Depression clinical trials at University of California Health

92 in progress, 51 open to eligible people

Showing trials for

  • Closed Loop, Doctor to Patient, Mobile Application for Depression in People With Multiple Sclerosis

    open to eligible people ages 18-80

    The researchers want to find out if an electronic application called MS CATCH can enhance patients' and doctors' experiences during and in between clinical visits. MS CATCH is a smartphone-based tool which allows patients to enter their mood related …

    at UCSF

  • Adapting and Examining Collaborative Decision Skills Training Among Veterans With Serious Mental Illness

    open to eligible people ages 18 years and up

    Recovery-oriented care is an imperative for the VA, particularly in mental health programming for Veterans with serious mental illness (SMI). Collaborative decision-making (CDM) is a recovery-oriented approach to treatment decision-making that…

    at UCSD

  • Aging and Reward System Response to Inflammation and Anxiety Study

    open to eligible people ages 60-80

    The purpose of this study is to use an experimental inflammatory challenge to examine whether older adults with symptoms of anxiety experience loss of pleasure or loss of motivation when they are exposed to inflammation. Loss of pleasure or loss of…

    at UCLA

  • Better Sleep Study

    open to eligible people ages 12-18

    The overall aim of this proposal is a confirmatory efficacy trial sufficiently powered and designed to test the hypothesis that improving the relationship between biological circadian timing and waketime, a novel modifiable target, improves…

    at UCSF

  • Biomarkers of Depression and Treatment Response

    open to eligible people ages 18-70

    This study is a stratified, parallel-group, single-center study utilizing multimodal imaging techniques to identify biomarkers for Major Depressive Disorder (MDD). The study goal is to identify biomarkers for MDD and treatment response that can be…

    at UCSF

  • Building Resilience for Surgical Recovery

    open to eligible people ages 65 years and up

    The goal of this clinical trial is to test problem solving therapy (PST) in older adults who are undergoing major surgery. The main question it aims to answer is: What is the feasibility and acceptability of delivering PST to older surgical patients …

    at UCSF

  • Cellular Aging and Neurobiology of Depression Study

    open to eligible people ages 21-60

    We are conducting an eight week longitudinal study to learn if blood levels of certain naturally occurring compounds and genetic markers differ between patients with depression and healthy adults who are not depressed, and if any such differences…

    at UCSF

  • Chronobiological Basis of Menopausal Depression: Correcting Misaligned Circadian Rhythms With Sleep and Light Interventions

    open to eligible females ages 18 years and up

    The goal of this clinical trial is to learn more about mood, sleep, and activity during menopause. The main question it aims to answer is: can mood and sleep dysfunction in menopause be improved by resetting misaligned circadian rhythm through one…

    at UCSD

  • Closed-Loop Deep Brain Stimulation for Major Depression

    open to eligible people ages 22-70

    Neurons are specialized types of cells that are responsible for carrying out the functions of the brain. Neurons communicate with electrical signals. In diseases such as major depression this electrical communication can go awry. One way to change…

    at UCSF

  • Combined Neuromodulation and Cognitive Training for Post-mTBI Depression

    open to eligible people ages 18-65

    The primary goal of this clinical trial is to evaluate whether Personalized Augmented Cognitive Training (PACT) plus intermittent theta burst stimulation (iTBS) is effective for treating depression in Service Members, Veterans, and civilians who…

    at UCSD

  • Combined Transcranial Magnetic Stimulation and Therapy for MTBI Related Headaches

    open to eligible people ages 18-65

    This study will assess the combined effectiveness of repetitive transcranial magnetic stimulation (rTMS) and telehealth based therapy in helping manage mild traumatic brain injury (mTBI) related headaches. The investigators hypothesize that active…

    at UCSD

  • Compassion Meditation vs. Health Education for Veterans

    open to eligible people ages 18 years and up

    Chronic pain (CP) is a major health problem for military Veterans, and CP is often associated with comorbid mental health problems, including posttraumatic stress disorder (PTSD) and depression. CP with psychological comorbidity is associated with…

    at UCSD

  • Cortical Inhibition As a Biomarker of Response in a Comparison of Bilateral Versus Unilateral Accelerated Theta Burst Stimulation for Suicidal Ideation in Treatment-Resistant Depression -COMBAT-SI

