Summary

Eligibility
for people ages 21-65 (full criteria)
Location
at UCSD
Dates
study started
completion around
Principal Investigator
by Ruth Klaming, PhD (ucsd)

Description

Summary

Alcohol use disorder (AUD) is a major health concern amongst Veterans as it causes functional impairments and decreased quality of life. Current AUD treatments show limited effectiveness in reducing withdrawal-related psychological and physical distress, which drives the urge to drink to relieve these symptoms. The investigators propose the vagus nerve, which is the primary nerve of the "rest and digest" branch of the autonomic nervous system via its bidirectional connections between the brain and the body, as a novel treatment target for AUD. The goal of this study is to assess treatment efficacy and mechanism of action. Noninvasive neuromodulation technologies offer the possibility for innovative, low risk treatments to support the rehabilitation and community reintegration of Veterans with AUD.

Details

Keywords

Alcohol Use Disorder, neuromodulation, neuroimaging, withdrawal, anxiety, autonomic nervous system, Alcoholism, Alcohol Drinking, Cervical transcutaneous vagus nerve stimulation (active comparator)

Eligibility

Location

  • VA San Diego Healthcare System, San Diego, CA accepting new patients
    San Diego California 92161-0002 United States

Lead Scientist at University of California Health

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
VA Office of Research and Development
ID
NCT06399653
Study Type
Interventional
Participants
Expecting 80 study participants
Last Updated