF

  • Spinal COrd NeuromodulaTor by SpIneX and ScoNE to Treat NeurogeniC BladdEr - SCONE "CONTINENCE" Clinical Study

    open to eligible people ages 18-75

    The purpose of this study is to evaluate the effectiveness and safety of SCONE neuromodulation therapy after 12 weeks of therapy in comparison to inactive sham control in improving symptoms of Neurogenic Lower Urinary Tract Dysfunction

    at UCSD

  • Strategy for Improving Stroke Treatment Response

    open to eligible people ages 18 years and up

    SISTER is a Phase-II, prospective, randomized, placebo-controlled, blinded, dose finding trial that aims to determine the safety and preliminary efficacy of TS23, a monoclonal antibody against the alpha-2 antiplasmin (a2-AP), in acute ischemic…

    at UCSD

  • Telerehabilitation Early After CNS Injury

    open to eligible people ages 18 years and up

    The goal of this clinical trial is to assess the safety and feasibility of providing extra doses of rehabilitation therapy for persons with a recent stroke, traumatic brain injury (TBI) and/or spinal cord injury (SCI). The therapy treatment targets…

    at UCLA

  • Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

    open to eligible people ages 18 years and up

    The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke. The purpose of the study is to help doctors identify patients …

    at UCLA UCSD

  • Neonatal Seizure Registry, GEnetics of Post-Neonatal Epilepsy

    open to all eligible people

    The NSR-GENE study is a longitudinal cohort study of approximately 300 parent-child trios from the Neonatal Seizure Registry and participating site outpatient clinics that aims to evaluate whether and how genes alter the risk of post-neonatal…

    at UCSF

  • NOninVasive Intracranial PrEssure from Transcranial DoppLer Ultrasound Development of a Comprehensive Database of Multimodality Monitoring Signals for Brain-Injured Patients

    open to eligible people ages 18 years and up

    This is an observational study in neurocritical care units at University of California San Francisco Medical Center (UCSFMC), Zuckerberg San Francisco General Hospital (ZSFGH), UC Davis, and Emory University. In this study, the investigators will…

    at UC Davis UCSF

  • Platelet Expression of FcγRIIa and Arterial Hemodynamics to Predict Recurrent Stroke in Intracranial Atherosclerosis

    open to eligible people ages 30 years and up

    An observational study to determine if individuals with increased platelet FcyRIIa will have a higher risk of ischemic events.

    at UCLA

  • Somatic Dysfunction in Patients With Acute Cerebrovascular Disease

    open to eligible people ages 18 years and up

    The goals of this observational study are to test the reliability of a new, standardized physical examination method to identify motion problems within joints or groups of joints among adult asymptomatic volunteers and in patients hospitalized with…

    at UC Davis

  • Stroke Recovery Initiative - Registry for Stroke Research Studies

    open to eligible people ages 18 years and up

    The Stroke Recovery Initiative is a nation-wide participant recruitment registry that connects people who have had a stroke with researchers who are working to develop new approaches to improve recovery after stroke.

    at UCSF

  • Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials

    open to eligible people ages 18 years and up

    VERIFY will validate biomarkers of upper extremity (UE) motor outcome in the acute ischemic stroke window for immediate use in clinical trials, and explore these biomarkers in acute intracerebral hemorrhage. VERIFY will create the first multicenter, …

    at UCLA UCSF

  • AMPLATZER PFO Occluder Post Approval Study

    Sorry, in progress, not accepting new patients

    The purpose of this single arm, multi-center study is to confirm the safety and effectiveness of the AMPLATZER™ PFO Occluder in the post Approval Setting.

    at UCLA UCSF

  • AMPLATZER™ Amulet™ LAA Occluder Trial

    Sorry, in progress, not accepting new patients

    The Amulet™ device will be evaluated for safety and efficacy by demonstrating its performance is non-inferior to the commercially available WATCHMAN® left atrial appendage closure device in patients with non-valvular atrial fibrillation. Patients…

    at UC Davis

  • BCI-FES Therapy for Stroke Rehabilitation

    Sorry, in progress, not accepting new patients

    There are over 7 million stroke survivors in the US alone, with approximately 795,000 new cases annually. Despite the best available physiotherapy, 30-60% of stroke survivors remain affected by difficulty walking, with foot weakness often being the…

    at UC Irvine

  • Determinants of the Effectiveness of Robot-assisted Hand Movement Training

    Sorry, in progress, not accepting new patients

    The investigators would like to investigate the effectiveness of somatosensory training for robot-assisted hand motor rehabilitation after stroke.