    open to eligible people ages 18-70

    This is a prospective clinical trial to confirm the effectiveness of bilateral accelerated theta burst stimulation (aTBS) on suicidal ideation (SI), while exploring cortical inhibition measures in this treatment paradigm. In this proposed study, the …

    at UCSD

  • Diet and Depression

    open to eligible people ages 18-80

    This study is a pilot open label crossover trial to assess the feasibility and acceptability of reducing ultra- processed foods (UPF) in a personalized manner from the diets of patients with major depressive disorder who eat a large percentage of…

    at UCSF

  • Dose-Optimized and Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression

    open to eligible people ages 18-85

    This study aims to evaluate the feasibility, safety, and tolerability of an innovative approach to treating Major Depressive Disorder (MDD), particularly in cases where patients have not responded well to traditional therapies. Specifically, the…

    at UCSD

  • COMP360 in Participants With TRD

    open to eligible people ages 18 years and up

    Efficacy, Safety, and Tolerability of a single administration of COMP360 in participants with treatment-resistant depression (TRD)

    at UCSD

  • Engaging Mothers & Babies; Reimagining Antenatal Care for Everyone (EMBRACE) Study

    open to eligible females

    This is a randomized comparative effectiveness study of two forms of enhanced prenatal care among 657 Medi-Cal eligible pregnant individuals in Fresno, California. The goal is to see whether group prenatal care with wrap around services versus…

    at UCSF

  • Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)

    open to eligible people ages 21-55

    The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. Participants will be randomly assigned to one of two…

    at UCSD

  • Evaluating tDCS Brain-stimulation in Depression Using MRI

    open to eligible people ages 20-55

    Patients, physicians, and those who fund depression research are keenly interested in depression treatments that do not involve taking medications. One promising candidate treatment is transcranial direct current stimulation (tDCS), a low-cost…

    at UCLA

  • Filipino Family Health Initiative 1.0

    open to eligible people ages 8 years and up

    The goal of this clinical trial is to test the effectiveness of an online parenting program on Filipino parents living in California. The main aims are to: - Test the effectiveness of the online Incredible Years® model of parent training and its…

    at UCSD

  • Frequency and E-field Enhancement of ITBS for Depression (FREED)

    open to eligible people ages 18-80

    The investigators propose a randomized 3-arm double-blinded parallel experimental trial (20 sessions over 4 weeks) in 75 patients with TRD. The three arms include (1) the combination of a fully Individualized form of intermittent Theta Burst…

    at UCSD

  • Health Questionnaire Study

    open to eligible people ages 18 years and up

    We want to explore if emphasizing certain instructions (i.e. "bothered by") will affect the way participants respond to a questionnaire.

    at UC Irvine

  • Healthcare Providers as Trusted Messengers to Increase Receipt of Tax Credits Among Low-income Families

    open to eligible people ages 18-99

    The purpose of this study is to pilot test the feasibility, acceptability, and preliminary efficacy of healthcare provider referrals to a tax filing app within parent-child health programs to test whether such referrals can increase receipt of tax…

    at UCLA

  • Individualized Neuromodulation for Anhedonic Depression

    open to eligible people ages 18-80

    This program of research constitutes a three-arm, randomized, placebo-controlled trial testing noninvasive brain stimulation for the treatment of anhedonic depression. This trial is part of a larger, three-site study that will be conducted at UCSD,…

    at UCSD

  • Ketamine for Veterans With Parkinson's Disease

    open to eligible people ages 40-80

    Parkinson's disease (PD) is a devastating illness that has a growing impact on Veterans. One of the most disabling symptoms is depression, which is common in PD and linked to poor quality of life and higher risk of suicide. Unfortunately, there is a …

    at UCSF

  • Maintenance rTMS for Depression (Maitr-De)

    open to eligible people ages 18-80

    Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising intervention for treatment-resistant depression (TRD), yet substantial uncertainties persist regarding its efficacy as a maintenance treatment. This prospective study…

    at UCSD

  • Meditation Accelerated Brain Stimulation for Depression

    open to eligible people ages 18 years and up

    Repetitive Transcranial magnetic stimulation (rTMS) is an FDA-approved treatment for depression that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex (DLPFC) brain region. The ultimate goal of this treatment is to…

    at UCSD

  • Meditative Neurofeedback for Depression

    open to eligible people ages 18 years and up

    The goal of this open-label single-arm study is to test a meditative neurofeedback intervention for depressed mood.

