for females ages 18-50 (full criteria)
Healthy Volunteers
healthy people welcome
study started
estimated completion
Principal Investigator
by Danielle Roubinov, PhD (ucsf)
Photo of Danielle Roubinov
Danielle Roubinov



The overarching goal is to pilot the Attachment and Biobehavioral Catch-up (ABC) intervention for mothers with heightened depressive symptom and their children with heightened internalizing symptoms.

Official Title

Attachment and Biobehavioral Catch-up for Depression Intervention


Exposure to maternal depressive symptoms increases children's risk for developing anxiety and depressive symptoms ("internalizing symptoms"). Maternal depressive symptoms and children's internalizing symptoms may be reciprocally related over time. Optimal interventions for children's internalizing symptoms may involve treatment components for mothers, children, and the maternal-child relationship. The Attachment and Biobehavioral Catch-up (ABC) intervention is a empirically-supported, family-based treatment program that has been shown to be beneficial for children in varied high-risk family environments, but has yet to be tested among mothers and children recruited on the basis of heightened depressive and internalizing symptoms, respectively. The overarching goal is to examine the acceptability, feasibility, and preliminary effects of the ABC program on a sample of mother-child dyads (n = 20) with heightened depressive and internalizing symptoms. Our specific aims are: 1. To evaluate the feasibility and acceptability of ABC for mothers with depressive symptoms and their offspring with internalizing symptoms 2. To explore whether children who receive ABC show improvement in internalizing symptoms from pre- to post-intervention 3. To explore whether mothers who receive ABC show improvement in depressive symptoms from pre- to post-intervention 4. To explore whether parents and children who receive ABC show more adaptive physiological responses to stress from pre- to post-intervention


Depressive Symptoms Anxiety Symptoms Depression Attachment and Biobehavioral Catch-up (ABC) Intervention ABC


You can join if…

Open to females ages 18-50

  1. Mothers between 18 and 50 years of age with heightened depressive symptoms as determined by a score of 16 or higher on the Center for Epidemiologic Studies Depression Scale-Revised (CESD-R)
  2. Biological children (of mothers described above) between 2 and 4 years old with heightened internalizing symptoms as determined by a T-score of 60 or higher on the Childhood Behavior Checklist (CBCL)

You CAN'T join if...

  • Self-reported history of psychosis or active suicidality as defined by self-report of a specific suicide plan or recent attempt
  • Current pregnancy
  • Child diagnosis of autism
  • Pacemaker implant, cardiac problems, cardiac medication


  • University of California, San Francisco
    San Francisco California 94107 United States

Lead Scientist at University of California Health

  • Danielle Roubinov, PhD (ucsf)
    Assistant Professor, Psychiatry. Authored (or co-authored) 51 research publications.


in progress, not accepting new patients
Start Date
Completion Date
University of California, San Francisco
Study Type
Last Updated