Aphasia Physical EXercise Study: Randomized Trial

a study on Aphasia Ischemic Stroke Hemorrhagic Stroke Intracranial Hemorrhage Stroke

Summary

Eligibility
for people ages 18-80 (full criteria)
Location
at UCSF
Dates
study started
study ends around

Description

Summary

The goal of this clinical trial is to evaluate the effects of a high-intensity exercise program on recovery in individuals with post-stroke aphasia. The high-intensity exercise program has been specifically designed for individuals with post-stroke aphasia and includes an interval training full-body workout, which can increase cardiovascular fitness, improve muscle strength and motor performance, and maximize cognitive and language gains. The main question this study aims to answer is:

• Does participation in a high-intensity exercise program lead to changes in physical health, language, cognitive, motor recovery, psychological and/or psychosocial domains?

Participants will be randomly assigned to either a high-intensity exercise program (target intervention) or a low-intensity exercise program (control intervention) delivered over 12-weeks in a group setting.

Outcome measures will be collected once immediately after the intervention period and once during the following 12-week maintenance period to capture short- and long-term effects of the exercise program.

Official Title

High-intensity Exercise in Stroke Recovery: Randomized Trial

Keywords

Aphasia, Acquired, Aphasia, Aphasia, Fluent, Aphasia, Non-fluent, Aphasia Following Cerebral Infarction, Aphasia Following Nontraumatic Intracerebral Hemorrhage, physical exercise, high intensity interval training, cognition, physical fitness, balance, stroke, language, Wernicke Aphasia, Broca Aphasia, Motor Activity, High-intensity physical exercise, Low-intensity physical exercise

Eligibility

You can join if…

Open to people ages 18-80

  • Aphasia following ischemic or hemorrhagic stroke
  • Aphasia as determined by a standardized language test (Western Aphasia Battery Aphasia Quotient < 93.8 at study intake)
  • At least 6 months from the last stroke
  • Proficient in English before the stroke
  • At least 8 years of education
  • Between the ages of 18 and 80
  • Independent with ambulation without a device (single-point cane accepted)
  • Medically stable with no contraindications to participate in regular physical exercise as determined by the patients' own primary care provider or other treating provider.

You CAN'T join if...

  • Prior history of dementia, neurologic illness (other than stroke), or recent (last 3 years) substance abuse
  • Significant visual or hearing disabilities (e.g., neglect, uncorrected visual or hearing loss) that interfere with testing
  • Self-report uncontrolled cardiorespiratory and/or metabolic disorders incompatible with exercise

Locations

  • University of California, San Francisco accepting new patients
    San Francisco California 94143 United States
  • University of San Francisco accepting new patients
    San Francisco California 94118 United States
  • University of California, Berkeley accepting new patients
    Berkeley California 94720 United States
  • California State University, East Bay accepting new patients
    Hayward California 94542 United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, Berkeley
Links
Related Info
ID
NCT07281313
Study Type
Interventional
Participants
Expecting 120 study participants
Last Updated
Contact us about this trial