    at UCSD

  • Mindful Self-Compassion to Address PTSD and Substance Use in Unhoused Women

    open to eligible females ages 18 years and up

    Trauma exposure, posttraumatic stress disorder (PTSD), and substance use disorder (SUD) present major threats to public health. PTSD and SUD are major correlates of disability, often resulting in severe social and occupational impairment.…

    at UCLA

  • Mindfulness Engaged Neurostimulation for Depression

    open to eligible people ages 18-65

    Repetitive Transcranial Magnetic stimulation (rTMS) is an FDA-approved therapy for treatment resistant depression (TRD) that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex (DLPFC) brain region. But studies of rTMS…

    at UCSD

  • Near Infrared Spectroscopy (NIRS) for Assessment of Depression

    open to eligible people ages 18 years and up

    Develop a NIRSIT testing protocol that can be administered in the diagnostic setting and reliably distinguishes the symptoms and severity of depression, with the help of repeated measure (up to five visits per subject) comparison of patients being…

    at UCSF

  • Neural Mechanisms of Meditation Training in Healthy and Depressed Adolescents: An MRI Connectome Study PART 2

    open to eligible people ages 14-18

    The primary objective will be to study changes in putamen connectivity and depression severity in depressed teens with meditation training. H1: Putamen node strength will increase in the training group compared to the active controls. H2: This…

    at UCSF

  • Pain and Major Depressive Disorder

    open to eligible people ages 18-75

    This study will examine the effects of brain stimulation on pain symptoms associated with Major depressive disorder. This study will enroll 54 Subjects. Study subjects will be asked to complete surveys about their mood and well-being, 2 blood draws, …

    at UCLA

  • Perinatal Research on Improving Sleep and Mental Health

    open to eligible females ages 18 years and up

    The goal of this clinical trial is to compare two sleep programs in pregnant people with insomnia. The main questions it aims to answer are: 1. What is the efficacy of digital cognitive behavioral therapy for insomnia (CBT-I) versus digital sleep…

    at UCSF

  • Positive Affect Treatment for Adolescents with Early Life Adversity

    open to eligible people ages 12-16

    Youth exposed to early life adversity (ELA) are known to be at greater risk for depression and suicidality and account for almost half of the youth suffering from psychiatric diseases today. Youth exposed to ELA consistently report symptoms of…

    at UC Irvine

  • Pramipexole to Enhance Social Connections

    open to eligible people ages 18-50

    This study seeks to understand if the medication pramipexole improves social connectedness and functioning in adults (ages 18-50) who experience anxiety or depression. The study plans to enroll 108 participants total across two sites (University of…

    at UCSD

  • Primary Care-based Study of an Online Workshop for Family Caregivers of PLWD

    open to eligible people ages 18 years and up

    Many family and friend caregivers of persons living with dementia experience depression, stress, and other adverse health consequences due to the responsibilities of their caregiving role. These caregivers express a desire for education and support. …

    at UCSF

  • Probiotic Administration for Adolescent Depression

    open to eligible people ages 15-24

    This double-blind, placebo-controlled clinical trial will examine the effect of probiotic Visbiome on the brain and gut microbiome of individuals 15 to 24 years of age.

    at UCSF

  • Project 2: Optimizing Engagement and Outcomes in STAND Digital Therapy

    open to eligible people ages 18-40

    The goal is to optimize peer coaching in order to optimize engagement and outcomes in digital therapy. The unmet mental health needs of community college students are staggering and a growing body of research demonstrates that therapy provided…

    at UCLA

  • Psilocybin Therapy for Depression in Parkinson's Disease

    open to eligible people ages 40-80

    The purpose of this study is to understand whether people with Parkinson's Disease and depression have improvement in their symptoms after psilocybin therapy.