    at UC Irvine

  • EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction

    Sorry, in progress, not accepting new patients

    The primary objective of this study is to evaluate the effectiveness of early treatment with evolocumab plus routine lipid management vs routine lipid management alone when administered in the acute setting to reduce myocardial infarction, ischemic…

    at UC Irvine UCLA

  • Focal Cerebral Arteriopathy Steroid Trial

    Sorry, accepting new patients by invitation only

    This comparative effectiveness trial (CET) in children with suspected focal cerebral arteriopathy (FCA) presenting with arterial ischemic stroke (AIS) or transient ischemic attack (TIA) will compare the use of early corticosteroid treatment (Arm A)…

    at UCSF

  • Hand Rehabilitation Study for Stroke Patients

    Sorry, in progress, not accepting new patients

    The purpose of this study is to find out what are the best settings for applying electrical nerve stimulation over the skin for the short-term improvement of hand dysfunction after a stroke. The ultimate goal is to some day design an effective…

    at UCSF

  • Infliximab Therapy for Dolichoectactic Vertebrobasilar Aneurysms

    Sorry, accepting new patients by invitation only

    Patients harboring dolichoectactic vertebrobasilar (DVB) aneurysms are at risk of suffering SAH, ischemic stroke, and/or brainstem compression and many patients are not offered invasive treatment due to the futility of existing surgical methods.…

    at UCSF

  • Laminar LAAX Pivotal IDE Study

    Sorry, accepting new patients by invitation only

    The goal of this clinical trial is to compare the Laminar Left Atrial Appendage Closure System to commercially available left atrial appendage closure devices. This procedure is for patients with non-valvular atrial fibrillation who are at increased …

    at UC Davis

  • MIND: Artemis in the Removal of Intracerebral Hemorrhage

    Sorry, in progress, not accepting new patients

    The primary objective of this multicenter randomized controlled study is to compare the safety and efficacy of minimally invasive hematoma evacuation with the Artemis Neuro Evacuation Device to best medical management for the treatment of…

    at UCLA

  • Multi-arm Optimization of Stroke Thrombolysis

    Sorry, in progress, not accepting new patients

    The primary efficacy objective of the MOST trial is to determine if argatroban (100µg/kg bolus followed by 3µg/kg per minute for 12 hours) or eptifibatide (135µg/kg bolus followed by 0.75µg/kg/min infusion for two hours) results in improved 90-day…

    at UC Irvine UCSD UCSF

  • Reducing Blood Pressure in Patients With High Cardiovascular Risk in the Safety-Net

    Sorry, not currently recruiting here

    BP-REACH is a study of a team-based (pharmacist and health coach) program for lowering blood pressure for people with a prior stroke or heart attack in the Los Angeles Department of Health Services public healthcare system. The goal of this clinical …

    at UC Irvine UCLA

  • Telerehabilitation in the Home After Stroke

    Sorry, not yet accepting patients

    The purpose of this research study is to evaluate whether telerehabilitation targeting arm movement, when added to usual care, improves arm function and reduces global disability after stroke, compared to usual care alone. Patients with arm weakness …

    at UCLA

  • Transcranial Direct Current Stimulation for Treatment of Acute Ischemic Stroke

    Sorry, not yet accepting patients

    Many patients with acute ischemic stroke are ineligible for currently available standard treatments (clot-busting medication, also known as intravenous thrombolytic or mechanical removal of a clot), and many are non-responders, resulting in a low…

    at UCLA UCSF

  • Women's Health Initiative Strong and Healthy Study

    Sorry, in progress, not accepting new patients

    The WHISH trial applies state-of-the science behavioral principles and currently available technologies to deliver a physical activity intervention without face-to-face contact to ~25,000 older U.S. women expected to consent. It includes the…

    at UCSD

  • Cardiovascular Health Study (CHS)

    Sorry, in progress, not accepting new patients

    To determine the extent to which known risk factors predict coronary heart disease and stroke in the elderly, to assess the precipitants of coronary heart disease and stroke in the elderly, and to identify the predictors of mortality and functional…

    at UC Davis

  • VQm PHM on Pulmonary Health Parameters for ICU

    Sorry, not yet accepting patients

    The goal of this observational study is to compare pulmonary health parameter measurements from the VQm PHM™ to existing clinical measurements. The main questions it aims to answer are: - Confirm the performance of non-invasive pulmonary health…

    at UC Davis

  • Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future

    Sorry, not yet accepting patients

    Durable left ventricular assist devices (dLVAD) have been increasingly utilized since the mid to late 1990s, with an uptick of utility starting in 2010 following expanded indications for therapy to not only include a bridge to transplantation…

    at UCSF

  • Neonatal Seizure Registry - Developmental Functional EValuation

    Sorry, in progress, not accepting new patients

    The NSR-DEV study is a longitudinal cohort study of around 280 Neonatal Seizure Registry participants that aims to evaluate childhood outcomes after acute symptomatic neonatal seizures, as well as examine risk factors for developmental disabilities…

    at UCSF

  • Treatment With Endovascular Intervention for STroke Patients With Existing Disability

    Sorry, not currently recruiting here

    TESTED will compare the risks and benefits of endovascular thrombectomy (EVT) to medical management (no EVT) in ischemic stroke patients who have a blockage in one of the large blood vessels in the brain and have a moderate-to-severe disability…

    at UCLA

  • Vascular Events In Surgery patIents cOhort evaluatioN - Cardiac Surgery

    Sorry, in progress, not accepting new patients

    Worldwide over 2 million adults (>30,000 Canadians) undergo heart surgery annually. Although heart surgery provides important survival benefits, it is associated with potential major complications such as death, stroke, and heart attack. There is…

    at UCLA

Our lead scientists for Stroke research studies include .

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