Study To Evaluate Emtricitabine/Tenofovir Alafenamide (F/TAF) in Human Immunodeficiency Virus 1 (HIV-1) Infected Children and Adolescents Virologically Suppressed on a 2- Nucleoside/Nucleotide Reverse Transcriptase Inhibitor (2-NRTI)-Containing Regimen

Open to people ages 1 month to 17 years

• HIV-1 infected male and female adolescents and children aged 1 month to < 18 years at baseline/Day 1 (according to requirements of the enrolling cohort)
• Must be able to give written assent prior to any screening evaluations
• Parent or guardian able to give written informed consent prior to any screening evaluations and willing to comply with study requirements
• Body weight at screening as follows:
  • Cohort 1: ≥ 35 kg
  • Cohort 2, Group 1: ≥ 25 kg
  • Cohort 2, Group 2: 17 kg to < 25 kg
  • Cohort 3: to be updated per a protocol amendment
  • Cohort 4: to be updated per a protocol amendment
• Currently on a stable 2-NRTI containing regimen that includes a 3rd ARV agent for ≥ 6 consecutive months prior to screening
• Plasma HIV-1 RNA levels < 50 copies/mL for ≥ 6 consecutive months preceding the screening visit
• No opportunistic infection within 30 days of study entry (at baseline/Day 1)
• A negative serum β-human chorionic gonadotropin (HCG) pregnancy test is required for females of childbearing potential only

• An acquired immunodeficiency syndrome (AIDS) - indicator condition with onset within 30 days prior to screening
• Life expectancy of < 2 years
• Active, serious infections (other than HIV-1 infection) requiring parenteral antibiotic or antifungal therapy within 30 days prior to baseline/Day 1
• Evidence of active pulmonary or extra-pulmonary tuberculosis disease within 3 months of the screening visit
• Active hepatitis C virus (HCV) infection defined as positive for HCV antibody and having detectable HCV RNA
• Positive hepatitis B surface antigen or other evidence of active hepatitis B virus (HBV) infection.
• Have any serious or active medical or psychiatric illness which, in the opinion of the Investigator, would interfere with treatment, assessment, or compliance with the protocol.
• Pregnant or lactating females
• Have history of significant drug sensitivity or drug allergy
• Have previously participated in an investigational trial involving administration of any investigational agent, other than tenofovir, within 30 days prior to the study dosing

NOTE: Other protocol defined Inclusion/ Exclusion criteria may apply.