    at UCSF

  • Psilocybin-assisted CBT for Depression

    open to eligible people ages 21-60

    The primary objectives of this clinical investigation are to (1) determine the acceptability and feasibility of joining psilocybin-assisted therapy with cognitive-behavioral therapy (PA-CBT) for patients with depression, (2) optimize CBT to most…

    at UCLA

  • Resources, Inspiration, Support and Empowerment (RISE) for Black Pregnant Women

    open to eligible females ages 18-65

    Perinatal Mood and Anxiety Disorders (PMADs) encompass a range of mental health disorders that occur during pregnancy and up to one year postpartum. Approximately 13% of women experience PMADs. This rate doubles for those with adverse perinatal…

    at UCLA

  • rTMS in Alleviating Pain and Co-Morbid Symptoms in Gulf War Veterans Illness (GWVI)

    open to eligible people ages 18-65

    This study aims to look at the effectiveness of using repetitive transcranial magnetic stimulation (rTMS) in relieving pain and other co-morbid symptoms of Gulf War Illness.

    at UCSD

  • S.T.A.N.D. Alacrity Center Signature Project

    open to eligible people ages 18-40

    The purpose of this study is to evaluate clinical decision-making algorithms for (a) triaging to level of care and (b) adapting level of care in a low income, highly diverse sample of community college students at East Los Angeles College (ELAC).…

    at UCLA

  • The Reducing Risk Study

    open to eligible people ages 12-18

    The present study will test an innovative mobile health adaptation of a behavioral intervention that improves sleep and mental health concerns among adolescents.

    at UCSF

  • Treating Major Depression With Yoga Mono-therapy

    open to eligible people ages 18 years and up

    The goal of this single-center, single-blind, randomized, controlled, parallel group, interventional trial is to evaluate antidepressant efficacy of yoga monotherapy of 12-weeks duration in 180 adults meeting diagnostic criteria for mild-to-moderate …

    at UCSF

  • Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

    open to eligible people ages 22-70

    The goal of this clinical trial is to evaluate the effectiveness and safety of bilateral stimulation of the subcallosal cingulate white matter (SCCwm) using Deep Brain Stimulation (DBS) as an adjunctive treatment of non-psychotic unipolar Major…

    at UC Davis UCLA

  • Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression

    open to eligible people ages 18-65

    Depression is a leading cause of morbidity and mortality, conferring substantial healthcare and societal costs. By studying methods to non-invasively target neural circuitry involved in reward responsivity, information generated by this project will …

    at UCSF

  • Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project

    open to eligible people ages 65 years and up

    The purpose of this research study is to characterize the mechanisms contributing to cognitive impairment and accelerated cognitive decline in Late Life Depression (LLD). This is a non-randomized, observational, non-treatment study that originally…

    at UCSF

  • Inflammatory and Glutamatergic Mechanisms of Sustained Threat in Adolescents With Depression

    open to eligible people ages 14-21

    Despite the prevalence and significant public health concern over depression among adolescents, up to 40% of depressed adolescents do not respond to first-line antidepressants (herein termed treatment non-response, TNR). The goal of this project is…

    at UC Irvine UCLA UCSF

  • Reward Processing and Depressive Subtypes: Identifying Neural Biotypes

    open to eligible people ages 18-70

    Deficits in motivation and pleasure are common in depression, and thought to be caused by alterations in the ways in which the brain anticipates, evaluates, and adaptively uses reward-related information. However, reward processing is a complex,…

    at UCSF

  • Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

    Sorry, not currently recruiting here

    The purpose of this study is to examine the efficacy, safety, and tolerability of CYB003 compared to matching placebo as adjunctive treatment in participants with MDD.

    at UCSF

  • Neuroimaging Study of Open-label Placebo in Depressed Adolescents

    Sorry, in progress, not accepting new patients

    Major depressive disorder (MDD) is the current leading cause of disability worldwide and adolescence is an especially vulnerable period for the onset of depression. Non-pharmacologic approaches are particularly attractive as treatment of adolescent…

    at UCSF

  • Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

    Sorry, not currently recruiting here

    Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months …

    at UCSD

  • Pilot rTMS Trial for Knee Arthritis Pain and Depression

    Sorry, not yet accepting patients

    Osteoarthritis (OA) is a major public health problem, and involvement of the knee is especially disabling. Symptomatic knee OA has an incidence rate between 40 to 1,020 per 100,000 person years1 and is among the most common causes of disability…

    at UCLA

  • Aticaprant in Adult and Elderly Participants With Major Depressive Disorder (MDD)

    Sorry, in progress, not accepting new patients

    The purpose of this study is to assess the long-term safety and tolerability of aticaprant administered as adjunctive therapy to a current antidepressant (selective serotonin reuptake inhibitor [SSRI] or serotonin and norepinephrine reuptake…

    at UCSD

  • Oral AFA-281 in Patients with Alcohol Use Disorder

    Sorry, not yet accepting patients

    This study will evaluate the safety and exploratory efficacy of AFA-281 in patients with Alcohol use disorder on cravings, subjective response to alcohol, pain thresholds, anxiety, depression, and sleep.

    at UCLA

  • Affect Treatment for Depression and Anxiety (TAD Pilot)

    Sorry, in progress, not accepting new patients

    The goal of this study is to determine whether subjects who do not show expected clinical improvement during the early course of positive affect treatment (PAT) would benefit from switching to an alternative psychosocial treatment (negative affect…

    at UCLA

  • Amplification of Positivity for Alcohol Use Disorder Co-Occurring With Anxiety or Depression

    Sorry, currently not accepting new patients, but might later

    The purpose of this study is to examine the feasibility of a protocol in which individuals with comorbid depression or anxiety disorders and alcohol use disorder will be randomized to complete Amplification of Positivity for Alcohol Use Disorder…

    at UCSD

  • Assessing Improvements in Mood and Sleep Trial

    Sorry, not yet accepting patients

    This is a multi-site randomized control trial involving people age 55+ years who have current depression symptoms plus another suicide risk indicator (either current suicidal ideation or a past history of attempt). Our goal is evaluate which of two…

    at UCLA

  • Attachment and Biobehavioral Catch-up and Depression Treatment

    Sorry, in progress, not accepting new patients

    Maternal depression influences the development of children's behavior problems and vice versa; however most interventions singularly address maternal depression or children's behavior problems rather than both. This project assesses the efficacy of…

    at UCSF

  • Bipolar Efficacy Biomarkers for rTMS

    Sorry, in progress, not accepting new patients

    The research study is being conducted to test whether using high dose spaced theta-burst rTMS (a form of repetitive transcranial magnetic stimulation) produces a significant reduction in depressive symptoms compared with sham. This project will…

    at UCSD

  • By Youth, For Youth: Digital Supported Peer Navigation for Addressing Child Mental Health Inequities

    Sorry, not yet accepting patients

    Black and Latino youth are more likely to experience an unmet mental health or psychosocial need than do their white counterparts. Schools and primary care clinics are ideal hubs to provide mental health, healthcare, social services, and prevention…

    at UCLA UCSF

  • Can Computational Measures of Task Performance Predict Psychiatric Symptoms and Changes in Symptom Severity Across Time

    Sorry, not yet accepting patients

    This study investigates the computational mechanisms associated with psychiatric disease dimensions. The study will characterize the relationship between computational parameter estimates of task performance and psychiatric symptoms and diagnoses…

    at UCLA

  • Compressed Intermittent Theta Burst Stimulation

    Sorry, in progress, not accepting new patients

    In this proposal the investigators will use an accelerated TMS protocol that concentrates the magnetic stimulation that would usually occur over 6 weeks into 10 treatment sessions per days, for 5 consecutive days in patient with treatment-refractory …

    at UCSD

  • Black Rice Extract and Anthocyanidin Metabolites on the Synthesis and Release of BDNF in Healthy Subjects

    Sorry, in progress, not accepting new patients

    The goal of this clinical trial is to investigate the effect of black rice extract (BRE) supplementation on levels of BDNF, which is a key molecule in cognition in healthy volunteers. The main questions to answer are: Does single BRE consumption…

    at UC Davis

  • Intravenous (IV) Citalopram Hydrochloride During Transcranial Magnetic Stimulation in Major Depressive Disorder (MDD)

    Sorry, in progress, not accepting new patients

    This study will recruit 30 subjects diagnosed with Major Depressive Disorder (MDD). Subjects will be recieve one infusion treatment of citalopram or placebo and 10 treatments of a form of transcranial magnetic stimulation, theta burst stimulation…

    at UCLA

  • Electrical Vestibular Nerve Stimulation (VeNS) as a Treatment for Major Depressive Disorder (MDD)

    Sorry, not yet accepting patients

    Trial title: A Randomized, Double Blind Sham Controlled Clinical Trial to Evaluate the Efficacy of Electrical Vestibular Nerve Stimulation (VeNS), Compared to a Sham Control for Treatment of Major Depressive Disorder (MDD) - Modius Mood Study The…

    at UCSD

  • Enhancing Veteran-Clinical Collaboration in VA PRRCs

    Sorry, not yet accepting patients

    Over 60% of Veterans with serious mental illness have a service-connected disability that impairs their ability to work, go to school, and/or have successful personal lives. Although traditional treatments tend to focus on symptom remission,…

    at UCSD

  • FIT-ATOMIC Exercise Feasibility Trial

    Sorry, not yet accepting patients

    This multi-center, randomized controlled feasibility trial will assess a 20-week home-based exercise intervention in youth with Multiple Sclerosis (MS). The goal is to determine the feasibility of conducting a larger, definitive trial on exercise…

    at UCSD

  • In-patient SCC TMS

    Sorry, accepting new patients by invitation only

    The investigators are studying the feasibility, safety, and tolerability of administering accelerated repetitive Transcranial magnetic stimulation(a-rTMS) at frequencies other than standard 10 Hz for in-patient Subjects diagnosed with Major…

    at UCLA

  • Intermittent Theta Burst Stimulation for MDD

    Sorry, currently not accepting new patients, but might later

    This study will evaluate the effectiveness of intermittent Theta Burst Stimulation for patients with Major Depressive Disorder.

    at UCLA

  • Neuromodulation for Comorbid Hoarding Disorder and Depression

    Sorry, in progress, not accepting new patients

    The primary goal of this study is to evaluate whether intermittent theta burst stimulation (iTBS) is effective for treating depression in people who have depression and chronic hoarding disorder (HD). The study will also evaluate whether this…

    at UCSD

  • Parenting STAIR: Adapting a Trauma-Focused Parenting Intervention for Military-Connected Mothers and Their Children

    Sorry, not yet accepting patients

    The goal of this study is to assess Parenting STAIR Modular (PSTAIR-M), a promising and innovative intervention for military-connected mothers (MCM) who have experienced trauma and their young children (ages 2-10). PSTAIR-M aims to help mothers…

    at UC Davis

  • Personalized Brain Stimulation to Treat Chronic Concussive Symptoms

    Sorry, not yet accepting patients

    The goal of this study is to investigate a new treatment for chronic symptoms after concussion or mild traumatic brain injury in people aged 18-65 years old. Chronic symptoms could include dizziness, headache, fatigue, brain fog, memory difficulty,…

    at UCLA

  • Mirtazapine for the Dual Tx of Depression and CINV in High-Grade Glioma Pts on TMZ

    Sorry, in progress, not accepting new patients

    The purpose of the study is to estimate the ability of mirtazapine to reduce depression, nausea, and vomiting, and maintain weight in depressed glioma patients undergoing Temozolomide (TMZ) therapy. Of equal importance, the investigators will…

    at UC Irvine

  • Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV

    Sorry, not yet accepting patients

    A phase II, randomized, open-label, two-arm clinical trial evaluating the safety and efficacy of pramipexole extended release (ER) versus escitalopram for the treatment of major depressive disorder (MDD) and comorbid MDD with mild neurocognitive…

    at UCLA UCSD UCSF

  • Precision Care for Major Depressive Disorder

    Sorry, accepting new patients by invitation only

    This study aims to assess whether phenotyping-guided intervention selection is superior to intervention selection without phenotyping guidance (i.e., routine clinician and patient judgment regarding treatment selection) for depression.

    at UCSF

  • Psilocybin Therapy for Depression in Bipolar II Disorder

    Sorry, in progress, not accepting new patients

    The purpose of this study is to determine the safety, tolerability, and feasibility of psilocybin therapy in people with Bipolar II Disorder.

    at UCSF

  • Psychostimulant Augmentation of Repetitive TMS for the Treatment of Major Depressive Disorder

    Sorry, accepting new patients by invitation only

    This study analyzes the affects or Adderall extended-release (XR) in Subjects receiving brain stimulation therapy for the treatment of Major Depressive Disorder. Subjects will be assigned by chance to active or placebo group. Active group will be…

    at UCLA

  • RCT for Latina Mental Health Using Web-Based Apps

    Sorry, not yet accepting patients

    This study compares a choice-driven, interactive, evidence-informed storytelling web-based app intervention with links to resources and treatment (Tx) recommendations (made by a character via her blog) and Tx locator, to a web-based app with links…

    at UCLA

  • Repetitive Transcranial Magnetic Stimulation and Acceptance and Commitment Therapy

    Sorry, in progress, not accepting new patients

    Veterans with comorbid chronic pain and depression are highly prevalent, have poor functional status and low quality of life, are at increased risk of suicide and lack access to effective treatments. To address this problem, the proposed research…

    at UCSD

  • Resonant Frequency rTMS: A Novel Approach to Target Circuit Modulation in Major Depressive Disorder

    Sorry, accepting new patients by invitation only

    The purpose of the study is to develop a more personalized brain stimulation using repetitive transcranial magnetic stimulation or rTMS approach to treat major depressive disorder (MDD). The investigators had previously developed a personalized rTMS …

    at UCLA

  • Spatiotemporal Dynamics of the Human Emotion Network

    Sorry, accepting new patients by invitation only

    The overall goal of this study is to elucidate how emotion network dynamics relate to the behavioral, autonomic, and experiential changes that accompany emotions and to investigate how emotion network dysfunction relates to affective symptoms.…

    at UCSF

  • Spectral Correlation Coefficient-based TMS

    Sorry, accepting new patients by invitation only

    This study will analyze the feasibility, safety, and tolerability of administering repetitive Transcranial magnetic stimulation(TMS) at frequencies other than standard 10 Hz. This study will enroll 50 subjects who will undergo one quantitative…

    at UCLA

  • Supporting Peer Interactions to Expand Access to Digital Cognitive Behavioral Therapy for Spanish-speaking Patients

    Sorry, accepting new patients by invitation only

    Investigators will evaluate the implementation of an evidence-based, Spanish-language, digital, cognitive-behavioral therapy intervention (SilverCloud) in primary care settings for Latino patients with depression and/or anxiety. 426 participants…

    at UC Irvine UCSF

  • TEAMS R34 #3: Team Communication Training for Pediatric Depression Screening

    Sorry, in progress, not accepting new patients

    Pediatric depression is a global concern that has fueled efforts for enhanced detection and treatment engagement. While many health systems have implemented components of depression screening protocols, there is limited evidence of effective…

    at UCSD

  • Telepsychology in Spinal Cord Injury

    Sorry, in progress, not accepting new patients

    This study will determine the effectiveness of tele-psychology in treating persons with spinal cord injury (SCI) with depressed mood in the early period post-rehabilitation discharge. Depression among individuals with SCI is the most common…

    at UCSF

  • Role of the Microbiome in Antidepressant Treatment in Adolescents.

    Sorry, not yet accepting patients

    The goal of this observational study is to learn about the role of the human gut microbiome in antidepressant treatment response in adolescents with Major Depressive Disorder (MDD). Specifically, the study aims to collect microbiota samples of…

    at UCSD

  • Latent Structure of Multi-level Assessments and Predictors of Outcomes for Women in Recovery

    Sorry, in progress, not accepting new patients

    In this study the investigators will seek to improve their understanding of how positive and negative valence systems, cognition, and arousal/interoception are inter-related in disorders of trauma, mood, substance use, and eating behavior for women…

    at UCSD

  • Prediction of REsponse to Depression Interventions Using Clinical and TD-fNIRS Measurements

    Sorry, accepting new patients by invitation only

    The purpose of the current study is to perform a unified, homogeneous data collection protocol that includes a large cohort of patients undergoing different treatment options for Major Depressive Disorder (MDD) as an avenue for investigating optimal …

    at UCLA

  • SKY Breath Intervention

    Sorry, in progress, not accepting new patients

    Depression is highly debilitating and prevalent among adolescents. Adolescent-onset depression is associated with long, severe, and recurrent episodes that are often not responsive to treatment. There is a dire need to develop novel treatments that…

    at UCSF

Our lead scientists for Depression research studies include .

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